Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 501 |
| Chain | Residue |
| A | TRP268 |
| A | ARG426 |
| A | PHE427 |
| A | ASP428 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 502 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue EDO A 503 |
| Chain | Residue |
| A | PRO157 |
| A | ARG159 |
| A | GLN176 |
| A | HOH612 |
| A | HOH639 |
| A | PHE68 |
| A | LEU149 |
| A | SER155 |
| A | LEU156 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 504 |
| Chain | Residue |
| A | LEU149 |
| A | ASN150 |
| A | VAL151 |
| A | LEU152 |
| A | HOH619 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 505 |
| Chain | Residue |
| A | ARG95 |
| A | THR206 |
| A | ASP208 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 506 |
| Chain | Residue |
| A | LEU278 |
| A | MSE284 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 507 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue C8E A 508 |
| Chain | Residue |
| A | VAL244 |
| A | PRO245 |
| A | SER386 |
| A | VAL454 |
| A | GLN459 |
| D | PRO245 |
| D | PHE246 |
| D | HIS299 |
| D | C8E511 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 501 |
| Chain | Residue |
| B | HIS69 |
| B | PHE427 |
| B | HOH725 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 502 |
| Chain | Residue |
| B | PHE246 |
| B | C8E512 |
| B | HOH696 |
| C | C8E509 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 503 |
| Chain | Residue |
| B | GLN57 |
| B | VAL61 |
| B | HOH673 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 504 |
| Chain | Residue |
| B | TRP268 |
| B | ALA425 |
| B | ARG426 |
| B | PHE427 |
| B | ASP428 |
| site_id | AD4 |
| Number of Residues | 10 |
| Details | binding site for residue EDO B 505 |
| Chain | Residue |
| B | THR56 |
| B | GLN57 |
| B | ALA58 |
| B | THR328 |
| B | LEU329 |
| B | ASN330 |
| B | GLU368 |
| B | HOH606 |
| B | HOH608 |
| B | HOH631 |
| site_id | AD5 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 506 |
| Chain | Residue |
| B | LEU267 |
| B | TRP268 |
| B | THR269 |
| B | VAL448 |
| B | ALA450 |
| B | LEU455 |
| B | ALA460 |
| site_id | AD6 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 507 |
| Chain | Residue |
| B | ASP142 |
| B | HOH693 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 508 |
| Chain | Residue |
| B | MSE242 |
| B | VAL306 |
| B | PHE307 |
| B | SER386 |
| B | LEU387 |
| site_id | AD8 |
| Number of Residues | 1 |
| Details | binding site for residue EDO B 509 |
| site_id | AD9 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 511 |
| Chain | Residue |
| B | MSE242 |
| B | TRP379 |
| site_id | AE1 |
| Number of Residues | 9 |
| Details | binding site for residue C8E B 512 |
| Chain | Residue |
| B | VAL244 |
| B | PRO245 |
| B | PHE246 |
| B | VAL454 |
| B | LEU455 |
| B | EDO502 |
| C | HIS299 |
| C | EDO501 |
| C | C8E509 |
| site_id | AE2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 501 |
| Chain | Residue |
| B | C8E512 |
| C | PRO245 |
| C | PHE246 |
| C | C8E509 |
| site_id | AE3 |
| Number of Residues | 9 |
| Details | binding site for residue EDO C 502 |
| Chain | Residue |
| C | MSE242 |
| C | ALA243 |
| C | VAL306 |
| C | PHE307 |
| C | GLY308 |
| C | LEU385 |
| C | SER386 |
| C | LEU387 |
| C | HOH622 |
| site_id | AE4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO C 503 |
| Chain | Residue |
| C | SER97 |
| C | ILE98 |
| C | THR101 |
| C | GLN112 |
| C | ASP208 |
| C | PHE209 |
| C | ALA210 |
| site_id | AE5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 504 |
| Chain | Residue |
| C | VAL61 |
| C | PHE331 |
| C | LEU369 |
| C | HOH620 |
| site_id | AE6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO C 505 |
| Chain | Residue |
| B | SER302 |
| B | ARG303 |
| C | GLY301 |
| C | SER302 |
| C | ARG303 |
| site_id | AE7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 506 |
| Chain | Residue |
| C | ASP142 |
| C | TRP146 |
| C | PRO147 |
| site_id | AE8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 507 |
| Chain | Residue |
| C | TRP268 |
| C | ARG426 |
| C | PHE427 |
| C | ASP428 |
| site_id | AE9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 508 |
| Chain | Residue |
| C | LEU329 |
| C | ASN393 |
| C | ILE394 |
| site_id | AF1 |
| Number of Residues | 9 |
| Details | binding site for residue C8E C 509 |
| Chain | Residue |
| B | HIS299 |
| B | EDO502 |
| B | C8E512 |
| C | VAL244 |
| C | PRO245 |
| C | SER386 |
| C | VAL454 |
| C | LEU455 |
| C | EDO501 |
| site_id | AF2 |
| Number of Residues | 1 |
| Details | binding site for residue EDO D 501 |
| site_id | AF3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO D 502 |
| Chain | Residue |
| D | MSE242 |
| D | ALA243 |
| D | VAL306 |
| D | PHE307 |
| D | SER386 |
| site_id | AF4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO D 503 |
| Chain | Residue |
| D | TRP141 |
| D | PHE424 |
| D | ALA425 |
| D | ARG426 |
| D | HOH618 |
| site_id | AF5 |
| Number of Residues | 2 |
| Details | binding site for residue EDO D 504 |
| Chain | Residue |
| D | ALA425 |
| D | PHE427 |
| site_id | AF6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 505 |
| Chain | Residue |
| D | GLN226 |
| D | GLN231 |
| D | GLN231 |
| D | HIS235 |
| site_id | AF7 |
| Number of Residues | 2 |
| Details | binding site for residue EDO D 506 |
| Chain | Residue |
| D | GLU382 |
| D | THR383 |
| site_id | AF8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO D 507 |
| Chain | Residue |
| D | TRP268 |
| D | ALA425 |
| D | ARG426 |
| D | PHE427 |
| D | ASP428 |
| site_id | AF9 |
| Number of Residues | 1 |
| Details | binding site for residue EDO D 508 |
| site_id | AG1 |
| Number of Residues | 1 |
| Details | binding site for residue EDO D 509 |
| site_id | AG2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 510 |
| Chain | Residue |
| D | LEU329 |
| D | GLN390 |
| D | GLN392 |
| site_id | AG3 |
| Number of Residues | 9 |
| Details | binding site for residue C8E D 511 |
| Chain | Residue |
| A | PHE246 |
| A | HIS299 |
| A | C8E508 |
| D | VAL244 |
| D | PRO245 |
| D | LEU300 |
| D | SER386 |
| D | VAL454 |
| D | GLN459 |
