5E4N
3-Deoxy-D-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis with D-tyrosine bound in the tyrosine and phenylalanine binding sites
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0009274 | cellular_component | peptidoglycan-based cell wall |
| A | 0009423 | biological_process | chorismate biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051260 | biological_process | protein homooligomerization |
| B | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0009274 | cellular_component | peptidoglycan-based cell wall |
| B | 0009423 | biological_process | chorismate biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051260 | biological_process | protein homooligomerization |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 501 |
| Chain | Residue |
| A | GLY282 |
| A | GLU283 |
| A | LYS306 |
| A | ARG337 |
| A | HOH618 |
| A | HOH649 |
| A | HOH697 |
| A | HOH708 |
| A | HOH783 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 502 |
| Chain | Residue |
| A | ASP140 |
| A | ALA141 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue MN A 503 |
| Chain | Residue |
| A | CYS87 |
| A | HIS369 |
| A | GLU411 |
| A | ASP441 |
| A | HOH709 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 504 |
| Chain | Residue |
| A | ARG49 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue DTY A 505 |
| Chain | Residue |
| A | PHE91 |
| A | ARG171 |
| A | ALA174 |
| A | ASN175 |
| A | HOH646 |
| A | HOH655 |
| B | TYR173 |
| B | ALA174 |
| B | HOH755 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 501 |
| Chain | Residue |
| B | GLY282 |
| B | GLU283 |
| B | LYS306 |
| B | ARG337 |
| B | HIS369 |
| B | HOH671 |
| B | HOH704 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 502 |
| Chain | Residue |
| B | ARG135 |
| B | SER136 |
| B | ALA137 |
| B | ARG284 |
| B | HOH622 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 503 |
| Chain | Residue |
| B | PRO16 |
| B | PRO17 |
| B | LEU18 |
| B | ARG23 |
| B | ASP158 |
| B | ALA159 |
| B | DTY508 |
| B | HOH603 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 504 |
| Chain | Residue |
| A | HOH605 |
| B | SER62 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue MN B 505 |
| Chain | Residue |
| B | CYS87 |
| B | HIS369 |
| B | GLU411 |
| B | ASP441 |
| site_id | AD2 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 506 |
| Chain | Residue |
| B | ARG100 |
| site_id | AD3 |
| Number of Residues | 9 |
| Details | binding site for residue DTY B 507 |
| Chain | Residue |
| A | LEU12 |
| A | TYR173 |
| A | ALA174 |
| B | PHE91 |
| B | ARG171 |
| B | ALA174 |
| B | ASN175 |
| B | HOH683 |
| B | HOH732 |
| site_id | AD4 |
| Number of Residues | 10 |
| Details | binding site for residue DTY B 508 |
| Chain | Residue |
| B | PRO16 |
| B | LEU18 |
| B | ARG23 |
| B | LEU26 |
| B | GLU53 |
| B | ARG256 |
| B | SO4503 |
| B | HOH601 |
| B | HOH654 |
| B | HOH727 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16288916","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2B7O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
