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5EK2

Crystal structure of the indoleamine 2,3-dioxygenagse 1 (IDO1) complexed with NLG919 analogue

Functional Information from GO Data
ChainGOidnamespacecontents
A0002376biological_processimmune system process
A0002666biological_processpositive regulation of T cell tolerance induction
A0002678biological_processpositive regulation of chronic inflammatory response
A0002830biological_processpositive regulation of type 2 immune response
A0004833molecular_functiontryptophan 2,3-dioxygenase activity
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006569biological_processtryptophan catabolic process
A0006954biological_processinflammatory response
A0007565biological_processfemale pregnancy
A0009055molecular_functionelectron transfer activity
A0016491molecular_functionoxidoreductase activity
A0016702molecular_functionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
A0019441biological_processtryptophan catabolic process to kynurenine
A0020037molecular_functionheme binding
A0030485cellular_componentsmooth muscle contractile fiber
A0032421cellular_componentstereocilium bundle
A0032496biological_processresponse to lipopolysaccharide
A0032693biological_processnegative regulation of interleukin-10 production
A0032735biological_processpositive regulation of interleukin-12 production
A0033555biological_processmulticellular organismal response to stress
A0033754molecular_functionindoleamine 2,3-dioxygenase activity
A0034276biological_processkynurenic acid biosynthetic process
A0034354biological_process'de novo' NAD biosynthetic process from tryptophan
A0036269biological_processswimming behavior
A0042098biological_processT cell proliferation
A0042130biological_processnegative regulation of T cell proliferation
A0043065biological_processpositive regulation of apoptotic process
A0046006biological_processregulation of activated T cell proliferation
A0046872molecular_functionmetal ion binding
A0051213molecular_functiondioxygenase activity
A0070233biological_processnegative regulation of T cell apoptotic process
A0070234biological_processpositive regulation of T cell apoptotic process
B0002376biological_processimmune system process
B0002666biological_processpositive regulation of T cell tolerance induction
B0002678biological_processpositive regulation of chronic inflammatory response
B0002830biological_processpositive regulation of type 2 immune response
B0004833molecular_functiontryptophan 2,3-dioxygenase activity
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006569biological_processtryptophan catabolic process
B0006954biological_processinflammatory response
B0007565biological_processfemale pregnancy
B0009055molecular_functionelectron transfer activity
B0016491molecular_functionoxidoreductase activity
B0016702molecular_functionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
B0019441biological_processtryptophan catabolic process to kynurenine
B0020037molecular_functionheme binding
B0030485cellular_componentsmooth muscle contractile fiber
B0032421cellular_componentstereocilium bundle
B0032496biological_processresponse to lipopolysaccharide
B0032693biological_processnegative regulation of interleukin-10 production
B0032735biological_processpositive regulation of interleukin-12 production
B0033555biological_processmulticellular organismal response to stress
B0033754molecular_functionindoleamine 2,3-dioxygenase activity
B0034276biological_processkynurenic acid biosynthetic process
B0034354biological_process'de novo' NAD biosynthetic process from tryptophan
B0036269biological_processswimming behavior
B0042098biological_processT cell proliferation
B0042130biological_processnegative regulation of T cell proliferation
B0043065biological_processpositive regulation of apoptotic process
B0046006biological_processregulation of activated T cell proliferation
B0046872molecular_functionmetal ion binding
B0051213molecular_functiondioxygenase activity
B0070233biological_processnegative regulation of T cell apoptotic process
B0070234biological_processpositive regulation of T cell apoptotic process
Functional Information from PDB Data
site_idAC1
Number of Residues18
Detailsbinding site for residue HEM A 501
ChainResidue
APHE163
APHE291
AARG343
AHIS346
AILE349
AVAL350
ALEU388
AVAL391
A5PJ502
AHOH621
ASER167
AVAL170
APHE214
AILE217
APHE226
ASER263
AALA264
APHE270

site_idAC2
Number of Residues7
Detailsbinding site for residue 5PJ A 502
ChainResidue
ACYS129
AVAL130
APHE163
AGLY262
ASER263
AALA264
AHEM501

site_idAC3
Number of Residues18
Detailsbinding site for residue HEM B 501
ChainResidue
BPHE163
BSER167
BVAL170
BPHE214
BPHE226
BSER263
BALA264
BPHE270
BPHE291
BARG343
BHIS346
BILE349
BVAL350
BTYR353
BILE354
BVAL391
B5PJ502
BHOH603

site_idAC4
Number of Residues9
Detailsbinding site for residue 5PJ B 502
ChainResidue
BCYS129
BVAL130
BPHE163
BSER167
BLEU234
BGLY262
BSER263
BALA264
BHEM501

Functional Information from PROSITE/UniProt
site_idPS00876
Number of Residues11
DetailsIDO_1 Indoleamine 2,3-dioxygenase signature 1. GGSAGQSSvfQ
ChainResidueDetails
AGLY261-GLN271

site_idPS00877
Number of Residues14
DetailsIDO_2 Indoleamine 2,3-dioxygenase signature 2. FLQDMrrYMppaHR
ChainResidueDetails
APHE291-ARG304

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: proximal binding residue => ECO:0000269|PubMed:16477023, ECO:0000269|PubMed:25313323, ECO:0007744|PDB:2D0T, ECO:0007744|PDB:2D0U, ECO:0007744|PDB:4PK5, ECO:0007744|PDB:4PK6
ChainResidueDetails
AHIS346
BHIS346

218853

PDB entries from 2024-04-24

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