5E8G

Crystal structure of the DNA binding domain of human transcription factor FLI1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0043565	molecular_function	sequence-specific DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0043565	molecular_function	sequence-specific DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0043565	molecular_function	sequence-specific DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0043565	molecular_function	sequence-specific DNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue CO A 401

Chain	Residue
A	ASP361
A	HIS363
A	HOH501
A	HOH503
A	HOH504

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site_id	AC2
Number of Residues	5
Details	binding site for residue CO B 401

Chain	Residue
C	HOH502
B	ASP361
B	HIS363
B	HOH501
B	HOH502

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site_id	AC3
Number of Residues	5
Details	binding site for residue CO C 401

Chain	Residue
A	HOH502
C	ASP361
C	HIS363
C	HOH501
C	HOH503

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site_id	AC4
Number of Residues	5
Details	binding site for residue CO D 401

Chain	Residue
D	ASP361
D	HIS363
D	HOH501
D	HOH502
D	HOH503

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Functional Information from PROSITE/UniProt

site_id	PS00345
Number of Residues	9
Details	ETS_DOMAIN_1 Ets-domain signature 1. LWQFLLELL

Chain	Residue	Details
A	LEU283-LEU291

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site_id	PS00346
Number of Residues	16
Details	ETS_DOMAIN_2 Ets-domain signature 2. KpnMnYDkLSRALRyY

Chain	Residue	Details
A	LYS327-TYR342

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	320
Details	DNA_BIND: ETS => ECO:0000255|PROSITE-ProRule:PRU00237

Chain	Residue	Details
A	ILE281-ASP361
B	ILE281-ASP361
C	ILE281-ASP361
D	ILE281-ASP361

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