5E26

Crystal structure of human PANK2: the catalytic core domain in complex with pantothenate and adenosine diphosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0015937	biological_process	coenzyme A biosynthetic process
B	0005524	molecular_function	ATP binding
B	0015937	biological_process	coenzyme A biosynthetic process
C	0005524	molecular_function	ATP binding
C	0015937	biological_process	coenzyme A biosynthetic process
D	0005524	molecular_function	ATP binding
D	0015937	biological_process	coenzyme A biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue ADP A 601

Chain	Residue
A	GLY219
A	GLY416
A	PHE419
A	PHE431
A	GLU432
A	ASN522
A	PHE523
A	ARG525
A	HOH734
A	HOH735
A	GLY220
A	THR221
A	LEU222
A	LYS224
A	ARG286
A	GLY391
A	SER392
A	GLY415

---

site_id	AC2
Number of Residues	9
Details	binding site for residue PAU A 602

Chain	Residue
A	GLU338
A	GLY393
A	VAL394
A	SER395
A	ARG407
A	GLY410
A	THR411
A	HOH734
B	ALA469

---

site_id	AC3
Number of Residues	4
Details	binding site for residue GOL A 603

Chain	Residue
A	SER477
A	LYS478
A	GLU479
B	HIS290

---

site_id	AC4
Number of Residues	12
Details	binding site for residue PAU B 601

Chain	Residue
A	ALA469
A	HOH703
B	GLU338
B	GLY393
B	VAL394
B	SER395
B	ARG407
B	GLY410
B	THR411
B	HOH712
B	HOH721
B	HOH743

---

site_id	AC5
Number of Residues	20
Details	binding site for residue ADP B 602

Chain	Residue
B	GLY219
B	GLY220
B	THR221
B	LEU222
B	LYS224
B	ARG286
B	GLY391
B	SER392
B	GLY415
B	GLY416
B	PHE419
B	PHE431
B	GLY521
B	ASN522
B	PHE523
B	ARG525
B	HOH712
B	HOH715
B	HOH721
B	HOH750

---

site_id	AC6
Number of Residues	3
Details	binding site for residue CL B 603

Chain	Residue
B	TYR227
B	PRO230
B	ARG249

---

site_id	AC7
Number of Residues	22
Details	binding site for residue ADP C 601

Chain	Residue
C	GLY219
C	GLY220
C	THR221
C	LEU222
C	LYS224
C	GLY391
C	SER392
C	GLY415
C	GLY416
C	PHE431
C	GLU432
C	ASN522
C	PHE523
C	ARG525
C	HOH702
C	HOH705
C	HOH711
C	HOH727
C	HOH735
C	HOH740
C	HOH747
C	HOH757

---

site_id	AC8
Number of Residues	11
Details	binding site for residue PAU C 602

Chain	Residue
C	GLU338
C	GLY393
C	VAL394
C	SER395
C	ARG407
C	GLY410
C	THR411
C	HOH727
C	HOH740
D	ALA469
D	HOH716

---

site_id	AC9
Number of Residues	12
Details	binding site for residue PAU D 601

Chain	Residue
C	ALA469
C	HOH718
D	GLU338
D	GLY393
D	VAL394
D	SER395
D	ARG407
D	GLY410
D	THR411
D	SER412
D	HOH705
D	HOH732

---

site_id	AD1
Number of Residues	18
Details	binding site for residue ADP D 602

Chain	Residue
D	GLY219
D	GLY220
D	THR221
D	LEU222
D	LYS224
D	GLY391
D	SER392
D	GLY415
D	GLY416
D	PHE431
D	ASN522
D	PHE523
D	ARG525
D	HOH701
D	HOH705
D	HOH715
D	HOH728
D	HOH732

---

site_id	AD2
Number of Residues	4
Details	binding site for residue GOL D 603

Chain	Residue
D	ASP350
D	ASP378
D	LEU379
D	LEU549

---

site_id	AD3
Number of Residues	3
Details	binding site for residue CL D 604

Chain	Residue
D	TYR227
D	ARG249
D	HOH734

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	28
Details	Motif: {"description":"Nuclear export signal","evidences":[{"source":"PubMed","id":"23152917","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"Q9H999","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8TE04","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---