5EMH
Crystal structure of Iridoid Synthase from Cantharanthus roseus in complex with NADP+
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0016099 | biological_process | monoterpenoid biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| A | 0016628 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 28 |
| Details | binding site for residue NAP A 401 |
| Chain | Residue |
| A | GLY43 |
| A | VAL92 |
| A | SER115 |
| A | TRP116 |
| A | MET128 |
| A | GLN149 |
| A | THR150 |
| A | TYR185 |
| A | PRO208 |
| A | ALA209 |
| A | VAL211 |
| A | THR45 |
| A | SER218 |
| A | MET219 |
| A | MET220 |
| A | HOH514 |
| A | HOH530 |
| A | HOH535 |
| A | HOH538 |
| A | HOH556 |
| A | HOH587 |
| A | GLY46 |
| A | ILE47 |
| A | ALA72 |
| A | ARG73 |
| A | ARG74 |
| A | CYS90 |
| A | ASP91 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000269|PubMed:26768532 |
| Chain | Residue | Details |
| A | LYS153 | |
| A | TYR185 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26551396, ECO:0000269|PubMed:26768532, ECO:0000269|PubMed:26868105, ECO:0007744|PDB:5COB, ECO:0007744|PDB:5DBF, ECO:0007744|PDB:5DF1 |
| Chain | Residue | Details |
| A | THR45 | |
| A | ARG73 | |
| A | ASP91 | |
| A | SER115 | |
| A | GLN149 | |
| A | VAL211 | |
| A | SER218 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26768532, ECO:0007744|PDB:5DBI |
| Chain | Residue | Details |
| A | LYS153 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26768532, ECO:0000269|PubMed:26868105, ECO:0007744|PDB:5COB, ECO:0007744|PDB:5DBI |
| Chain | Residue | Details |
| A | TYR185 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26768532, ECO:0000269|PubMed:26868105, ECO:0007744|PDB:5COB |
| Chain | Residue | Details |
| A | SER356 |
