5EGB
Human PRDM9 allele-A ZnF Domain with Associated Recombination Hotspot DNA Sequence II
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1001 |
| Chain | Residue |
| A | CYS721 |
| A | CYS724 |
| A | HIS737 |
| A | HIS741 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1002 |
| Chain | Residue |
| A | CYS749 |
| A | CYS752 |
| A | HIS765 |
| A | HIS769 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1003 |
| Chain | Residue |
| A | CYS780 |
| A | HIS793 |
| A | HIS797 |
| A | CYS777 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1004 |
| Chain | Residue |
| A | CYS805 |
| A | CYS808 |
| A | HIS821 |
| A | HIS825 |
Functional Information from PROSITE/UniProt
| site_id | PS00028 |
| Number of Residues | 21 |
| Details | ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cre..CgrgFsnkshllrHqrt..H |
| Chain | Residue | Details |
| A | CYS721-HIS741 | |
| A | CYS749-HIS769 | |
| A | CYS777-HIS797 | |
| A | CYS833-HIS853 | |
| A | CYS805-HIS825 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | ZN_FING: C2H2-type 9 => ECO:0000255|PROSITE-ProRule:PRU00042 |
| Chain | Residue | Details |
| A | TYR719-HIS741 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 22 |
| Details | ZN_FING: C2H2-type 10 => ECO:0000255|PROSITE-ProRule:PRU00042 |
| Chain | Residue | Details |
| A | TYR747-HIS769 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 22 |
| Details | ZN_FING: C2H2-type 11 => ECO:0000255|PROSITE-ProRule:PRU00042 |
| Chain | Residue | Details |
| A | TYR775-HIS797 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 22 |
| Details | ZN_FING: C2H2-type 12 => ECO:0000255|PROSITE-ProRule:PRU00042 |
| Chain | Residue | Details |
| A | TYR803-HIS825 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 22 |
| Details | ZN_FING: C2H2-type 13 => ECO:0000255|PROSITE-ProRule:PRU00042 |
| Chain | Residue | Details |
| A | TYR831-HIS853 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26833727, ECO:0007744|PDB:5EGB, ECO:0007744|PDB:5EH2, ECO:0007744|PDB:5EI9 |
| Chain | Residue | Details |
| A | HIS737 | |
| A | HIS741 | |
| A | CYS749 | |
| A | CYS752 | |
| A | HIS765 | |
| A | HIS769 | |
| A | CYS777 | |
| A | CYS780 | |
| A | HIS793 | |
| A | HIS797 | |
| A | CYS805 | |
| A | CYS808 | |
| A | HIS821 | |
| A | HIS825 | |
| A | CYS721 | |
| A | CYS724 |
