5E6X
Re-refinement of the Crystal Structure of the Plexin-Semaphorin-Integrin Domain/Hybrid Domain/I-EGF1 Segment from the Human Integrin b2 Subunit
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00022 |
| Number of Residues | 12 |
| Details | EGF_1 EGF-like domain signature 1. CrCdtGyiGKnC |
| Chain | Residue | Details |
| A | CYS448-CYS459 |
| site_id | PS00243 |
| Number of Residues | 14 |
| Details | INTEGRIN_BETA Integrins beta chain cysteine-rich domain signature. CsGl..GdCvCgqClC |
| Chain | Residue | Details |
| A | CYS484-CYS497 |
| site_id | PS01186 |
| Number of Residues | 14 |
| Details | EGF_2 EGF-like domain signature 2. CrCdtGYigknce..C |
| Chain | Residue | Details |
| A | CYS448-CYS461 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN |
| Chain | Residue | Details |
| A | PRO353 | |
| A | THR355 | |
| A | ASP451 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: in ADMIDAS binding site => ECO:0000269|PubMed:20033057, ECO:0007744|PDB:3K6S, ECO:0007744|PDB:3K71, ECO:0007744|PDB:3K72 |
| Chain | Residue | Details |
| A | VAL358 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: in ADMIDAS binding site => ECO:0000269|PubMed:20033057, ECO:0000269|PubMed:24385486, ECO:0007744|PDB:3K6S, ECO:0007744|PDB:3K71, ECO:0007744|PDB:3K72, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN |
| Chain | Residue | Details |
| A | THR359 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: in LIMBS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN |
| Chain | Residue | Details |
| A | GLN390 | |
| A | GLY446 | |
| A | CYS448 | |
| A | CYS450 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: in ADMIDAS binding site and liganded-open conformation => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEN |
| Chain | Residue | Details |
| A | SER481 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | BINDING: in ADMIDAS binding site and unliganded-closed conformation => ECO:0000269|PubMed:20033057, ECO:0000269|PubMed:24385486, ECO:0007744|PDB:3K6S, ECO:0007744|PDB:3K71, ECO:0007744|PDB:3K72, ECO:0007744|PDB:4NEH |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Pyrrolidone carboxylic acid => ECO:0000305|PubMed:2954816 |
| Chain | Residue | Details |
| A | GLN1 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973 |
| Chain | Residue | Details |
| A | ASN28 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:20033057, ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN |
| Chain | Residue | Details |
| A | ASN94 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973 |
| Chain | Residue | Details |
| A | ASP429 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU471 | |
| A | ASN479 |
