5EI0

Structure of RCL-cleaved vaspin (serpinA12)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004867	molecular_function	serine-type endopeptidase inhibitor activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005886	cellular_component	plasma membrane
A	0006094	biological_process	gluconeogenesis
A	0008610	biological_process	lipid biosynthetic process
A	0010466	biological_process	negative regulation of peptidase activity
A	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0045721	biological_process	negative regulation of gluconeogenesis
A	0046628	biological_process	positive regulation of insulin receptor signaling pathway
A	0051055	biological_process	negative regulation of lipid biosynthetic process
A	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0090181	biological_process	regulation of cholesterol metabolic process
A	0090207	biological_process	regulation of triglyceride metabolic process
A	0140678	molecular_function	molecular function inhibitor activity
E	0004867	molecular_function	serine-type endopeptidase inhibitor activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005886	cellular_component	plasma membrane
E	0006094	biological_process	gluconeogenesis
E	0008610	biological_process	lipid biosynthetic process
E	0010466	biological_process	negative regulation of peptidase activity
E	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
E	0045721	biological_process	negative regulation of gluconeogenesis
E	0046628	biological_process	positive regulation of insulin receptor signaling pathway
E	0051055	biological_process	negative regulation of lipid biosynthetic process
E	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
E	0090181	biological_process	regulation of cholesterol metabolic process
E	0090207	biological_process	regulation of triglyceride metabolic process
E	0140678	molecular_function	molecular function inhibitor activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	SITE: Cleavage => ECO:0000269|PubMed:26529565

Chain	Residue	Details
A	MET378
E	MET378

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site_id	SWS_FT_FI2
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:28668641

Chain	Residue	Details
A	ASN221
A	ASN233
E	ASN221
E	ASN233

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine => ECO:0000269|PubMed:28668641

Chain	Residue	Details
A	ASN267
E	ASN267

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