Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004303 | molecular_function | estradiol 17-beta-dehydrogenase [NAD(P)+] activity |
A | 0005515 | molecular_function | protein binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006706 | biological_process | steroid catabolic process |
A | 0008202 | biological_process | steroid metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0042802 | molecular_function | identical protein binding |
A | 0047045 | molecular_function | testosterone 17-beta-dehydrogenase (NADP+) activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 29 |
Details | binding site for residue NAD A 301 |
Chain | Residue |
A | GLY16 |
A | ASN89 |
A | GLY91 |
A | LEU113 |
A | ILE139 |
A | SER140 |
A | SER141 |
A | TYR154 |
A | LYS158 |
A | PRO184 |
A | GLY185 |
A | ARG19 |
A | ILE187 |
A | THR189 |
A | PRO190 |
A | LEU191 |
A | TRP192 |
A | 5Q6302 |
A | HOH419 |
A | HOH426 |
A | HOH428 |
A | HOH480 |
A | GLY20 |
A | ILE21 |
A | ASP40 |
A | LYS41 |
A | CYS61 |
A | ASP62 |
A | VAL63 |
site_id | AC2 |
Number of Residues | 10 |
Details | binding site for residue 5Q6 A 302 |
Chain | Residue |
A | HIS93 |
A | SER141 |
A | GLN148 |
A | ALA149 |
A | GLN150 |
A | TYR154 |
A | ASN186 |
A | TRP192 |
A | LEU195 |
A | NAD301 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue NA A 303 |
Chain | Residue |
A | GLU50 |
A | LEU53 |
A | PRO54 |
A | ALA56 |
A | HOH413 |
Functional Information from PROSITE/UniProt
site_id | PS00061 |
Number of Residues | 29 |
Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. SlvgaigqaqAvpYVATKGAVtAMTkALA |
Chain | Residue | Details |
A | SER141-ALA169 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | TYR154 | |
site_id | SWS_FT_FI2 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | VAL13 | |
A | SER141 | |
A | LYS158 | |