5EJ4
EcMenD-ThDP-Mn2+ complex soaked with 2-ketoglutarate for 15 min
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0009234 | biological_process | menaquinone biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0030976 | molecular_function | thiamine pyrophosphate binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0009234 | biological_process | menaquinone biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0030976 | molecular_function | thiamine pyrophosphate binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0009234 | biological_process | menaquinone biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0030145 | molecular_function | manganese ion binding |
| C | 0030976 | molecular_function | thiamine pyrophosphate binding |
| C | 0042803 | molecular_function | protein homodimerization activity |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0009234 | biological_process | menaquinone biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0030145 | molecular_function | manganese ion binding |
| D | 0030976 | molecular_function | thiamine pyrophosphate binding |
| D | 0042803 | molecular_function | protein homodimerization activity |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
| E | 0000287 | molecular_function | magnesium ion binding |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0009234 | biological_process | menaquinone biosynthetic process |
| E | 0016740 | molecular_function | transferase activity |
| E | 0030145 | molecular_function | manganese ion binding |
| E | 0030976 | molecular_function | thiamine pyrophosphate binding |
| E | 0042803 | molecular_function | protein homodimerization activity |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
| F | 0000287 | molecular_function | magnesium ion binding |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0009234 | biological_process | menaquinone biosynthetic process |
| F | 0016740 | molecular_function | transferase activity |
| F | 0030145 | molecular_function | manganese ion binding |
| F | 0030976 | molecular_function | thiamine pyrophosphate binding |
| F | 0042803 | molecular_function | protein homodimerization activity |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
| G | 0000287 | molecular_function | magnesium ion binding |
| G | 0003824 | molecular_function | catalytic activity |
| G | 0009234 | biological_process | menaquinone biosynthetic process |
| G | 0016740 | molecular_function | transferase activity |
| G | 0030145 | molecular_function | manganese ion binding |
| G | 0030976 | molecular_function | thiamine pyrophosphate binding |
| G | 0042803 | molecular_function | protein homodimerization activity |
| G | 0046872 | molecular_function | metal ion binding |
| G | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
| H | 0000287 | molecular_function | magnesium ion binding |
| H | 0003824 | molecular_function | catalytic activity |
| H | 0009234 | biological_process | menaquinone biosynthetic process |
| H | 0016740 | molecular_function | transferase activity |
| H | 0030145 | molecular_function | manganese ion binding |
| H | 0030976 | molecular_function | thiamine pyrophosphate binding |
| H | 0042803 | molecular_function | protein homodimerization activity |
| H | 0046872 | molecular_function | metal ion binding |
| H | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 30 |
| Details | binding site for residue TD6 A 601 |
| Chain | Residue |
| A | ASN390 |
| A | GLY441 |
| A | ASP442 |
| A | LEU443 |
| A | SER444 |
| A | TYR447 |
