5DTR

Crystal structure of Dot1L in complex with inhibitor CPD5 [N-(2,6-dichlorophenyl)-4-methoxy-N-methylquinolin-6-amine]

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0031151	molecular_function	histone H3K79 methyltransferase activity
A	0051726	biological_process	regulation of cell cycle
B	0031151	molecular_function	histone H3K79 methyltransferase activity
B	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue 5F7 A 401

Chain	Residue
A	PRO130
A	VAL310
A	SER311
A	PHE131
A	SER140
A	LEU143
A	PHE239
A	ASN241
A	VAL267
A	SER268
A	SER269

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site_id	AC2
Number of Residues	14
Details	binding site for residue 5F7 B 401

Chain	Residue
B	PRO130
B	PHE131
B	THR139
B	SER140
B	LEU143
B	VAL144
B	PHE239
B	VAL240
B	ASN241
B	VAL267
B	SER268
B	SER269
B	VAL310
B	SER311

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12628190","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NW3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00902","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12628190","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NW3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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