5E0J

1.20 A resolution structure of Norovirus 3CL protease in complex with a triazole-based macrocyclic (21-mer) inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue CL A 201

Chain	Residue
A	THR4
A	LEU5
A	ARG8
A	HOH455

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site_id	AC2
Number of Residues	3
Details	binding site for residue CL A 202

Chain	Residue
A	GLN51
A	HOH376
A	HOH461

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site_id	AC3
Number of Residues	3
Details	binding site for residue CL A 203

Chain	Residue
A	HOH430
A	GLY13
A	HOH377

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site_id	AC4
Number of Residues	19
Details	binding site for residue 5LJ A 204

Chain	Residue
A	HIS30
A	GLU54
A	MET107
A	ILE109
A	GLN110
A	SER118
A	LEU132
A	GLY137
A	CYS139
A	GLY148
A	HIS157
A	ALA158
A	ALA159
A	ALA160
A	VAL168
A	HOH302
A	HOH312
A	HOH395
A	HOH406

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Active site: {"description":"For 3CLpro activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00870","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16641296","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23365454","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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