5DST
Crystal structure of human PRMT8 in complex with SAH
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
A | 0018216 | biological_process | peptidyl-arginine methylation |
B | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
B | 0018216 | biological_process | peptidyl-arginine methylation |
C | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
C | 0018216 | biological_process | peptidyl-arginine methylation |
D | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
D | 0018216 | biological_process | peptidyl-arginine methylation |
E | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
E | 0018216 | biological_process | peptidyl-arginine methylation |
F | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
F | 0018216 | biological_process | peptidyl-arginine methylation |
G | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
G | 0018216 | biological_process | peptidyl-arginine methylation |
H | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
H | 0018216 | biological_process | peptidyl-arginine methylation |
I | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
I | 0018216 | biological_process | peptidyl-arginine methylation |
J | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
J | 0018216 | biological_process | peptidyl-arginine methylation |
K | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
K | 0018216 | biological_process | peptidyl-arginine methylation |
L | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
L | 0018216 | biological_process | peptidyl-arginine methylation |
M | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
M | 0018216 | biological_process | peptidyl-arginine methylation |
N | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
N | 0018216 | biological_process | peptidyl-arginine methylation |
O | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
O | 0018216 | biological_process | peptidyl-arginine methylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 18 |
Details | binding site for residue SAH A 401 |
Chain | Residue |
A | TYR80 |
A | GLU141 |
A | CYS142 |
A | GLY167 |
A | LYS168 |
A | VAL169 |
A | GLU170 |
A | GLU185 |
A | MET196 |
A | THR199 |
A | HIS86 |
A | MET89 |
A | ARG95 |
A | GLY119 |
A | SER120 |
A | THR122 |
A | ILE124 |
A | LEU125 |
site_id | AC2 |
Number of Residues | 15 |
Details | binding site for residue SAH B 401 |
Chain | Residue |
B | TYR80 |
B | HIS86 |
B | MET89 |
B | ARG95 |
B | GLY119 |
B | SER120 |
B | ILE124 |
B | LEU125 |
B | GLU141 |
B | CYS142 |
B | VAL169 |
B | GLU170 |
B | GLU185 |
B | MET196 |
B | THR199 |
site_id | AC3 |
Number of Residues | 17 |
Details | binding site for residue SAH C 401 |
Chain | Residue |
C | TYR80 |
C | HIS86 |
C | MET89 |
C | ARG95 |
C | GLY119 |
C | SER120 |
C | THR122 |
C | ILE124 |
C | LEU125 |
C | GLU141 |
C | CYS142 |
C | GLY167 |
C | LYS168 |
C | VAL169 |
C | GLU170 |
C | MET196 |
C | THR199 |
site_id | AC4 |
Number of Residues | 18 |
Details | binding site for residue SAH D 401 |
Chain | Residue |
D | TYR80 |
D | HIS86 |
D | MET89 |
D | ARG95 |
D | GLY119 |
D | SER120 |
D | THR122 |
D | ILE124 |
D | LEU125 |
D | GLU141 |
D | CYS142 |
D | SER143 |
D | GLY167 |
D | LYS168 |