| A | ASN469 |
| A | GLY471 |
| A | GLY472 |
| A | GLN473 |
| A | ILE474 |
| A | SER391 |
| A | MN602 |
| A | HOH854 |
| A | HOH877 |
| A | HOH988 |
| B | PRO30 |
| B | GLU55 |
| B | THR81 |
| B | ALA82 |
| B | ASN117 |
| B | GLN118 |
| A | LEU392 |
| B | FMT601 |
| A | ARG395 |
| A | ARG413 |
| A | SER416 |
| A | GLY417 |
| A | ILE418 |
| A | ASP419 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MN A 602 |
| Chain | Residue |
| A | ASP442 |
| A | ASN469 |
| A | GLY471 |
| A | TD6601 |
| A | HOH877 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 603 |
| Chain | Residue |
| A | HIS49 |
| A | HIS50 |
| A | THR51 |
| A | ARG430 |
| A | LEU454 |
| A | GLN457 |
| A | HOH801 |
| A | HOH807 |
| A | HOH939 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 604 |
| Chain | Residue |
| A | ARG364 |
| A | HIS374 |
| A | ARG375 |
| A | CYS377 |
| A | ASP378 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue FMT A 605 |
| Chain | Residue |
| A | GLY31 |
| A | SER32 |
| A | ARG33 |
| A | THR78 |
| A | ARG107 |
| A | GLN118 |
| A | HOH874 |
| B | TD6602 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue FMT B 601 |
| Chain | Residue |
| A | TD6601 |
| B | GLY31 |
| B | SER32 |
| B | ARG33 |
| B | THR78 |
| B | ARG107 |
| B | GLN118 |
| B | HOH710 |
| site_id | AC7 |
| Number of Residues | 30 |
| Details | binding site for residue TD6 B 602 |
| Chain | Residue |
| A | PRO30 |
| A | GLU55 |
| A | THR81 |
| A | ALA82 |
| A | ASN117 |
| A | GLN118 |
| A | FMT605 |
| B | ASN390 |
| B | SER391 |
| B | LEU392 |
| B | ARG395 |
| B | ARG413 |
| B | SER416 |
| B | GLY417 |
| B | ILE418 |
| B | ASP419 |
| B | GLY441 |
| B | ASP442 |
| B | LEU443 |
| B | SER444 |
| B | TYR447 |
| B | ASN469 |
| B | GLY471 |
| B | GLY472 |
| B | GLN473 |
| B | ILE474 |
| B | MN603 |
| B | HOH748 |
| B | HOH803 |
| B | HOH946 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue MN B 603 |
| Chain | Residue |
| B | HOH748 |
| B | ASP442 |
| B | ASN469 |
| B | GLY471 |
| B | TD6602 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 604 |
| Chain | Residue |
| B | HIS49 |
| B | HIS50 |
| B | THR51 |
| B | ARG430 |
| B | LEU454 |
| B | GLN457 |
| B | HOH772 |
| B | HOH861 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 605 |
| Chain | Residue |
| A | HOH701 |
| B | ILE361 |
| B | ARG364 |
| B | HIS374 |
| B | ASP378 |
| B | HOH1004 |
| site_id | AD2 |
| Number of Residues | 29 |
| Details | binding site for residue TD6 C 601 |
| Chain | Residue |
| C | ASN390 |
| C | SER391 |
| C | LEU392 |
| C | ARG395 |
| C | ARG413 |
| C | SER416 |
| C | GLY417 |
| C | ILE418 |
| C | ASP419 |
| C | GLY441 |
| C | ASP442 |
| C | LEU443 |
| C | SER444 |
| C | TYR447 |
| C | ASN469 |
| C | GLY471 |
| C | GLY472 |
| C | GLN473 |
| C | ILE474 |
| C | MN602 |
| C | HOH783 |
| C | HOH864 |
| C | HOH991 |
| D | PRO30 |
| D | GLU55 |
| D | THR81 |
| D | ASN117 |
| D | GLN118 |
| D | FMT601 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue MN C 602 |
| Chain | Residue |
| C | ASP442 |
| C | ASN469 |
| C | GLY471 |
| C | TD6601 |
| C | HOH783 |
| site_id | AD4 |
| Number of Residues | 9 |
| Details | binding site for residue GOL C 603 |
| Chain | Residue |
| C | HIS49 |
| C | HIS50 |
| C | THR51 |
| C | ARG430 |
| C | LEU454 |
| C | GLN457 |
| C | HOH769 |
| C | HOH922 |
| C | HOH926 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 604 |
| Chain | Residue |
| C | ARG364 |
| C | HIS374 |
| C | ARG375 |
| C | ASP378 |
| C | HOH867 |
| site_id | AD6 |
| Number of Residues | 7 |
| Details | binding site for residue FMT C 605 |
