5E9W

Crystal structure of mRNA cap guanine-N7 methyltransferase obtained by limited proteolysis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
A	0006370	biological_process	7-methylguanosine mRNA capping
B	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
B	0006370	biological_process	7-methylguanosine mRNA capping
C	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
C	0006370	biological_process	7-methylguanosine mRNA capping
D	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
D	0006370	biological_process	7-methylguanosine mRNA capping

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue SAH A 500

Chain	Residue
A	LYS180
A	PHE285
A	VAL286
A	TYR289
A	HOH609
A	HOH615
A	HOH623
A	HOH634
A	GLY205
A	CYS206
A	GLY207
A	ASP227
A	ILE228
A	ASP261
A	SER262
A	GLN284

---

site_id	AC2
Number of Residues	19
Details	binding site for residue SAH B 501

Chain	Residue
B	LYS180
B	GLY205
B	CYS206
B	GLY207
B	ASP227
B	ILE228
B	ASP261
B	SER262
B	GLN284
B	PHE285
B	VAL286
B	TYR289
B	HOH607
B	HOH623
B	HOH634
B	HOH635
B	HOH640
B	HOH646
B	HOH655

---

site_id	AC3
Number of Residues	16
Details	binding site for residue SAH C 501

Chain	Residue
C	LYS180
C	GLY205
C	CYS206
C	GLY207
C	ASP227
C	ILE228
C	ASP261
C	SER262
C	GLN284
C	PHE285
C	VAL286
C	TYR289
C	HOH612
C	HOH613
C	HOH627
C	HOH629

---

site_id	AC4
Number of Residues	16
Details	binding site for residue SAH D 501

Chain	Residue
D	LYS180
D	GLY205
D	GLY207
D	ASP227
D	ILE228
D	ASP261
D	SER262
D	GLN284
D	PHE285
D	VAL286
D	TYR289
D	HOH616
D	HOH619
D	HOH644
D	HOH647
D	HOH662

---

site_id	AC5
Number of Residues	26
Details	binding site for Di-peptide ARG C 246 and GLN D 416

Chain	Residue
B	ARG272
C	PHE170
C	ASN174
C	ASP242
C	LYS244
C	ASN245
C	ARG247
C	LEU412
C	LYS413
C	ARG414
C	MET415
D	PHE170
D	PHE170
D	TYR171
D	ASP242
D	MET243
D	LYS244
D	ASN245
D	ARG247
D	ARG247
D	ASP248
D	SER249
D	LEU412
D	LYS413
D	ARG414
D	MET415

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00895","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00895","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27422871","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3BGV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E9J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E9W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27422871","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3BGV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E9J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E9W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	Site: {"description":"mRNA cap binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00895","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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