5E4N
3-Deoxy-D-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis with D-tyrosine bound in the tyrosine and phenylalanine binding sites
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0008652 | biological_process | amino acid biosynthetic process |
A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
A | 0009274 | cellular_component | peptidoglycan-based cell wall |
A | 0009423 | biological_process | chorismate biosynthetic process |
A | 0016740 | molecular_function | transferase activity |
A | 0030145 | molecular_function | manganese ion binding |
A | 0046872 | molecular_function | metal ion binding |
A | 0051260 | biological_process | protein homooligomerization |
B | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005829 | cellular_component | cytosol |
B | 0005886 | cellular_component | plasma membrane |
B | 0008652 | biological_process | amino acid biosynthetic process |
B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
B | 0009274 | cellular_component | peptidoglycan-based cell wall |
B | 0009423 | biological_process | chorismate biosynthetic process |
B | 0016740 | molecular_function | transferase activity |
B | 0030145 | molecular_function | manganese ion binding |
B | 0046872 | molecular_function | metal ion binding |
B | 0051260 | biological_process | protein homooligomerization |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 9 |
Details | binding site for residue SO4 A 501 |
Chain | Residue |
A | GLY282 |
A | GLU283 |
A | LYS306 |
A | ARG337 |
A | HOH618 |
A | HOH649 |
A | HOH697 |
A | HOH708 |
A | HOH783 |
site_id | AC2 |
Number of Residues | 2 |
Details | binding site for residue CL A 502 |
Chain | Residue |
A | ASP140 |
A | ALA141 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue MN A 503 |
Chain | Residue |
A | CYS87 |
A | HIS369 |
A | GLU411 |
A | ASP441 |
A | HOH709 |
site_id | AC4 |
Number of Residues | 1 |
Details | binding site for residue CL A 504 |
Chain | Residue |
A | ARG49 |
site_id | AC5 |
Number of Residues | 9 |
Details | binding site for residue DTY A 505 |
Chain | Residue |
A | PHE91 |
A | ARG171 |
A | ALA174 |
A | ASN175 |
A | HOH646 |
A | HOH655 |
B | TYR173 |
B | ALA174 |
B | HOH755 |
site_id | AC6 |
Number of Residues | 7 |
Details | binding site for residue SO4 B 501 |
Chain | Residue |
B | GLY282 |
B | GLU283 |
B | LYS306 |
B | ARG337 |
B | HIS369 |
B | HOH671 |
B | HOH704 |
site_id | AC7 |
Number of Residues | 5 |
Details | binding site for residue SO4 B 502 |
Chain | Residue |
B | ARG135 |
B | SER136 |
B | ALA137 |
B | ARG284 |
B | HOH622 |
site_id | AC8 |
Number of Residues | 8 |
Details | binding site for residue SO4 B 503 |
Chain | Residue |
B | PRO16 |
B | PRO17 |
B | LEU18 |
B | ARG23 |
B | ASP158 |
B | ALA159 |
B | DTY508 |
B | HOH603 |
site_id | AC9 |
Number of Residues | 2 |
Details | binding site for residue CL B 504 |
Chain | Residue |
A | HOH605 |
B | SER62 |
site_id | AD1 |
Number of Residues | 4 |
Details | binding site for residue MN B 505 |
Chain | Residue |
B | CYS87 |
B | HIS369 |
B | GLU411 |
B | ASP441 |
site_id | AD2 |
Number of Residues | 1 |
Details | binding site for residue CL B 506 |
Chain | Residue |
B | ARG100 |
site_id | AD3 |
Number of Residues | 9 |
Details | binding site for residue DTY B 507 |
Chain | Residue |
A | LEU12 |
A | TYR173 |
A | ALA174 |
B | PHE91 |
B | ARG171 |
B | ALA174 |
B | ASN175 |
B | HOH683 |
B | HOH732 |
site_id | AD4 |
Number of Residues | 10 |
Details | binding site for residue DTY B 508 |
Chain | Residue |
B | PRO16 |
B | LEU18 |
B | ARG23 |
B | LEU26 |
B | GLU53 |
B | ARG256 |
B | SO4503 |
B | HOH601 |
B | HOH654 |
B | HOH727 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 16 |
Details | BINDING: BINDING => ECO:0000269|PubMed:16288916, ECO:0007744|PDB:2B7O |
Chain | Residue | Details |
A | CYS87 | |
B | ARG126 | |
B | GLU283 | |
B | LYS306 | |
B | ARG337 | |
B | HIS369 | |
B | GLU411 | |
B | ASP441 | |
A | ARG126 | |
A | GLU283 | |
A | LYS306 | |
A | ARG337 | |
A | HIS369 | |
A | GLU411 | |
A | ASP441 | |
B | CYS87 |