5DRR

Crystal structure of the Pseudomonas aeruginosa LpxC/LPC-058 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005737	cellular_component	cytoplasm
A	0006629	biological_process	lipid metabolic process
A	0009245	biological_process	lipid A biosynthetic process
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
A	0103117	molecular_function	UDP-3-O-acyl-N-acetylglucosamine deacetylase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 301

Chain	Residue
A	HIS78
A	HIS237
A	ASP241
A	5EN303

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 302

Chain	Residue
A	HIS162
A	GLU219
A	ASP277
A	ASP279

---

site_id	AC3
Number of Residues	21
Details	binding site for residue 5EN A 303

Chain	Residue
A	GLU77
A	HIS78
A	PHE112
A	GLN115
A	THR190
A	PHE191
A	ILE197
A	GLY209
A	SER210
A	VAL211
A	VAL216
A	HIS237
A	LYS238
A	ASP241
A	HIS264
A	ZN301
A	HOH405
A	HOH426
A	HOH493
A	HOH594
A	MET62

---

site_id	AC4
Number of Residues	9
Details	binding site for residue NO3 A 304

Chain	Residue
A	ILE158
A	ARG168
A	THR169
A	GLN170
A	ASP232
A	GLU233
A	PHE234
A	VAL235
A	HOH445

---

site_id	AC5
Number of Residues	4
Details	binding site for residue NO3 A 305

Chain	Residue
A	ARG168
A	VAL222
A	GLY227
A	LEU228

---

site_id	AC6
Number of Residues	5
Details	binding site for residue NO3 A 306

Chain	Residue
A	GLU184
A	TYR230
A	LYS236
A	NO3320
A	HOH410

---

site_id	AC7
Number of Residues	2
Details	binding site for residue NO3 A 307

Chain	Residue
A	SER295
A	TYR296

---

site_id	AC8
Number of Residues	5
Details	binding site for residue NO3 A 308

Chain	Residue
A	HIS19
A	MET62
A	LEU200
A	LEU205
A	ALA206

---

site_id	AC9
Number of Residues	5
Details	binding site for residue NO3 A 309

Chain	Residue
A	SER136
A	GLU138
A	ARG143
A	ASN220
A	HOH403

---

site_id	AD1
Number of Residues	5
Details	binding site for residue NO3 A 310

Chain	Residue
A	VAL137
A	GLU138
A	GLN269
A	HOH403
A	HOH420

---

site_id	AD2
Number of Residues	7
Details	binding site for residue NO3 A 311

Chain	Residue
A	PHE176
A	SER177
A	PRO293
A	ILE294
A	SER295
A	HOH513
A	HOH525

---

site_id	AD3
Number of Residues	4
Details	binding site for residue NO3 A 312

Chain	Residue
A	THR14
A	GLY15
A	VAL16
A	LYS23

---

site_id	AD4
Number of Residues	6
Details	binding site for residue NO3 A 313

Chain	Residue
A	LYS142
A	SER262
A	GLY263
A	ALA265
A	LEU266
A	HOH404

---

site_id	AD5
Number of Residues	8
Details	binding site for residue NO3 A 314

Chain	Residue
A	ARG189
A	SER202
A	GLN203
A	ASN204
A	ARG229
A	HOH429
A	HOH446
A	HOH533

---

site_id	AD6
Number of Residues	5
Details	binding site for residue NO3 A 315

Chain	Residue
A	ILE10
A	ARG12
A	ARG143
A	ARG258
A	PHE260

---

site_id	AD7
Number of Residues	6
Details	binding site for residue NO3 A 316

Chain	Residue
A	HOH541
A	ILE158
A	ASP159
A	PHE160
A	LYS261
A	HOH437

---

site_id	AD8
Number of Residues	8
Details	binding site for residue NO3 A 317

Chain	Residue
A	ARG12
A	THR14
A	ARG133
A	GLU134
A	PRO148
A	ARG195
A	HOH497
A	HOH516

---

site_id	AD9
Number of Residues	8
Details	binding site for residue NO3 A 318

Chain	Residue
A	TYR25
A	SER96
A	PRO148
A	PHE149
A	ASP150
A	HOH423
A	HOH454
A	HOH604

---

site_id	AE1
Number of Residues	4
Details	binding site for residue NO3 A 319

Chain	Residue
A	ARG166
A	GLN269
A	ARG272
A	THR273

---

site_id	AE2
Number of Residues	5
Details	binding site for residue NO3 A 320

Chain	Residue
A	TYR230
A	GLU231
A	ASP232
A	LYS236
A	NO3306

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"HAMAP-Rule","id":"MF_00388","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00388","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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