5EK6
Thermostable aldehyde dehydrogenase from Pyrobaculum sp. 1860 complexed with NADP and isobutyraldehyde
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| E | 0000166 | molecular_function | nucleotide binding |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| F | 0000166 | molecular_function | nucleotide binding |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| G | 0000166 | molecular_function | nucleotide binding |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| H | 0000166 | molecular_function | nucleotide binding |
| H | 0016491 | molecular_function | oxidoreductase activity |
| H | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 29 |
| Details | binding site for residue NAP A 500 |
| Chain | Residue |
| A | ILE151 |
| A | PRO210 |
| A | GLY211 |
| A | GLY215 |
| A | PHE229 |
| A | THR230 |
| A | GLY231 |
| A | GLU232 |
| A | THR235 |
| A | ILE239 |
| A | GLU253 |
| A | THR152 |
| A | LEU254 |
| A | GLY255 |
| A | CYS287 |
| A | GLU382 |
| A | PHE384 |
| A | PHE449 |
| A | 5OZ501 |
| A | HOH625 |
| A | HOH634 |
| A | HOH643 |
| A | PRO153 |
| A | TRP154 |
| A | ASN155 |
| A | ILE160 |
| A | LYS178 |
| A | ALA180 |
| A | SER181 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue 5OZ A 501 |
| Chain | Residue |
| A | LYS163 |
| A | THR230 |
| A | GLU253 |
| A | GLU443 |
| A | PHE449 |
| A | GLU460 |
| A | NAP500 |
| site_id | AC3 |
| Number of Residues | 27 |
| Details | binding site for residue NAP B 500 |
| Chain | Residue |
| B | ILE151 |
| B | THR152 |
| B | PRO153 |
| B | TRP154 |
| B | ASN155 |
| B | ILE160 |
| B | LYS178 |
| B | SER181 |
| B | GLY209 |
| B | PRO210 |
| B | GLY211 |
| B | GLY215 |
| B | GLU216 |
| B | PHE229 |
| B | THR230 |
| B | GLY231 |
| B | GLU232 |
| B | THR235 |
| B | GLU253 |
| B | LEU254 |
| B | GLY255 |
| B | CYS287 |
| B | GLU382 |
| B | PHE384 |
| B | PHE449 |
| B | 5OZ501 |
| B | HOH620 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue 5OZ B 501 |
| Chain | Residue |
| B | ILE160 |
| B | LYS163 |
| B | THR230 |
| B | GLU253 |
| B | GLU443 |
| B | PHE449 |
| B | GLU460 |
| B | NAP500 |
| site_id | AC5 |
| Number of Residues | 31 |
| Details | binding site for residue NAP C 500 |
| Chain | Residue |
| C | PHE449 |
| C | 5OZ501 |
| C | HOH624 |
| C | ILE151 |
| C | THR152 |
| C | PRO153 |
| C | TRP154 |
| C | ASN155 |
| C | ILE160 |
| C | LYS178 |
| C | PRO179 |
| C | ALA180 |
| C | SER181 |
| C | PRO210 |
| C | GLY211 |
| C | PRO212 |
| C | GLY215 |
| C | GLU216 |
| C | PHE229 |
| C | THR230 |
| C | GLY231 |
| C | GLU232 |
| C | THR235 |
| C | GLU238 |
| C | ILE239 |
| C | GLU253 |
| C | LEU254 |
| C | GLY255 |
| C | CYS287 |
| C | GLU382 |
| C | PHE384 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue 5OZ C 501 |
| Chain | Residue |
| C | ILE160 |
| C | LYS163 |
| C | THR230 |
| C | GLU253 |
| C | GLU443 |
| C | PHE449 |
| C | GLU460 |
| C | NAP500 |
| site_id | AC7 |
| Number of Residues | 29 |
| Details | binding site for residue NAP D 500 |
| Chain | Residue |
| D | ILE151 |
| D | THR152 |
| D | PRO153 |
| D | TRP154 |
| D | ASN155 |
| D | ILE160 |
