5E0S

crystal structure of the active form of the proteolytic complex clpP1 and clpP2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004176	molecular_function	ATP-dependent peptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006508	biological_process	proteolysis
A	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0009368	cellular_component	endopeptidase Clp complex
A	0016787	molecular_function	hydrolase activity
A	0051117	molecular_function	ATPase binding
B	0004176	molecular_function	ATP-dependent peptidase activity
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006508	biological_process	proteolysis
B	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
B	0008233	molecular_function	peptidase activity
B	0008236	molecular_function	serine-type peptidase activity
B	0009274	cellular_component	peptidoglycan-based cell wall
B	0009368	cellular_component	endopeptidase Clp complex
B	0016787	molecular_function	hydrolase activity
B	0051117	molecular_function	ATPase binding
C	0004176	molecular_function	ATP-dependent peptidase activity
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006508	biological_process	proteolysis
C	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
C	0008233	molecular_function	peptidase activity
C	0008236	molecular_function	serine-type peptidase activity
C	0009274	cellular_component	peptidoglycan-based cell wall
C	0009368	cellular_component	endopeptidase Clp complex
C	0016787	molecular_function	hydrolase activity
C	0051117	molecular_function	ATPase binding
D	0004176	molecular_function	ATP-dependent peptidase activity
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006508	biological_process	proteolysis
D	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
D	0008233	molecular_function	peptidase activity
D	0008236	molecular_function	serine-type peptidase activity
D	0009274	cellular_component	peptidoglycan-based cell wall
D	0009368	cellular_component	endopeptidase Clp complex
D	0016787	molecular_function	hydrolase activity
D	0051117	molecular_function	ATPase binding
E	0004176	molecular_function	ATP-dependent peptidase activity
E	0004252	molecular_function	serine-type endopeptidase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006508	biological_process	proteolysis
E	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
E	0008233	molecular_function	peptidase activity
E	0008236	molecular_function	serine-type peptidase activity
E	0009274	cellular_component	peptidoglycan-based cell wall
E	0009368	cellular_component	endopeptidase Clp complex
E	0016787	molecular_function	hydrolase activity
E	0051117	molecular_function	ATPase binding
F	0004176	molecular_function	ATP-dependent peptidase activity
F	0004252	molecular_function	serine-type endopeptidase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006508	biological_process	proteolysis
F	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
F	0008233	molecular_function	peptidase activity
F	0008236	molecular_function	serine-type peptidase activity
F	0009274	cellular_component	peptidoglycan-based cell wall
F	0009368	cellular_component	endopeptidase Clp complex
F	0016787	molecular_function	hydrolase activity
F	0051117	molecular_function	ATPase binding
G	0004176	molecular_function	ATP-dependent peptidase activity
G	0004252	molecular_function	serine-type endopeptidase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0006508	biological_process	proteolysis
G	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
G	0008233	molecular_function	peptidase activity
G	0008236	molecular_function	serine-type peptidase activity
G	0009274	cellular_component	peptidoglycan-based cell wall
G	0009368	cellular_component	endopeptidase Clp complex
G	0016787	molecular_function	hydrolase activity
G	0051117	molecular_function	ATPase binding
H	0004176	molecular_function	ATP-dependent peptidase activity
H	0004252	molecular_function	serine-type endopeptidase activity
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006508	biological_process	proteolysis
H	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
H	0008233	molecular_function	peptidase activity
H	0008236	molecular_function	serine-type peptidase activity
H	0009368	cellular_component	endopeptidase Clp complex
H	0016787	molecular_function	hydrolase activity
H	0051117	molecular_function	ATPase binding
I	0004176	molecular_function	ATP-dependent peptidase activity
