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5EC3

Structural insight into the catalyitc mechanism of human 4-Hydroxyphenylpyruvate dioxygenase

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0003868molecular_function4-hydroxyphenylpyruvate dioxygenase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0006559biological_processL-phenylalanine catabolic process
A0006572biological_processL-tyrosine catabolic process
A0009072biological_processaromatic amino acid metabolic process
A0016491molecular_functionoxidoreductase activity
A0016701molecular_functionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen
A0042803molecular_functionprotein homodimerization activity
A0046872molecular_functionmetal ion binding
A0051213molecular_functiondioxygenase activity
A0070062cellular_componentextracellular exosome
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue CO A 401
ChainResidue
AHIS183
AHIS266
AGLU349
AHOH623
AHOH706

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues131
DetailsDomain: {"description":"VOC 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01163","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues158
DetailsDomain: {"description":"VOC 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01163","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues3
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues1
DetailsModified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P49429","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P49429","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

242842

PDB entries from 2025-10-08

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