5DW5
Succinyl-CoA:acetate CoA-transferase (AarCH6) bound to the CoA analogue 3'-phosphoadenosine 5'-(O-(N-propylpantothenamide))pyrophosphate (MX)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003986 | molecular_function | acetyl-CoA hydrolase activity |
| A | 0006083 | biological_process | acetate metabolic process |
| A | 0006084 | biological_process | acetyl-CoA metabolic process |
| A | 0006085 | biological_process | acetyl-CoA biosynthetic process |
| A | 0008410 | molecular_function | CoA-transferase activity |
| A | 0008775 | molecular_function | acetate CoA-transferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019427 | biological_process | acetyl-CoA biosynthetic process from acetate |
| A | 0045733 | biological_process | acetate catabolic process |
| A | 1901289 | biological_process | succinyl-CoA catabolic process |
| B | 0003986 | molecular_function | acetyl-CoA hydrolase activity |
| B | 0006083 | biological_process | acetate metabolic process |
| B | 0006084 | biological_process | acetyl-CoA metabolic process |
| B | 0006085 | biological_process | acetyl-CoA biosynthetic process |
| B | 0008410 | molecular_function | CoA-transferase activity |
| B | 0008775 | molecular_function | acetate CoA-transferase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0019427 | biological_process | acetyl-CoA biosynthetic process from acetate |
| B | 0045733 | biological_process | acetate catabolic process |
| B | 1901289 | biological_process | succinyl-CoA catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 601 |
| Chain | Residue |
| A | ASN112 |
| A | ARG120 |
| A | ASN125 |
| B | ACT601 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 602 |
| Chain | Residue |
| A | VAL196 |
| A | ARG354 |
| A | HOH1101 |
| B | ARG354 |
| B | HOH996 |
| site_id | AC3 |
| Number of Residues | 30 |
| Details | binding site for residue 0T1 A 603 |
| Chain | Residue |
| A | GLN267 |
| A | GLU294 |
| A | ASN361 |
| A | GLY362 |
| A | MET363 |
| A | ILE364 |
| A | SER374 |
| A | ASN384 |
| A | GLY385 |
| A | ILE386 |
| A | GLY388 |
| A | SER389 |
| A | ALA407 |
| A | LYS408 |
| A | ILE412 |
| A | HOH710 |
| A | HOH717 |
| A | HOH737 |
| A | HOH750 |
| A | HOH781 |
| A | HOH782 |
| A | HOH812 |
| A | HOH819 |
| A | HOH831 |
| A | HOH876 |
| A | HOH895 |
| A | HOH947 |
| A | HOH948 |
| A | HOH994 |
| B | LYS240 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue ACT A 604 |
| Chain | Residue |
| A | GLY443 |
| A | LEU444 |
| B | PHE110 |
| B | ASN112 |
| B | TYR126 |
| B | CL602 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue IMD A 605 |
| Chain | Residue |
| A | THR487 |
| A | LEU490 |
| A | SER491 |
| A | HOH922 |
| B | LEU486 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue IMD A 606 |
| Chain | Residue |
| A | ALA419 |
| A | VAL422 |
| B | ALA419 |
| B | HOH1044 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue ACT B 601 |
| Chain | Residue |
| A | PHE110 |
| A | ASN112 |
| A | ASN125 |
| A | TYR126 |
| A | CL601 |
| B | GLY443 |
| B | LEU444 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 602 |
| Chain | Residue |
| A | ACT604 |
| B | ARG120 |
| B | ASN125 |
| site_id | AC9 |
| Number of Residues | 33 |
| Details | binding site for residue 0T1 B 603 |
| Chain | Residue |
| B | GLN267 |
| B | VAL270 |
| B | GLY271 |
| B | ASN272 |
| B | VAL273 |
| B | GLU294 |
| B | ASN361 |
| B | GLY362 |
| B | MET363 |
| B | ILE364 |
| B | ASN384 |
| B | GLY385 |
| B | ILE386 |
| B | GLY388 |
| B | SER389 |
| B | ALA407 |
| B | LYS408 |
| B | ILE412 |
| B | HOH717 |
| B | HOH729 |
| B | HOH733 |
| B | HOH747 |
| B | HOH754 |
| B | HOH762 |
| B | HOH784 |
| B | HOH826 |
| B | HOH843 |
| B | HOH866 |
| B | HOH876 |
| B | HOH945 |
| B | HOH952 |
| B | HOH988 |
| B | HOH1011 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue IMD B 604 |
| Chain | Residue |
| B | LEU490 |
| B | SER491 |
| B | GLN494 |
| B | HOH892 |
| A | LEU486 |
| B | THR487 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"5-glutamyl coenzyme A thioester intermediate","evidences":[{"source":"PubMed","id":"23030530","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23030530","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