I	0004252	molecular_function	serine-type endopeptidase activity
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005886	cellular_component	plasma membrane
I	0006508	biological_process	proteolysis
I	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
I	0008233	molecular_function	peptidase activity
I	0008236	molecular_function	serine-type peptidase activity
I	0009368	cellular_component	endopeptidase Clp complex
I	0016787	molecular_function	hydrolase activity
I	0051117	molecular_function	ATPase binding
J	0004176	molecular_function	ATP-dependent peptidase activity
J	0004252	molecular_function	serine-type endopeptidase activity
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005886	cellular_component	plasma membrane
J	0006508	biological_process	proteolysis
J	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
J	0008233	molecular_function	peptidase activity
J	0008236	molecular_function	serine-type peptidase activity
J	0009368	cellular_component	endopeptidase Clp complex
J	0016787	molecular_function	hydrolase activity
J	0051117	molecular_function	ATPase binding
K	0004176	molecular_function	ATP-dependent peptidase activity
K	0004252	molecular_function	serine-type endopeptidase activity
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005886	cellular_component	plasma membrane
K	0006508	biological_process	proteolysis
K	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
K	0008233	molecular_function	peptidase activity
K	0008236	molecular_function	serine-type peptidase activity
K	0009368	cellular_component	endopeptidase Clp complex
K	0016787	molecular_function	hydrolase activity
K	0051117	molecular_function	ATPase binding
L	0004176	molecular_function	ATP-dependent peptidase activity
L	0004252	molecular_function	serine-type endopeptidase activity
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005886	cellular_component	plasma membrane
L	0006508	biological_process	proteolysis
L	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
L	0008233	molecular_function	peptidase activity
L	0008236	molecular_function	serine-type peptidase activity
L	0009368	cellular_component	endopeptidase Clp complex
L	0016787	molecular_function	hydrolase activity
L	0051117	molecular_function	ATPase binding
M	0004176	molecular_function	ATP-dependent peptidase activity
M	0004252	molecular_function	serine-type endopeptidase activity
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0005886	cellular_component	plasma membrane
M	0006508	biological_process	proteolysis
M	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
M	0008233	molecular_function	peptidase activity
M	0008236	molecular_function	serine-type peptidase activity
M	0009368	cellular_component	endopeptidase Clp complex
M	0016787	molecular_function	hydrolase activity
M	0051117	molecular_function	ATPase binding
N	0004176	molecular_function	ATP-dependent peptidase activity
N	0004252	molecular_function	serine-type endopeptidase activity
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005886	cellular_component	plasma membrane
N	0006508	biological_process	proteolysis
N	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
N	0008233	molecular_function	peptidase activity
N	0008236	molecular_function	serine-type peptidase activity
N	0009368	cellular_component	endopeptidase Clp complex
N	0016787	molecular_function	hydrolase activity
N	0051117	molecular_function	ATPase binding
a	0004176	molecular_function	ATP-dependent peptidase activity
a	0004252	molecular_function	serine-type endopeptidase activity
a	0005515	molecular_function	protein binding
a	0005737	cellular_component	cytoplasm
a	0005829	cellular_component	cytosol
a	0005886	cellular_component	plasma membrane
a	0006508	biological_process	proteolysis
a	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
a	0008233	molecular_function	peptidase activity
a	0008236	molecular_function	serine-type peptidase activity
a	0009274	cellular_component	peptidoglycan-based cell wall
a	0009368	cellular_component	endopeptidase Clp complex
a	0016787	molecular_function	hydrolase activity
a	0051117	molecular_function	ATPase binding
b	0004176	molecular_function	ATP-dependent peptidase activity
b	0004252	molecular_function	serine-type endopeptidase activity
b	0005515	molecular_function	protein binding
b	0005737	cellular_component	cytoplasm
b	0005829	cellular_component	cytosol
b	0005886	cellular_component	plasma membrane
b	0006508	biological_process	proteolysis
