5E6V

Re-refinement of the Crystal Structure of the Plexin-Semaphorin-Integrin Domain/Hybrid Domain/I-EGF1 Segment from the Human Integrin b2 Subunit

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0007155	biological_process	cell adhesion
A	0007160	biological_process	cell-matrix adhesion
A	0007229	biological_process	integrin-mediated signaling pathway
A	0008305	cellular_component	integrin complex
A	0038023	molecular_function	signaling receptor activity

Functional Information from PROSITE/UniProt

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CrCdtGyiGKnC

Chain	Residue	Details
A	CYS448-CYS459

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site_id	PS01186
Number of Residues	12
Details	EGF_2 EGF-like domain signature 2. CrCdtGYigkn....C

Chain	Residue	Details
A	CYS448-CYS459

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN

Chain	Residue	Details
A	PRO353
A	THR355
A	ASP451

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: in ADMIDAS binding site => ECO:0000269|PubMed:20033057, ECO:0007744|PDB:3K6S, ECO:0007744|PDB:3K71, ECO:0007744|PDB:3K72

Chain	Residue	Details
A	VAL358

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: in ADMIDAS binding site => ECO:0000269|PubMed:20033057, ECO:0000269|PubMed:24385486, ECO:0007744|PDB:3K6S, ECO:0007744|PDB:3K71, ECO:0007744|PDB:3K72, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN

Chain	Residue	Details
A	THR359

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site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: in LIMBS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN

Chain	Residue	Details
A	GLN390
A	GLY446
A	CYS448
A	CYS450

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site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: in ADMIDAS binding site and liganded-open conformation => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEN

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	1
Details	BINDING: in ADMIDAS binding site and unliganded-closed conformation => ECO:0000269|PubMed:20033057, ECO:0000269|PubMed:24385486, ECO:0007744|PDB:3K6S, ECO:0007744|PDB:3K71, ECO:0007744|PDB:3K72, ECO:0007744|PDB:4NEH

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Pyrrolidone carboxylic acid => ECO:0000305|PubMed:2954816

Chain	Residue	Details
A	PCA1

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site_id	SWS_FT_FI8
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973

Chain	Residue	Details
A	ASN28

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site_id	SWS_FT_FI9
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:20033057, ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN

Chain	Residue	Details
A	ASN94

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site_id	SWS_FT_FI10
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973

Chain	Residue	Details
A	ASP429

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site_id	SWS_FT_FI11
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain

Residue

Details

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