5DYH
Ti(IV) bound human serum transferrin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006826 | biological_process | iron ion transport |
| A | 0006879 | biological_process | intracellular iron ion homeostasis |
| A | 0008199 | molecular_function | ferric iron binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0006826 | biological_process | iron ion transport |
| B | 0006879 | biological_process | intracellular iron ion homeostasis |
| B | 0008199 | molecular_function | ferric iron binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue CIT A 701 |
| Chain | Residue |
| A | TYR426 |
| A | ARG456 |
| A | THR457 |
| A | TYR517 |
| A | 4TI707 |
| A | CO3708 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue CIT A 702 |
| Chain | Residue |
| A | TYR188 |
| A | LYS206 |
| A | TYR95 |
| A | ARG124 |
| A | SER125 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue CIT A 703 |
| Chain | Residue |
| A | ARG456 |
| A | GLY516 |
| A | TYR517 |
| A | THR518 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue CIT A 704 |
| Chain | Residue |
| A | ARG124 |
| A | GLY187 |
| A | TYR188 |
| A | SER189 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue CIT A 705 |
| Chain | Residue |
| A | GLU338 |
| A | LYS599 |
| B | ARG602 |
| B | HIS606 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue CIT A 706 |
| Chain | Residue |
| A | HIS578 |
| A | ARG581 |
| A | GLU654 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue 4TI A 707 |
| Chain | Residue |
| A | TYR426 |
| A | TYR517 |
| A | CIT701 |
| A | CO3708 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue CO3 A 708 |
| Chain | Residue |
| A | TYR426 |
| A | THR452 |
| A | ARG456 |
| A | THR457 |
| A | ALA458 |
| A | GLY459 |
| A | TYR517 |
| A | CIT701 |
| A | 4TI707 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue CIT B 701 |
| Chain | Residue |
| B | TYR426 |
| B | ARG456 |
| B | THR457 |
| B | TYR517 |
| B | CIT702 |
| B | 4TI706 |
| B | CO3707 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue CIT B 702 |
| Chain | Residue |
| B | ARG456 |
| B | TYR515 |
| B | GLY516 |
| B | TYR517 |
| B | THR518 |
| B | CIT701 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue CIT B 703 |
| Chain | Residue |
| B | TYR95 |
| B | ARG124 |
| B | SER125 |
| B | TYR188 |
| B | LYS206 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue CIT B 704 |
| Chain | Residue |
| B | ARG124 |
| B | PHE186 |
| B | GLY187 |
| B | TYR188 |
| B | SER189 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue CIT B 705 |
| Chain | Residue |
| A | SER348 |
| A | HIS349 |
| A | HIS350 |
| B | SER348 |
| B | HIS349 |
| B | HIS350 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue 4TI B 706 |
| Chain | Residue |
| B | TYR426 |
| B | TYR517 |
| B | CIT701 |
| B | CO3707 |
| site_id | AD6 |
| Number of Residues | 9 |
| Details | binding site for residue CO3 B 707 |
| Chain | Residue |
| B | TYR426 |
| B | THR452 |
| B | ARG456 |
| B | THR457 |
| B | ALA458 |
| B | GLY459 |
| B | TYR517 |
| B | CIT701 |
| B | 4TI706 |
Functional Information from PROSITE/UniProt
| site_id | PS00205 |
| Number of Residues | 10 |
| Details | TRANSFERRIN_LIKE_1 Transferrin-like domain signature 1. YyAVAVVKKD |
| Chain | Residue | Details |
| A | TYR95-ASP104 |
| site_id | PS00206 |
| Number of Residues | 17 |
| Details | TRANSFERRIN_LIKE_2 Transferrin-like domain signature 2. YsGAFKCLkdgaGDVAF |
| Chain | Residue | Details |
| A | TYR188-PHE204 | |
| A | TYR517-PHE532 |
| site_id | PS00207 |
| Number of Residues | 31 |
| Details | TRANSFERRIN_LIKE_3 Transferrin-like domain signature 3. QYeLLClDntrkp...VdeykdChlAqvpsHtVV |
| Chain | Residue | Details |
| A | GLN222-VAL252 | |
| A | ASP558-VAL588 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 644 |
| Details | Domain: {"description":"Transferrin-like 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00741","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 644 |
| Details | Domain: {"description":"Transferrin-like 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00741","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22327295","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3V83","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00741","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22327295","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22343719","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31636418","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3V83","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VE1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SOY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SOZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00741","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Dimethylated arginine","evidences":[{"source":"UniProtKB","id":"P12346","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine; by FAM20C","evidences":[{"source":"PubMed","id":"26091039","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"O-linked (GalNAc...) serine","featureId":"CAR_000073"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","featureId":"CAR_000074","evidences":[{"source":"PubMed","id":"14760718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15084671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15536627","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19838169","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22327295","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31636418","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SOY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SOZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; atypical; partial","evidences":[{"source":"PubMed","id":"15536627","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","featureId":"CAR_000075","evidences":[{"source":"PubMed","id":"14760718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15084671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15536627","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16740002","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19838169","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22327295","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