b	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
b	0008233	molecular_function	peptidase activity
b	0008236	molecular_function	serine-type peptidase activity
b	0009274	cellular_component	peptidoglycan-based cell wall
b	0009368	cellular_component	endopeptidase Clp complex
b	0016787	molecular_function	hydrolase activity
b	0051117	molecular_function	ATPase binding
c	0004176	molecular_function	ATP-dependent peptidase activity
c	0004252	molecular_function	serine-type endopeptidase activity
c	0005515	molecular_function	protein binding
c	0005737	cellular_component	cytoplasm
c	0005829	cellular_component	cytosol
c	0005886	cellular_component	plasma membrane
c	0006508	biological_process	proteolysis
c	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
c	0008233	molecular_function	peptidase activity
c	0008236	molecular_function	serine-type peptidase activity
c	0009274	cellular_component	peptidoglycan-based cell wall
c	0009368	cellular_component	endopeptidase Clp complex
c	0016787	molecular_function	hydrolase activity
c	0051117	molecular_function	ATPase binding
d	0004176	molecular_function	ATP-dependent peptidase activity
d	0004252	molecular_function	serine-type endopeptidase activity
d	0005515	molecular_function	protein binding
d	0005737	cellular_component	cytoplasm
d	0005829	cellular_component	cytosol
d	0005886	cellular_component	plasma membrane
d	0006508	biological_process	proteolysis
d	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
d	0008233	molecular_function	peptidase activity
d	0008236	molecular_function	serine-type peptidase activity
d	0009274	cellular_component	peptidoglycan-based cell wall
d	0009368	cellular_component	endopeptidase Clp complex
d	0016787	molecular_function	hydrolase activity
d	0051117	molecular_function	ATPase binding
e	0004176	molecular_function	ATP-dependent peptidase activity
e	0004252	molecular_function	serine-type endopeptidase activity
e	0005515	molecular_function	protein binding
e	0005737	cellular_component	cytoplasm
e	0005829	cellular_component	cytosol
e	0005886	cellular_component	plasma membrane
e	0006508	biological_process	proteolysis
e	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
e	0008233	molecular_function	peptidase activity
e	0008236	molecular_function	serine-type peptidase activity
e	0009274	cellular_component	peptidoglycan-based cell wall
e	0009368	cellular_component	endopeptidase Clp complex
e	0016787	molecular_function	hydrolase activity
e	0051117	molecular_function	ATPase binding
f	0004176	molecular_function	ATP-dependent peptidase activity
f	0004252	molecular_function	serine-type endopeptidase activity
f	0005515	molecular_function	protein binding
f	0005737	cellular_component	cytoplasm
f	0005829	cellular_component	cytosol
f	0005886	cellular_component	plasma membrane
f	0006508	biological_process	proteolysis
f	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
f	0008233	molecular_function	peptidase activity
f	0008236	molecular_function	serine-type peptidase activity
f	0009274	cellular_component	peptidoglycan-based cell wall
f	0009368	cellular_component	endopeptidase Clp complex
f	0016787	molecular_function	hydrolase activity
f	0051117	molecular_function	ATPase binding
g	0004176	molecular_function	ATP-dependent peptidase activity
g	0004252	molecular_function	serine-type endopeptidase activity
g	0005515	molecular_function	protein binding
g	0005737	cellular_component	cytoplasm
g	0005829	cellular_component	cytosol
g	0005886	cellular_component	plasma membrane
g	0006508	biological_process	proteolysis
g	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
g	0008233	molecular_function	peptidase activity
g	0008236	molecular_function	serine-type peptidase activity
g	0009274	cellular_component	peptidoglycan-based cell wall
g	0009368	cellular_component	endopeptidase Clp complex
g	0016787	molecular_function	hydrolase activity
g	0051117	molecular_function	ATPase binding
h	0004176	molecular_function	ATP-dependent peptidase activity
h	0004252	molecular_function	serine-type endopeptidase activity
h	0005737	cellular_component	cytoplasm
h	0005829	cellular_component	cytosol
h	0005886	cellular_component	plasma membrane
h	0006508	biological_process	proteolysis
h	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
h	0008233	molecular_function	peptidase activity
h	0008236	molecular_function	serine-type peptidase activity
h	0009368	cellular_component	endopeptidase Clp complex
