5E2P

FACTOR XIA IN COMPLEX WITH THE INHIBITOR N-[(1S)-1-benzyl-2-[2-[5-chloro-2-(tetrazol-1-yl)phenyl]ethylamino]-2-oxo-ethyl]-4-hydroxy-2-oxo-1H-quinoline-6-carboxamide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	28
Details	binding site for residue 7P0 A 301

Chain	Residue
A	ARG39
A	LYS192
A	GLY193
A	ASP194
A	SER195
A	THR213
A	SER214
A	TRP215
A	GLY216
A	GLY218
A	CYS219
A	HIS40
A	GLY226
A	VAL227
A	EDO303
A	EDO307
A	EDO310
A	HOH441
A	HOH466
A	HOH515
A	HOH516
A	LEU41
A	HIS57
A	TYR143
A	ILE151
A	ASP189
A	ALA190
A	CYS191

---

site_id	AC2
Number of Residues	4
Details	binding site for residue SO4 A 302

Chain	Residue
A	ARG170
A	ARG170
A	ARG184
A	ARG184

---

site_id	AC3
Number of Residues	5
Details	binding site for residue EDO A 303

Chain	Residue
A	LYS192
A	7P0301
A	EDO307
A	EDO310
A	HOH510

---

site_id	AC4
Number of Residues	4
Details	binding site for residue EDO A 304

Chain	Residue
A	ASN49
A	VAL112
A	GLY113
A	TYR114

---

site_id	AC5
Number of Residues	7
Details	binding site for residue EDO A 305

Chain	Residue
A	ARG24
A	SER99
A	GLY173
A	LYS175
A	HOH431
A	HOH445
A	HOH485

---

site_id	AC6
Number of Residues	8
Details	binding site for residue EDO A 306

Chain	Residue
A	ARG24
A	GLY25
A	TRP27
A	PRO28
A	ILE70
A	LEU71
A	SER117
A	HOH424

---

site_id	AC7
Number of Residues	7
Details	binding site for residue EDO A 307

Chain	Residue
A	SER81
A	GLY216
A	GLU217
A	GLY218
A	7P0301
A	EDO303
A	EDO308

---

site_id	AC8
Number of Residues	7
Details	binding site for residue EDO A 308

Chain	Residue
A	GLU98
A	HIS174
A	TRP215
A	GLY216
A	GLU217
A	EDO307
A	HOH521

---

site_id	AC9
Number of Residues	1
Details	binding site for residue EDO A 309

Chain	Residue
A	HIS178

---

site_id	AD1
Number of Residues	7
Details	binding site for residue EDO A 310

Chain	Residue
A	HIS57
A	SER214
A	TRP215
A	7P0301
A	EDO303
A	EDO312
A	HOH521

---

site_id	AD2
Number of Residues	7
Details	binding site for residue EDO A 311

Chain	Residue
A	GLU167
A	ARG170
A	GLY184
A	TYR184
A	ARG184
A	PRO225
A	HOH403

---

site_id	AD3
Number of Residues	7
Details	binding site for residue EDO A 312

Chain	Residue
A	TYR94
A	MET96
A	ALA97
A	GLU98
A	SER117
A	EDO310
A	HOH453

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
A	LEU53-CYS58

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAckGDSGGPLS

Chain	Residue	Details
A	ASP189-SER200

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	235
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Charge relay system"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25092234","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1998667","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25092234","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---