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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5E98

Crystal structure of human heparanase in complex with HepMer M04S02a

Functional Information from GO Data
ChainGOidnamespacecontents
A0016020cellular_componentmembrane
A0016798molecular_functionhydrolase activity, acting on glycosyl bonds
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues129
DetailsRegion: {"description":"Required for heterodimerization with the heparanase 8 kDa subunit","evidences":[{"source":"PubMed","id":"12927802","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues16
DetailsRegion: {"description":"Required for transferring proheparanase to the Golgi apparatus, secretion and subsequent enzyme activity and for enhancement of PKB/AKT1 phosphorylation"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues1
DetailsActive site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"28581485","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5E9B","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues1
DetailsActive site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"28581485","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5E97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E98","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E9B","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues10
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15760902","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28581485","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5E9C","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"28581485","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5E9C","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues5
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"28581485","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5E97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E98","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E9B","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14573609","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28581485","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5E8M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E97","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14573609","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14573609","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28581485","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5E8M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E98","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E9B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E9C","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14573609","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16263699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28581485","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5E8M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14573609","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28581485","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5E8M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E98","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E9B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E9C","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"28581485","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5E97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E98","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E9B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E9C","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

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PDB entries from 2025-07-16

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