h	0016787	molecular_function	hydrolase activity
h	0051117	molecular_function	ATPase binding
i	0004176	molecular_function	ATP-dependent peptidase activity
i	0004252	molecular_function	serine-type endopeptidase activity
i	0005737	cellular_component	cytoplasm
i	0005829	cellular_component	cytosol
i	0005886	cellular_component	plasma membrane
i	0006508	biological_process	proteolysis
i	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
i	0008233	molecular_function	peptidase activity
i	0008236	molecular_function	serine-type peptidase activity
i	0009368	cellular_component	endopeptidase Clp complex
i	0016787	molecular_function	hydrolase activity
i	0051117	molecular_function	ATPase binding
j	0004176	molecular_function	ATP-dependent peptidase activity
j	0004252	molecular_function	serine-type endopeptidase activity
j	0005737	cellular_component	cytoplasm
j	0005829	cellular_component	cytosol
j	0005886	cellular_component	plasma membrane
j	0006508	biological_process	proteolysis
j	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
j	0008233	molecular_function	peptidase activity
j	0008236	molecular_function	serine-type peptidase activity
j	0009368	cellular_component	endopeptidase Clp complex
j	0016787	molecular_function	hydrolase activity
j	0051117	molecular_function	ATPase binding
k	0004176	molecular_function	ATP-dependent peptidase activity
k	0004252	molecular_function	serine-type endopeptidase activity
k	0005737	cellular_component	cytoplasm
k	0005829	cellular_component	cytosol
k	0005886	cellular_component	plasma membrane
k	0006508	biological_process	proteolysis
k	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
k	0008233	molecular_function	peptidase activity
k	0008236	molecular_function	serine-type peptidase activity
k	0009368	cellular_component	endopeptidase Clp complex
k	0016787	molecular_function	hydrolase activity
k	0051117	molecular_function	ATPase binding
l	0004176	molecular_function	ATP-dependent peptidase activity
l	0004252	molecular_function	serine-type endopeptidase activity
l	0005737	cellular_component	cytoplasm
l	0005829	cellular_component	cytosol
l	0005886	cellular_component	plasma membrane
l	0006508	biological_process	proteolysis
l	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
l	0008233	molecular_function	peptidase activity
l	0008236	molecular_function	serine-type peptidase activity
l	0009368	cellular_component	endopeptidase Clp complex
l	0016787	molecular_function	hydrolase activity
l	0051117	molecular_function	ATPase binding
m	0004176	molecular_function	ATP-dependent peptidase activity
m	0004252	molecular_function	serine-type endopeptidase activity
m	0005737	cellular_component	cytoplasm
m	0005829	cellular_component	cytosol
m	0005886	cellular_component	plasma membrane
m	0006508	biological_process	proteolysis
m	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
m	0008233	molecular_function	peptidase activity
m	0008236	molecular_function	serine-type peptidase activity
m	0009368	cellular_component	endopeptidase Clp complex
m	0016787	molecular_function	hydrolase activity
m	0051117	molecular_function	ATPase binding
n	0004176	molecular_function	ATP-dependent peptidase activity
n	0004252	molecular_function	serine-type endopeptidase activity
n	0005737	cellular_component	cytoplasm
n	0005829	cellular_component	cytosol
n	0005886	cellular_component	plasma membrane
n	0006508	biological_process	proteolysis
n	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
n	0008233	molecular_function	peptidase activity
n	0008236	molecular_function	serine-type peptidase activity
n	0009368	cellular_component	endopeptidase Clp complex
n	0016787	molecular_function	hydrolase activity
n	0051117	molecular_function	ATPase binding

Functional Information from PROSITE/UniProt

site_id	PS00381
Number of Residues	12
Details	CLP_PROTEASE_SER Endopeptidase Clp serine active site. TvcLGqAASAAA

Chain	Residue	Details
A	THR102-ALA113

---

site_id	PS00382
Number of Residues	14
Details	CLP_PROTEASE_HIS Endopeptidase Clp histidine active site. RyalPharILMHQP

Chain	Residue	Details
m	ARG112-PRO125
A	ARG124-PRO137

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	28
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_00444","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	28
Details	Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00444","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---