| Chain | Residue |
| C | SER32 |
| C | ARG33 |
| C | THR78 |
| C | ARG107 |
| C | GLN118 |
| C | HOH880 |
| D | TD6602 |
| site_id | AD7 |
| Number of Residues | 7 |
| Details | binding site for residue FMT D 601 |
| Chain | Residue |
| C | TD6601 |
| D | SER32 |
| D | ARG33 |
| D | THR78 |
| D | ARG107 |
| D | GLN118 |
| D | HOH974 |
| site_id | AD8 |
| Number of Residues | 30 |
| Details | binding site for residue TD6 D 602 |
| Chain | Residue |
| C | PRO30 |
| C | GLU55 |
| C | THR81 |
| C | ALA82 |
| C | ASN117 |
| C | GLN118 |
| C | FMT605 |
| D | ASN390 |
| D | SER391 |
| D | LEU392 |
| D | ARG395 |
| D | ARG413 |
| D | SER416 |
| D | GLY417 |
| D | ILE418 |
| D | ASP419 |
| D | GLY441 |
| D | ASP442 |
| D | LEU443 |
| D | SER444 |
| D | TYR447 |
| D | ASN469 |
| D | GLY471 |
| D | GLY472 |
| D | GLN473 |
| D | ILE474 |
| D | MN603 |
| D | HOH866 |
| D | HOH875 |
| D | HOH988 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue MN D 603 |
| Chain | Residue |
| D | ASP442 |
| D | ASN469 |
| D | GLY471 |
| D | TD6602 |
| D | HOH866 |
| site_id | AE1 |
| Number of Residues | 8 |
| Details | binding site for residue GOL D 604 |
| Chain | Residue |
| D | HIS49 |
| D | HIS50 |
| D | THR51 |
| D | ARG430 |
| D | LEU454 |
| D | GLN457 |
| D | HOH722 |
| D | HOH908 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL D 605 |
| Chain | Residue |
| D | ARG364 |
| D | HIS374 |
| D | CYS377 |
| D | ASP378 |
| D | HOH718 |
| site_id | AE3 |
| Number of Residues | 30 |
| Details | binding site for residue TD6 E 601 |
| Chain | Residue |
| E | ASN390 |
| E | SER391 |
| E | LEU392 |
| E | ARG395 |
| E | ARG413 |
| E | SER416 |
| E | GLY417 |
| E | ILE418 |
| E | ASP419 |
| E | GLY441 |
| E | ASP442 |
| E | LEU443 |
| E | SER444 |
| E | TYR447 |
| E | ASN469 |
| E | GLY471 |
| E | GLY472 |
| E | GLN473 |
| E | ILE474 |
| E | MN602 |
| E | HOH827 |
| E | HOH919 |
| E | HOH933 |
| F | PRO30 |
| F | GLU55 |
| F | THR81 |
| F | ALA82 |
| F | ASN117 |
| F | GLN118 |
| F | FMT601 |
| site_id | AE4 |
| Number of Residues | 5 |
| Details | binding site for residue MN E 602 |
| Chain | Residue |
| E | ASP442 |
| E | ASN469 |
| E | GLY471 |
| E | TD6601 |
| E | HOH827 |
| site_id | AE5 |
| Number of Residues | 9 |
| Details | binding site for residue GOL E 603 |
| Chain | Residue |
| E | HIS49 |
| E | HIS50 |
| E | THR51 |
| E | ARG430 |
| E | LEU454 |
| E | GLN457 |
| E | HOH723 |
| E | HOH805 |
| E | HOH873 |
| site_id | AE6 |
| Number of Residues | 4 |
| Details | binding site for residue GOL E 604 |
| Chain | Residue |
| E | ARG364 |
| E | HIS374 |
| E | ASP378 |
| E | HOH1035 |
| site_id | AE7 |
| Number of Residues | 9 |
| Details | binding site for residue FMT E 605 |
| Chain | Residue |
| E | GLY31 |
| E | SER32 |
| E | ARG33 |
| E | THR78 |
| E | ARG107 |
| E | GLN118 |
| E | HOH817 |
| E | HOH937 |
| F | TD6602 |
| site_id | AE8 |
| Number of Residues | 8 |
| Details | binding site for residue FMT F 601 |
| Chain | Residue |
| E | TD6601 |
| F | SER32 |
| F | ARG33 |
| F | THR78 |
| F | ARG107 |
| F | GLN118 |
| F | HOH832 |
| F | HOH863 |
| site_id | AE9 |
| Number of Residues | 30 |
| Details | binding site for residue TD6 F 602 |
| Chain | Residue |
| E | PRO30 |
| E | GLU55 |
| E | THR81 |
| E | ALA82 |
| E | ASN117 |
| E | GLN118 |
| E | FMT605 |
| F | ASN390 |
| F | SER391 |
| F | LEU392 |
| F | ARG395 |
| F | ARG413 |
| F | SER416 |
| F | GLY417 |
| F | ILE418 |
| F | ASP419 |
| F | GLY441 |
| F | ASP442 |
| F | LEU443 |
| F | SER444 |
| F | TYR447 |
