5EBX

THE CRYSTAL STRUCTURE OF ERABUTOXIN A AT 2.0 ANGSTROMS RESOLUTION

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0030550	molecular_function	acetylcholine receptor inhibitor activity
A	0035821	biological_process	modulation of process of another organism
A	0090729	molecular_function	toxin activity
A	0099106	molecular_function	ion channel regulator activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 63

Chain	Residue
A	ARG1
A	ASN5
A	LYS15
A	GLU56
A	HOH103
A	HOH112
A	HOH127

---

site_id	CMR
Number of Residues	13
Details	RESIDUES, INCLUDING FOUR CYSTINE LINKAGES, WHICH AID IN MAINTAINING THE UNIQUE TOXIN FOLD CONFORMATION

Chain	Residue
A	CYS3
A	PHE4
A	CYS17
A	CYS24
A	TYR25
A	GLY40
A	CYS41
A	GLY42
A	CYS43
A	CYS54
A	CYS55
A	CYS60
A	ASN61

---

site_id	FNR
Number of Residues	4
Details	RESIDUES IN THE REACTIVE SITE SHOWN CHEMICALLY TO BIND DIRECTLY TO RECEPTOR

Chain	Residue
A	LYS27
A	TRP29
A	ARG33
A	LYS47

---

site_id	RCT
Number of Residues	20
Details	THE SERIES INVARIANT RESIDUES OF THE REACTIVE SITE. FIVE OF THESE RESIDUES (PHE 32, ILE 36, GLU 38, ILE 50, LEU 52) ARE TYPE-CONSERVED THROUGHOUT THE SERIES. THE ENUMERATION IS FOR A 62-RESIDUE TOXIN

Chain	Residue
A	TYR25
A	GLY40
A	CYS41
A	GLY42
A	CYS43
A	PRO44
A	VAL46
A	LYS47
A	GLY49
A	ILE50
A	LEU52
A	LYS27
A	CYS54
A	TRP29
A	ASP31
A	PHE32
A	ARG33
A	GLY34
A	ILE36
A	GLU38

---

Functional Information from PROSITE/UniProt

site_id	PS00272
Number of Residues	19
Details	SNAKE_TOXIN Snake toxins signature. GCg..CPtvkpgikls.CCesE

Chain	Residue	Details
A	GLY40-GLU58

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	Region: {"description":"Loop I","evidences":[{"source":"PubMed","id":"7721859","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	Region: {"description":"Stretch between loop I and loop II","evidences":[{"source":"PubMed","id":"7721859","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	17
Details	Region: {"description":"Loop II","evidences":[{"source":"PubMed","id":"7721859","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	11
Details	Region: {"description":"Loop III","evidences":[{"source":"PubMed","id":"7721859","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Site: {"description":"Moderately important residue for binding to acetylcholine receptor","evidences":[{"source":"PubMed","id":"7721859","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Site: {"description":"Very important residue for binding to acetylcholine receptor","evidences":[{"source":"PubMed","id":"7721859","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	Site: {"description":"Key residue for binding to acetylcholine receptor","evidences":[{"source":"PubMed","id":"7721859","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8419369","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Site: {"description":"Key residue for binding to acetylcholine receptor","evidences":[{"source":"PubMed","id":"8419369","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Site: {"description":"Very important residue for binding to acetylcholine receptor","evidences":[{"source":"PubMed","id":"8419369","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Site: {"description":"Moderately important residue for binding to acetylcholine receptor","evidences":[{"source":"PubMed","id":"8419369","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---