D | VAL169 |
D | GLU170 |
D | MET196 |
D | THR199 |
site_id | AC5 |
Number of Residues | 15 |
Details | binding site for residue SAH E 401 |
Chain | Residue |
E | TYR80 |
E | HIS86 |
E | MET89 |
E | ARG95 |
E | GLY119 |
E | SER120 |
E | THR122 |
E | ILE124 |
E | LEU125 |
E | GLU141 |
E | CYS142 |
E | VAL169 |
E | GLU170 |
E | MET196 |
E | THR199 |
site_id | AC6 |
Number of Residues | 17 |
Details | binding site for residue SAH F 401 |
Chain | Residue |
F | THR199 |
F | TYR80 |
F | HIS86 |
F | MET89 |
F | ARG95 |
F | GLY119 |
F | SER120 |
F | THR122 |
F | ILE124 |
F | LEU125 |
F | GLU141 |
F | CYS142 |
F | GLY167 |
F | VAL169 |
F | GLU170 |
F | GLU185 |
F | MET196 |
site_id | AC7 |
Number of Residues | 17 |
Details | binding site for residue SAH G 401 |
Chain | Residue |
G | TYR80 |
G | HIS86 |
G | ARG95 |
G | GLY119 |
G | SER120 |
G | THR122 |
G | ILE124 |
G | LEU125 |
G | GLU141 |
G | CYS142 |
G | GLY167 |
G | LYS168 |
G | VAL169 |
G | GLU170 |
G | GLU185 |
G | MET196 |
G | THR199 |
site_id | AC8 |
Number of Residues | 16 |
Details | binding site for residue SAH H 401 |
Chain | Residue |
H | TYR80 |
H | MET89 |
H | ARG95 |
H | GLY119 |
H | SER120 |
H | THR122 |
H | ILE124 |
H | LEU125 |
H | GLU141 |
H | CYS142 |
H | GLY167 |
H | LYS168 |
H | VAL169 |
H | GLU170 |
H | MET196 |
H | THR199 |
site_id | AC9 |
Number of Residues | 17 |
Details | binding site for residue SAH I 401 |
Chain | Residue |
I | TYR80 |
I | MET89 |
I | ARG95 |
I | GLY119 |
I | SER120 |
I | GLY121 |
I | THR122 |
I | ILE124 |
I | LEU125 |
I | GLU141 |
I | CYS142 |
I | GLY167 |
I | LYS168 |
I | VAL169 |
I | GLU170 |
I | MET196 |
I | THR199 |
site_id | AD1 |
Number of Residues | 16 |
Details | binding site for residue SAH J 401 |
Chain | Residue |
J | TYR80 |
J | MET89 |
J | ARG95 |
J | GLY119 |
J | SER120 |
J | THR122 |
J | ILE124 |
J | LEU125 |
J | GLU141 |
J | CYS142 |
J | GLY167 |
J | LYS168 |
J | VAL169 |
J | GLU170 |
J | MET196 |
J | THR199 |
site_id | AD2 |
Number of Residues | 16 |
Details | binding site for residue SAH K 401 |
Chain | Residue |
K | TYR80 |
K | HIS86 |
K | ARG95 |
K | GLY119 |
K | SER120 |
K | THR122 |
K | ILE124 |
K | LEU125 |
K | GLU141 |
K | CYS142 |
K | GLY167 |
K | LYS168 |
K | VAL169 |
K | GLU170 |
K | MET196 |
K | THR199 |
site_id | AD3 |
Number of Residues | 17 |
Details | binding site for residue SAH L 401 |
Chain | Residue |
L | TYR80 |
L | HIS86 |
L | MET89 |
L | ARG95 |
L | GLY119 |
L | SER120 |
L | THR122 |
L | ILE124 |
L | LEU125 |
L | GLU141 |
L | CYS142 |
L | GLY167 |
L | VAL169 |
L | GLU170 |
L | GLU185 |
L | MET196 |
L | THR199 |
site_id | AD4 |
Number of Residues | 17 |
Details | binding site for residue SAH M 401 |
Chain | Residue |
M | TYR80 |
M | HIS86 |
M | MET89 |
M | ARG95 |
M | GLY119 |
M | SER120 |
M | THR122 |
M | ILE124 |
M | LEU125 |
M | GLU141 |
M | CYS142 |
M | SER143 |
M | VAL169 |
M | GLU170 |
M | GLU185 |
M | MET196 |
M | THR199 |
site_id | AD5 |
Number of Residues | 14 |
Details | binding site for residue SAH N 401 |
Chain | Residue |
N | TYR80 |
N | HIS86 |
N | ARG95 |
N | GLY119 |
N | SER120 |
N | THR122 |
N | LEU125 |
N | GLU141 |
N | CYS142 |
N | GLY167 |
N | VAL169 |
N | GLU170 |
N | MET196 |
