5EA3

Crystal Structure of Inhibitor JNJ-2408068 in Complex with Prefusion RSV F Glycoprotein

Functional Information from GO Data

Chain	GOid	namespace	contents
F	0019064	biological_process	fusion of virus membrane with host plasma membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue NHE F 601

Chain	Residue
F	PHE387
F	PHE477
F	TYR478
F	ASP479
F	ASN496
F	ILE499
F	LEU503

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site_id	AC2
Number of Residues	3
Details	binding site for residue SO4 F 602

Chain	Residue
F	ARG364
F	ASN276
F	ASN277

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site_id	AC3
Number of Residues	3
Details	binding site for residue SO4 F 603

Chain	Residue
F	PHE137
F	ARG339
F	HOH726

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site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 F 604

Chain	Residue
F	SER443
F	LYS445
F	SER466
F	HOH706

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site_id	AC5
Number of Residues	2
Details	binding site for residue SO4 F 605

Chain	Residue
F	VAL239
F	ASN240

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site_id	AC6
Number of Residues	3
Details	binding site for residue SO4 F 606

Chain	Residue
F	ASN444
F	GLY446
F	LYS461

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site_id	AC7
Number of Residues	3
Details	binding site for residue SO4 F 607

Chain	Residue
F	LYS156
F	GLN462
F	GLU463

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site_id	AC8
Number of Residues	11
Details	binding site for residue 5NK F 608

Chain	Residue
F	PHE140
F	PHE140
F	MET396
F	ASP486
F	ASP486
F	ASP486
F	GLU487
F	PHE488
F	PHE488
F	PHE488
F	ASP489

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Cleavage; by host furin-like protease => ECO:0000269|PubMed:11493675, ECO:0000269|PubMed:12127793

Chain	Residue	Details
F	ARG109

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Cleavage; by host furin-like protease => ECO:0000269|PubMed:11369882, ECO:0000269|PubMed:12127793

Chain	Residue	Details
F	ARG136

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site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000269|PubMed:21586636

Chain	Residue	Details
F	ASN27

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site_id	SWS_FT_FI4
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000269|PubMed:21586636, ECO:0000269|PubMed:28469033

Chain	Residue	Details
F	ASN70

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site_id	SWS_FT_FI5
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000255

Chain	Residue	Details
F	ASN116
F	ASN120
F	ASN126

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site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000269|PubMed:21586636, ECO:0000269|PubMed:24179220

Chain	Residue	Details
F	ASN500

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