5EI4

First domain of human bromodomain BRD4 in complex with inhibitor 8-(5-Amino-1H-[1,2,4]triazol-3-ylsulfanylmethyl)-3-(4-chlorobenzyl)-7-ethyl-3,7-dihydropurine-2,6-dione

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue EDO A 201

Chain	Residue
A	ILE100
A	ILE101
A	LYS102
A	THR103
A	ASN135

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site_id	AC2
Number of Residues	17
Details	binding site for residue 5NV A 202

Chain	Residue
A	PRO86
A	VAL87
A	ASP88
A	LEU92
A	LYS99
A	ASN140
A	MET149
A	HOH301
A	HOH302
A	HOH303
A	HOH316
A	HOH336
A	HOH386
A	TRP81
A	PRO82
A	PHE83
A	GLN85

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Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY

Chain	Residue	Details
A	ALA80-TYR139

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Acetylated histone binding => ECO:0000269|PubMed:22464331

Chain	Residue	Details
A	ASN140

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site_id	SWS_FT_FI2
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS99

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