| F | ASN469 |
| F | GLY471 |
| F | GLY472 |
| F | GLN473 |
| F | ILE474 |
| F | MN603 |
| F | HOH779 |
| F | HOH791 |
| F | HOH966 |
| site_id | AF1 |
| Number of Residues | 5 |
| Details | binding site for residue MN F 603 |
| Chain | Residue |
| F | ASP442 |
| F | ASN469 |
| F | GLY471 |
| F | TD6602 |
| F | HOH791 |
| site_id | AF2 |
| Number of Residues | 9 |
| Details | binding site for residue GOL F 604 |
| Chain | Residue |
| F | HIS49 |
| F | HIS50 |
| F | THR51 |
| F | ARG430 |
| F | LEU454 |
| F | GLN457 |
| F | HOH834 |
| F | HOH848 |
| F | HOH976 |
| site_id | AF3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL F 605 |
| Chain | Residue |
| F | ARG364 |
| F | HIS374 |
| F | ARG375 |
| F | CYS377 |
| F | ASP378 |
| site_id | AF4 |
| Number of Residues | 31 |
| Details | binding site for residue TD6 G 601 |
| Chain | Residue |
| G | ASN390 |
| G | SER391 |
| G | LEU392 |
| G | ARG395 |
| G | ARG413 |
| G | SER416 |
| G | GLY417 |
| G | ILE418 |
| G | ASP419 |
| G | GLY441 |
| G | ASP442 |
| G | LEU443 |
| G | SER444 |
| G | TYR447 |
| G | ASN469 |
| G | GLY471 |
| G | GLY472 |
| G | GLN473 |
| G | ILE474 |
| G | MN602 |
| G | HOH801 |
| G | HOH919 |
| G | HOH1029 |
| G | HOH1031 |
| H | PRO30 |
| H | GLU55 |
| H | THR81 |
| H | ALA82 |
| H | ASN117 |
| H | GLN118 |
| H | FMT601 |
| site_id | AF5 |
| Number of Residues | 5 |
| Details | binding site for residue MN G 602 |
| Chain | Residue |
| G | ASP442 |
| G | ASN469 |
| G | GLY471 |
| G | TD6601 |
| G | HOH919 |
| site_id | AF6 |
| Number of Residues | 9 |
| Details | binding site for residue GOL G 603 |
| Chain | Residue |
| G | HIS49 |
| G | HIS50 |
| G | THR51 |
| G | ARG430 |
| G | LEU454 |
| G | GLN457 |
| G | HOH734 |
| G | HOH811 |
| G | HOH912 |
| site_id | AF7 |
| Number of Residues | 4 |
| Details | binding site for residue GOL G 604 |
| Chain | Residue |
| G | ARG364 |
| G | HIS374 |
| G | ARG375 |
| G | ASP378 |
| site_id | AF8 |
| Number of Residues | 9 |
| Details | binding site for residue FMT G 605 |
| Chain | Residue |
| G | GLY31 |
| G | SER32 |
| G | ARG33 |
| G | THR78 |
| G | ARG107 |
| G | GLN118 |
| G | HOH755 |
| G | HOH988 |
| H | TD6602 |
| site_id | AF9 |
| Number of Residues | 9 |
| Details | binding site for residue FMT H 601 |
| Chain | Residue |
| G | TD6601 |
| G | HOH1029 |
| H | GLY31 |
| H | SER32 |
| H | ARG33 |
| H | THR78 |
| H | ARG107 |
| H | GLN118 |
| H | HOH891 |
| site_id | AG1 |
| Number of Residues | 30 |
| Details | binding site for residue TD6 H 602 |
| Chain | Residue |
| G | PRO30 |
| G | GLU55 |
| G | THR81 |
| G | ALA82 |
| G | ASN117 |
| G | GLN118 |
| G | FMT605 |
| H | ASN390 |
| H | SER391 |
| H | LEU392 |
| H | ARG395 |
| H | ARG413 |
| H | SER416 |
| H | GLY417 |
| H | ILE418 |
| H | ASP419 |
| H | GLY441 |
| H | ASP442 |
| H | LEU443 |
| H | SER444 |
| H | TYR447 |
| H | ASN469 |
| H | GLY471 |
| H | GLY472 |
| H | GLN473 |
| H | ILE474 |
| H | MN603 |
| H | HOH816 |
| H | HOH884 |
| H | HOH955 |
| site_id | AG2 |
| Number of Residues | 5 |
| Details | binding site for residue MN H 603 |
| Chain | Residue |
| H | ASP442 |
| H | ASN469 |
| H | GLY471 |
| H | TD6602 |
| H | HOH816 |
| site_id | AG3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL H 604 |
| Chain | Residue |
| G | HOH928 |
| H | HIS50 |
| H | THR51 |
| H | ARG430 |
| H | LEU454 |
| H | HOH741 |
| H | HOH754 |
| site_id | AG4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL H 605 |
| Chain | Residue |
| G | HOH1092 |
| H | ARG364 |
| H | HIS374 |
| H | ASP378 |
| H | HOH807 |
