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5DSX

Crystal structure of Dot1L in complex with inhibitor CPD10 [6'-chloro-1,4-dimethyl-5'-(2-methyl-6-((4-(methylamino)pyrimidin-2-yl)amino)-1H-indol-1-yl)-[3,3'-bipyridin]-2(1H)-one]

Functional Information from GO Data
ChainGOidnamespacecontents
A0031151molecular_functionhistone H3K79 methyltransferase activity
A0051726biological_processregulation of cell cycle
B0031151molecular_functionhistone H3K79 methyltransferase activity
B0051726biological_processregulation of cell cycle
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue K A 1001
ChainResidue
ALYS52
ALEU53
AMET55
AASN57

site_idAC2
Number of Residues15
Detailsbinding site for residue 5EW A 1002
ChainResidue
AVAL169
AVAL240
AASN241
APHE243
AVAL267
ASER268
ASER269
AVAL310
ASER311
AHOH1128
APHE131
ASER140
AVAL144
AASP161
ASER164

site_idAC3
Number of Residues6
Detailsbinding site for residue K B 1001
ChainResidue
BLYS52
BLEU53
BMET55
BASN57
BHOH1175
BHOH1179

site_idAC4
Number of Residues16
Detailsbinding site for residue 5EW B 1002
ChainResidue
BPHE131
BSER140
BVAL144
BASP161
BSER164
BVAL169
BPHE239
BVAL240
BASN241
BPHE243
BVAL267
BSER268
BSER269
BVAL310
BSER311
BHOH1159

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues28
DetailsBinding site: {}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

239149

PDB entries from 2025-07-23

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