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5EAX

Crystal structure of Dna2 in complex with an ssDNA

Functional Information from GO Data
ChainGOidnamespacecontents
A0000076biological_processDNA replication checkpoint signaling
A0000166molecular_functionnucleotide binding
A0000723biological_processtelomere maintenance
A0000729biological_processDNA double-strand break processing
A0000781cellular_componentchromosome, telomeric region
A0003677molecular_functionDNA binding
A0003678molecular_functionDNA helicase activity
A0003723molecular_functionRNA binding
A0003824molecular_functioncatalytic activity
A0004386molecular_functionhelicase activity
A0004518molecular_functionnuclease activity
A0004519molecular_functionendonuclease activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005760cellular_componentgamma DNA polymerase complex
A0006260biological_processDNA replication
A0006264biological_processmitochondrial DNA replication
A0006281biological_processDNA repair
A0006284biological_processbase-excision repair
A0006974biological_processDNA damage response
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0017108molecular_function5'-flap endonuclease activity
A0017116molecular_functionsingle-stranded DNA helicase activity
A0032201biological_processtelomere maintenance via semi-conservative replication
A0033567biological_processDNA replication, Okazaki fragment processing
A0033892molecular_functiondeoxyribonuclease (pyrimidine dimer) activity
A0042645cellular_componentmitochondrial nucleoid
A0043137biological_processDNA replication, removal of RNA primer
A0043139molecular_function5'-3' DNA helicase activity
A0043504biological_processmitochondrial DNA repair
A0045740biological_processpositive regulation of DNA replication
A0046872molecular_functionmetal ion binding
A0051536molecular_functioniron-sulfur cluster binding
A0051539molecular_function4 iron, 4 sulfur cluster binding
A0071932biological_processreplication fork reversal
A1902990biological_processmitotic telomere maintenance via semi-conservative replication
B0000076biological_processDNA replication checkpoint signaling
B0000166molecular_functionnucleotide binding
B0000723biological_processtelomere maintenance
B0000729biological_processDNA double-strand break processing
B0000781cellular_componentchromosome, telomeric region
B0003677molecular_functionDNA binding
B0003678molecular_functionDNA helicase activity
B0003723molecular_functionRNA binding
B0003824molecular_functioncatalytic activity
B0004386molecular_functionhelicase activity
B0004518molecular_functionnuclease activity
B0004519molecular_functionendonuclease activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005760cellular_componentgamma DNA polymerase complex
B0006260biological_processDNA replication
B0006264biological_processmitochondrial DNA replication
B0006281biological_processDNA repair
B0006284biological_processbase-excision repair
B0006974biological_processDNA damage response
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0017108molecular_function5'-flap endonuclease activity
B0017116molecular_functionsingle-stranded DNA helicase activity
B0032201biological_processtelomere maintenance via semi-conservative replication
B0033567biological_processDNA replication, Okazaki fragment processing
B0033892molecular_functiondeoxyribonuclease (pyrimidine dimer) activity
B0042645cellular_componentmitochondrial nucleoid
B0043137biological_processDNA replication, removal of RNA primer
B0043139molecular_function5'-3' DNA helicase activity
B0043504biological_processmitochondrial DNA repair
B0045740biological_processpositive regulation of DNA replication
B0046872molecular_functionmetal ion binding
B0051536molecular_functioniron-sulfur cluster binding
B0051539molecular_function4 iron, 4 sulfur cluster binding
B0071932biological_processreplication fork reversal
B1902990biological_processmitotic telomere maintenance via semi-conservative replication
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue SF4 A 1101
ChainResidue
ACYS137
AILE387
ACYS394
ACYS397
ACYS403
AMET423

site_idAC2
Number of Residues10
Detailsbinding site for residue ADP A 1102
ChainResidue
AGLN631
AGLY654
ALYS655
ATHR656
ATHR657
ALYS689
ATYR828
AGLY626
ALEU627
AASN628

site_idAC3
Number of Residues7
Detailsbinding site for residue SF4 B 1101
ChainResidue
BCYS137
BARG140
BILE387
BCYS394
BCYS397
BCYS403
BMET423

site_idAC4
Number of Residues10
Detailsbinding site for residue ADP B 1102
ChainResidue
BGLY626
BLEU627
BASN628
BGLN631
BGLY654
BLYS655
BTHR656
BTHR657
BLYS689
BTYR828

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues14
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

242842

PDB entries from 2025-10-08

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