5ENB
Crystal structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in complex with o-Tolylthiourea (SGC - Diamond I04-1 fragment screening)
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue 5Q5 A 1501 |
| Chain | Residue |
| A | PRO1340 |
| A | HOH1631 |
| A | PHE1341 |
| A | VAL1345 |
| A | TYR1350 |
| A | TYR1353 |
| A | SER1392 |
| A | TYR1395 |
| A | ILE1403 |
| A | HOH1613 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1502 |
| Chain | Residue |
| A | ASP1346 |
| A | GLU1349 |
| A | SER1398 |
| A | ARG1400 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 1503 |
| Chain | Residue |
| A | GLU1326 |
| A | ARG1386 |
| A | HOH1601 |
| A | HOH1617 |
| A | HOH1623 |
| A | HOH1656 |
| A | HOH1674 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 58 |
| Details | BROMODOMAIN_1 Bromodomain signature. SepFrqpvDlleyp..DYRdiIdtpMdfatVretleagn..Yespmelckdvrl.IfsNSkaY |
| Chain | Residue | Details |
| A | SER1338-TYR1395 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 105 |
| Details | Domain: {"description":"Bromo 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
