5EC3
Structural insight into the catalyitc mechanism of human 4-Hydroxyphenylpyruvate dioxygenase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0003868 | molecular_function | 4-hydroxyphenylpyruvate dioxygenase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005829 | cellular_component | cytosol |
| A | 0006559 | biological_process | L-phenylalanine catabolic process |
| A | 0006572 | biological_process | tyrosine catabolic process |
| A | 0009072 | biological_process | aromatic amino acid metabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016701 | molecular_function | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051213 | molecular_function | dioxygenase activity |
| A | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue CO A 401 |
| Chain | Residue |
| A | HIS183 |
| A | HIS266 |
| A | GLU349 |
| A | HOH623 |
| A | HOH706 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000305 |
| Chain | Residue | Details |
| A | HIS183 | |
| A | HIS266 | |
| A | GLU349 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylthreonine => ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| A | THR2 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P49429 |
| Chain | Residue | Details |
| A | LYS132 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER211 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P49429 |
| Chain | Residue | Details |
| A | SER226 | |
| A | SER250 |
