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5DRJ

Crystal Structure of the ER-alpha Ligand-binding Domain in complex with a dichloro-substituted, 3-methyl 2,5-diarylthiophene-core ligand 4,4'-(3-methylthiene-2,5-diyl)bis(3-chlorophenol)

Functional Information from PDB Data
site_idAC1
Number of Residues12
Detailsbinding site for residue 5EU A 601
ChainResidue
ALEU346
AGLY521
AHIS524
AHOH735
AALA350
AGLU353
ALEU387
AMET388
AARG394
AGLY420
AMET421
AILE424

site_idAC2
Number of Residues11
Detailsbinding site for residue 5EU B 601
ChainResidue
BLEU346
BALA350
BGLU353
BMET388
BARG394
BGLY420
BMET421
BILE424
BGLY521
BHIS524
BHOH728

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
CSER699
DSER699
AHIS524
BGLU353
BARG394
BHIS524

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by Tyr-kinases => ECO:0000269|PubMed:7539106
ChainResidueDetails
ASER537
BSER537

site_idSWS_FT_FI3
Number of Residues2
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250
ChainResidueDetails
ACYS447
BCYS447

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PDB entries from 2024-10-02

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