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5EK2

Crystal structure of the indoleamine 2,3-dioxygenagse 1 (IDO1) complexed with NLG919 analogue

Functional Information from GO Data
ChainGOidnamespacecontents
A0002376biological_processimmune system process
A0004833molecular_functionL-tryptophan 2,3-dioxygenase activity
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006569biological_processL-tryptophan catabolic process
A0007565biological_processfemale pregnancy
A0009055molecular_functionelectron transfer activity
A0016491molecular_functionoxidoreductase activity
A0019441biological_processL-tryptophan catabolic process to kynurenine
A0019805biological_processquinolinate biosynthetic process
A0020037molecular_functionheme binding
A0030485cellular_componentsmooth muscle contractile fiber
A0032421cellular_componentstereocilium bundle
A0033754molecular_functionindoleamine 2,3-dioxygenase activity
A0034354biological_process'de novo' NAD+ biosynthetic process from L-tryptophan
A0046006biological_processregulation of activated T cell proliferation
A0046872molecular_functionmetal ion binding
A0051213molecular_functiondioxygenase activity
A0070234biological_processpositive regulation of T cell apoptotic process
B0002376biological_processimmune system process
B0004833molecular_functionL-tryptophan 2,3-dioxygenase activity
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006569biological_processL-tryptophan catabolic process
B0007565biological_processfemale pregnancy
B0009055molecular_functionelectron transfer activity
B0016491molecular_functionoxidoreductase activity
B0019441biological_processL-tryptophan catabolic process to kynurenine
B0019805biological_processquinolinate biosynthetic process
B0020037molecular_functionheme binding
B0030485cellular_componentsmooth muscle contractile fiber
B0032421cellular_componentstereocilium bundle
B0033754molecular_functionindoleamine 2,3-dioxygenase activity
B0034354biological_process'de novo' NAD+ biosynthetic process from L-tryptophan
B0046006biological_processregulation of activated T cell proliferation
B0046872molecular_functionmetal ion binding
B0051213molecular_functiondioxygenase activity
B0070234biological_processpositive regulation of T cell apoptotic process
Functional Information from PDB Data
site_idAC1
Number of Residues18
Detailsbinding site for residue HEM A 501
ChainResidue
APHE163
APHE291
AARG343
AHIS346
AILE349
AVAL350
ALEU388
AVAL391
A5PJ502
AHOH621
ASER167
AVAL170
APHE214
AILE217
APHE226
ASER263
AALA264
APHE270

site_idAC2
Number of Residues7
Detailsbinding site for residue 5PJ A 502
ChainResidue
ACYS129
AVAL130
APHE163
AGLY262
ASER263
AALA264
AHEM501

site_idAC3
Number of Residues18
Detailsbinding site for residue HEM B 501
ChainResidue
BPHE163
BSER167
BVAL170
BPHE214
BPHE226
BSER263
BALA264
BPHE270
BPHE291
BARG343
BHIS346
BILE349
BVAL350
BTYR353
BILE354
BVAL391
B5PJ502
BHOH603

site_idAC4
Number of Residues9
Detailsbinding site for residue 5PJ B 502
ChainResidue
BCYS129
BVAL130
BPHE163
BSER167
BLEU234
BGLY262
BSER263
BALA264
BHEM501

Functional Information from PROSITE/UniProt
site_idPS00876
Number of Residues11
DetailsIDO_1 Indoleamine 2,3-dioxygenase signature 1. GGSAGQSSvfQ
ChainResidueDetails
AGLY261-GLN271

site_idPS00877
Number of Residues14
DetailsIDO_2 Indoleamine 2,3-dioxygenase signature 2. FLQDMrrYMppaHR
ChainResidueDetails
APHE291-ARG304

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBinding site: {"description":"proximal binding residue","evidences":[{"source":"PubMed","id":"16477023","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25313323","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2D0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2D0U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PK6","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246031

PDB entries from 2025-12-10

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