5E1M
Crystal structure of NTMT1 in complex with PPKRIA peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0006480 | biological_process | N-terminal protein amino acid methylation |
| A | 0007051 | biological_process | spindle organization |
| A | 0007059 | biological_process | chromosome segregation |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008276 | molecular_function | protein methyltransferase activity |
| A | 0018013 | biological_process | N-terminal peptidyl-glycine methylation |
| A | 0018016 | biological_process | N-terminal peptidyl-proline dimethylation |
| A | 0032259 | biological_process | methylation |
| A | 0035572 | biological_process | N-terminal peptidyl-serine dimethylation |
| A | 0035573 | biological_process | N-terminal peptidyl-serine trimethylation |
| A | 0042054 | molecular_function | histone methyltransferase activity |
| A | 0071885 | molecular_function | N-terminal protein N-methyltransferase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006338 | biological_process | chromatin remodeling |
| B | 0006480 | biological_process | N-terminal protein amino acid methylation |
| B | 0007051 | biological_process | spindle organization |
| B | 0007059 | biological_process | chromosome segregation |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0008276 | molecular_function | protein methyltransferase activity |
| B | 0018013 | biological_process | N-terminal peptidyl-glycine methylation |
| B | 0018016 | biological_process | N-terminal peptidyl-proline dimethylation |
| B | 0032259 | biological_process | methylation |
| B | 0035572 | biological_process | N-terminal peptidyl-serine dimethylation |
| B | 0035573 | biological_process | N-terminal peptidyl-serine trimethylation |
| B | 0042054 | molecular_function | histone methyltransferase activity |
| B | 0071885 | molecular_function | N-terminal protein N-methyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue SAH A 301 |
| Chain | Residue |
| A | TRP20 |
| A | PHE96 |
| A | GLY118 |
| A | LEU119 |
| A | GLN120 |
| A | GLN135 |
| A | TRP136 |
| A | VAL137 |
| A | HIS140 |
| A | HOH434 |
| A | HOH498 |
| A | MET30 |
| A | HOH514 |
| A | GLY69 |
| A | GLY71 |
| A | ARG74 |
| A | ILE75 |
| A | ASP91 |
| A | ILE92 |
| A | THR93 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue GOL A 302 |
| Chain | Residue |
| A | TRP136 |
| A | VAL137 |
| A | ILE138 |
| A | GLY139 |
| A | ASP167 |
| A | ASN168 |
| A | SER182 |
| A | VAL183 |
| A | HOH448 |
| A | HOH450 |
| D | PRO1 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 303 |
| Chain | Residue |
| A | GLU86 |
| A | ARG112 |
| A | HOH460 |
| A | HOH503 |
| A | HOH512 |
| B | ARG46 |
| site_id | AC4 |
| Number of Residues | 20 |
| Details | binding site for residue SAH B 301 |
| Chain | Residue |
| B | TRP20 |
| B | MET30 |
| B | GLY69 |
| B | GLY71 |
| B | ARG74 |
| B | ILE75 |
| B | ASP91 |
| B | ILE92 |
| B | THR93 |
| B | PHE96 |
| B | CYS117 |
| B | GLY118 |
| B | LEU119 |
| B | GLN120 |
| B | GLN135 |
| B | TRP136 |
| B | VAL137 |
| B | HIS140 |
| B | HOH415 |
| B | HOH486 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | binding site for residue GOL B 302 |
| Chain | Residue |
| B | TRP136 |
| B | VAL137 |
| B | ILE138 |
| B | GLY139 |
| B | ASP167 |
| B | ASN168 |
| B | SER182 |
| B | VAL183 |
| B | CYS184 |
| B | HOH419 |
| B | HOH423 |
| E | PRO1 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26543159, ECO:0000269|PubMed:26543161, ECO:0007744|PDB:2EX4, ECO:0007744|PDB:5CVD, ECO:0007744|PDB:5CVE, ECO:0007744|PDB:5E1D, ECO:0007744|PDB:5E1M, ECO:0007744|PDB:5E1O, ECO:0007744|PDB:5E2A, ECO:0007744|PDB:5E2B |
| Chain | Residue | Details |
| A | GLY69 | |
| B | GLN135 | |
| A | ARG74 | |
| A | ASP91 | |
| A | LEU119 | |
| A | GLN135 | |
| B | GLY69 | |
| B | ARG74 | |
| B | ASP91 | |
| B | LEU119 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylthreonine; in N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed => ECO:0000269|Ref.5, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895 |
| Chain | Residue | Details |
| A | THR2 | |
| B | THR2 |
