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5DT2

Crystal structure of Dot1L in complex with inhibitor CPD11 [N4-methyl-N2-(2-methyl-1-(2-phenoxyphenyl)-1H-indol-6-yl)pyrimidine-2,4-diamine]

Functional Information from GO Data
ChainGOidnamespacecontents
A0031151molecular_functionhistone H3K79 methyltransferase activity
A0051726biological_processregulation of cell cycle
B0031151molecular_functionhistone H3K79 methyltransferase activity
B0051726biological_processregulation of cell cycle
Functional Information from PDB Data
site_idAC1
Number of Residues15
Detailsbinding site for residue 5EV A 401
ChainResidue
APHE131
APHE243
AVAL267
ASER268
ASER269
ASER311
ATYR312
ASER140
ALEU143
AMET147
AASP161
ASER164
AVAL169
AVAL240
AASN241

site_idAC2
Number of Residues2
Detailsbinding site for residue SO4 A 402
ChainResidue
ATHR100
AARG101

site_idAC3
Number of Residues2
Detailsbinding site for residue SO4 A 403
ChainResidue
AASN79
AARG80

site_idAC4
Number of Residues17
Detailsbinding site for residue 5EV B 401
ChainResidue
BPHE131
BSER140
BLEU143
BMET147
BASP161
BGLY163
BSER164
BVAL169
BPHE239
BVAL240
BASN241
BPHE243
BVAL267
BSER268
BSER269
BSER311
BTYR312

site_idAC5
Number of Residues4
Detailsbinding site for residue SO4 B 402
ChainResidue
AASP189
BTHR100
BARG101
BLYS212

site_idAC6
Number of Residues6
Detailsbinding site for residue SO4 B 403
ChainResidue
BARG8
BLYS10
BASN79
BARG80
BHOH532
BHOH558

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues28
DetailsBinding site: {}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246333

PDB entries from 2025-12-17

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