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5EF8

Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with panobinostat

Functional Information from GO Data
ChainGOidnamespacecontents
A0000118cellular_componenthistone deacetylase complex
A0004407molecular_functionhistone deacetylase activity
A0006325biological_processchromatin organization
A0016575biological_processhistone deacetylation
B0000118cellular_componenthistone deacetylase complex
B0004407molecular_functionhistone deacetylase activity
B0006325biological_processchromatin organization
B0016575biological_processhistone deacetylation
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN A 2001
ChainResidue
AASP612
AHIS614
AASP705
ALBH2004

site_idAC2
Number of Residues5
Detailsbinding site for residue K A 2002
ChainResidue
AASP610
AASP612
AHIS614
ASER633
ALEU634

site_idAC3
Number of Residues5
Detailsbinding site for residue K A 2003
ChainResidue
APHE623
AASP626
AVAL629
ATYR662
AHOH2122

site_idAC4
Number of Residues14
Detailsbinding site for residue LBH A 2004
ChainResidue
AASP460
AHIS463
APRO464
ASER531
AHIS573
AHIS574
APHE583
AASP612
AHIS614
APHE643
ATYR745
ALEU797
AARG798
AZN2001

site_idAC5
Number of Residues3
Detailsbinding site for residue GOL A 2005
ChainResidue
AARG708
ASER749
AHOH2112

site_idAC6
Number of Residues4
Detailsbinding site for residue ZN B 2001
ChainResidue
BASP612
BHIS614
BASP705
BLBH2004

site_idAC7
Number of Residues5
Detailsbinding site for residue K B 2002
ChainResidue
BASP610
BASP612
BHIS614
BSER633
BLEU634

site_idAC8
Number of Residues6
Detailsbinding site for residue K B 2003
ChainResidue
BPHE623
BASP626
BVAL629
BTYR662
BHOH2109
BHOH2124

site_idAC9
Number of Residues16
Detailsbinding site for residue LBH B 2004
ChainResidue
BASP460
BPRO464
BSER531
BHIS573
BHIS574
BPHE583
BASP612
BHIS614
BPHE643
BASP705
BLEU712
BTYR745
BLEU797
BARG798
BZN2001
BGOL2006

site_idAD1
Number of Residues3
Detailsbinding site for residue GOL B 2005
ChainResidue
BTHR600
BARG601
BARG736

site_idAD2
Number of Residues6
Detailsbinding site for residue GOL B 2006
ChainResidue
BPHE643
BASN645
BHIS684
BPRO688
BLBH2004
BHOH2144

site_idAD3
Number of Residues3
Detailsbinding site for residue EDO B 2007
ChainResidue
BARG451
BALA491
BLEU493

223532

PDB entries from 2024-08-07

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