N | THR199 |
site_id | AD6 |
Number of Residues | 19 |
Details | binding site for residue SAH O 401 |
Chain | Residue |
O | TYR80 |
O | HIS86 |
O | MET89 |
O | ARG95 |
O | GLY119 |
O | SER120 |
O | GLY121 |
O | THR122 |
O | ILE124 |
O | LEU125 |
O | GLU141 |
O | CYS142 |
O | GLY167 |
O | LYS168 |
O | VAL169 |
O | GLU170 |
O | GLU185 |
O | MET196 |
O | THR199 |
Functional Information from PROSITE/UniProt
site_id | PS00329 |
Number of Residues | 14 |
Details | HSP70_2 Heat shock hsp70 proteins family signature 2. VLDVGSGTgilSMF |
Chain | Residue | Details |
A | VAL115-PHE128 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 30 |
Details | ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:Q63009 |
Chain | Residue | Details |
A | GLU185 | |
E | GLU194 | |
F | GLU185 | |
F | GLU194 | |
G | GLU185 | |
G | GLU194 | |
H | GLU185 | |
H | GLU194 | |
I | GLU185 | |
I | GLU194 | |
J | GLU185 | |
A | GLU194 | |
J | GLU194 | |
K | GLU185 | |
K | GLU194 | |
L | GLU185 | |
L | GLU194 | |
M | GLU185 | |
M | GLU194 | |
N | GLU185 | |
N | GLU194 | |
O | GLU185 | |
B | GLU185 | |
O | GLU194 | |
B | GLU194 | |
C | GLU185 | |
C | GLU194 | |
D | GLU185 | |
D | GLU194 | |
E | GLU185 |
site_id | SWS_FT_FI2 |
Number of Residues | 15 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q63009 |
Chain | Residue | Details |
A | HIS86 | |
J | HIS86 | |
K | HIS86 | |
L | HIS86 | |
M | HIS86 | |
N | HIS86 | |
O | HIS86 | |
B | HIS86 | |
C | HIS86 | |
D | HIS86 | |
E | HIS86 | |
F | HIS86 | |
G | HIS86 | |
H | HIS86 | |
I | HIS86 |
site_id | SWS_FT_FI3 |
Number of Residues | 30 |
Details | BINDING: BINDING => ECO:0000305|PubMed:26529540, ECO:0000305|PubMed:26876602, ECO:0007744|PDB:4X41, ECO:0007744|PDB:5DST |
Chain | Residue | Details |
A | ARG95 | |
E | GLU141 | |
F | ARG95 | |
F | GLU141 | |
G | ARG95 | |
G | GLU141 | |
H | ARG95 | |
H | GLU141 | |
I | ARG95 | |
I | GLU141 | |
J | ARG95 | |
A | GLU141 | |
J | GLU141 | |
K | ARG95 | |
K | GLU141 | |
L | ARG95 | |
L | GLU141 | |
M | ARG95 | |
M | GLU141 | |
N | ARG95 | |
N | GLU141 | |
O | ARG95 | |
B | ARG95 | |
O | GLU141 | |
B | GLU141 | |
C | ARG95 | |
C | GLU141 | |
D | ARG95 | |
D | GLU141 | |
E | ARG95 |
site_id | SWS_FT_FI4 |
Number of Residues | 30 |
Details | BINDING: BINDING => ECO:0000305|PubMed:26876602, ECO:0007744|PDB:5DST |
Chain | Residue | Details |
A | GLY119 | |
E | GLU170 | |
F | GLY119 | |
F | GLU170 | |
G | GLY119 | |
G | GLU170 | |
H | GLY119 | |
H | GLU170 | |
I | GLY119 | |
I | GLU170 | |
J | GLY119 | |
A | GLU170 | |
J | GLU170 | |
K | GLY119 | |
K | GLU170 | |
L | GLY119 | |
L | GLU170 | |
M | GLY119 | |
M | GLU170 | |
N | GLY119 | |
N | GLU170 | |
O | GLY119 | |
B | GLY119 | |
O | GLU170 | |
B | GLU170 | |
C | GLY119 | |
C | GLU170 | |
D | GLY119 | |
D | GLU170 | |
E | GLY119 |
site_id | SWS_FT_FI5 |
Number of Residues | 15 |
Details | MOD_RES: Asymmetric dimethylarginine; by autocatalysis => ECO:0000269|PubMed:17925405 |
Chain | Residue | Details |
A | ARG73 | |
J | ARG73 | |
K | ARG73 | |
L | ARG73 | |
M | ARG73 | |
N | ARG73 | |
O | ARG73 | |
B | ARG73 | |
C | ARG73 | |
D | ARG73 | |
E | ARG73 | |
F | ARG73 | |
G | ARG73 | |
H | ARG73 | |
I | ARG73 |