5EKO
Crystal structure of MAPK13 complex with inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000165 | biological_process | MAPK cascade |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0004707 | molecular_function | MAP kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0006970 | biological_process | response to osmotic stress |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0032755 | biological_process | positive regulation of interleukin-6 production |
| A | 0033554 | biological_process | cellular response to stress |
| A | 0034644 | biological_process | cellular response to UV |
| A | 0035556 | biological_process | intracellular signal transduction |
| A | 0050729 | biological_process | positive regulation of inflammatory response |
| A | 0051403 | biological_process | stress-activated MAPK cascade |
| A | 0070301 | biological_process | cellular response to hydrogen peroxide |
| A | 0071347 | biological_process | cellular response to interleukin-1 |
| A | 0072709 | biological_process | cellular response to sorbitol |
| A | 0072740 | biological_process | cellular response to anisomycin |
| A | 0106310 | molecular_function | protein serine kinase activity |
| A | 1903936 | biological_process | cellular response to sodium arsenite |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue N17 A 401 |
| Chain | Residue |
| A | VAL39 |
| A | LEU167 |
| A | ASP168 |
| A | PHE169 |
| A | LEU171 |
| A | ALA52 |
| A | ARG68 |
| A | GLU72 |
| A | LEU76 |
| A | ILE85 |
| A | MET107 |
| A | PRO108 |
| A | MET110 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 25 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGSGAYGSVCsAidkrsgekv.........AIKK |
| Chain | Residue | Details |
| A | VAL31-LYS55 |
| site_id | PS01351 |
| Number of Residues | 103 |
| Details | MAPK MAP kinase signature. FqseifakrayREllllkhmqhenviglldvftpasslrnfydfylvmpfmqtdlqkimgmefseekiqylvyqmlkglkyihsagvvh..........RDlKpgnlavnedC |
| Chain | Residue | Details |
| A | PHE60-CYS162 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18088087","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by MAP2K3, MAP2K4, MAP2K6 and MAP2K7","evidences":[{"source":"PubMed","id":"9374491","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