| D | LYS178 |
| D | PRO179 |
| D | ALA180 |
| D | SER181 |
| D | GLY209 |
| D | PRO210 |
| D | GLY211 |
| D | GLY215 |
| D | GLU216 |
| D | PHE229 |
| D | THR230 |
| D | GLY231 |
| D | GLU232 |
| D | THR235 |
| D | ILE239 |
| D | GLU253 |
| D | LEU254 |
| D | GLY255 |
| D | CYS287 |
| D | GLU382 |
| D | PHE384 |
| D | PHE449 |
| D | 5OZ501 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue 5OZ D 501 |
| Chain | Residue |
| D | ILE160 |
| D | LYS163 |
| D | THR230 |
| D | GLU253 |
| D | GLU443 |
| D | PHE449 |
| D | NAP500 |
| site_id | AC9 |
| Number of Residues | 27 |
| Details | binding site for residue NAP E 500 |
| Chain | Residue |
| E | ILE151 |
| E | THR152 |
| E | PRO153 |
| E | TRP154 |
| E | ASN155 |
| E | ILE160 |
| E | LYS178 |
| E | ALA180 |
| E | SER181 |
| E | GLY209 |
| E | PRO210 |
| E | GLY211 |
| E | PRO212 |
| E | GLY215 |
| E | PHE229 |
| E | THR230 |
| E | GLY231 |
| E | GLU232 |
| E | THR235 |
| E | GLU253 |
| E | LEU254 |
| E | GLY255 |
| E | CYS287 |
| E | GLU382 |
| E | PHE384 |
| E | PHE449 |
| E | HOH627 |
| site_id | AD1 |
| Number of Residues | 27 |
| Details | binding site for residue NAP F 500 |
| Chain | Residue |
| F | ILE151 |
| F | THR152 |
| F | PRO153 |
| F | TRP154 |
| F | ASN155 |
| F | ILE160 |
| F | LYS178 |
| F | PRO179 |
| F | ALA180 |
| F | SER181 |
| F | PRO210 |
| F | GLY211 |
| F | GLY215 |
| F | PHE229 |
| F | THR230 |
| F | GLY231 |
| F | GLU232 |
| F | THR235 |
| F | ILE239 |
| F | GLU253 |
| F | LEU254 |
| F | GLY255 |
| F | CYS287 |
| F | GLU382 |
| F | PHE384 |
| F | PHE449 |
| F | HOH607 |
| site_id | AD2 |
| Number of Residues | 27 |
| Details | binding site for residue NAP G 500 |
| Chain | Residue |
| G | ILE151 |
| G | THR152 |
| G | PRO153 |
| G | TRP154 |
| G | ASN155 |
| G | ILE160 |
| G | LYS178 |
| G | ALA180 |
| G | SER181 |
| G | GLY209 |
| G | PRO210 |
| G | GLY211 |
| G | GLY215 |
| G | PHE229 |
| G | THR230 |
| G | GLY231 |
| G | GLU232 |
| G | THR235 |
| G | GLU253 |
| G | LEU254 |
| G | GLY255 |
| G | CYS287 |
| G | GLU382 |
| G | PHE384 |
| G | PHE449 |
| G | 5OZ501 |
| G | HOH622 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue 5OZ G 501 |
| Chain | Residue |
| G | ILE160 |
| G | LYS163 |
| G | THR230 |
| G | GLU253 |
| G | GLU443 |
| G | PHE449 |
| G | GLU460 |
| G | NAP500 |
| site_id | AD4 |
| Number of Residues | 30 |
| Details | binding site for residue NAP H 500 |
| Chain | Residue |
| H | ILE151 |
| H | THR152 |
| H | PRO153 |
| H | TRP154 |
| H | ASN155 |
| H | ILE160 |
| H | LYS178 |
| H | ALA180 |
| H | SER181 |
| H | GLY209 |
| H | PRO210 |
| H | GLY211 |
| H | GLY215 |
| H | GLU216 |
| H | PHE229 |
| H | THR230 |
| H | GLY231 |
| H | GLU232 |
| H | THR235 |
| H | ILE239 |
| H | GLU253 |
| H | LEU254 |
| H | GLY255 |
| H | CYS287 |
| H | GLU382 |
| H | PHE384 |
| H | PHE449 |
| H | 5OZ501 |
| H | HOH608 |
| H | HOH650 |
| site_id | AD5 |
| Number of Residues | 8 |
| Details | binding site for residue 5OZ H 501 |
| Chain | Residue |
| H | ILE160 |
| H | LYS163 |
| H | THR230 |
| H | GLU253 |
| H | GLU443 |
| H | PHE449 |
| H | GLU460 |
| H | NAP500 |
