5DQT

Crystal Structure of Cas-DNA-22 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0004518	molecular_function	nuclease activity
A	0004519	molecular_function	endonuclease activity
A	0004520	molecular_function	DNA endonuclease activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0006281	biological_process	DNA repair
A	0006974	biological_process	DNA damage response
A	0008821	molecular_function	crossover junction DNA endonuclease activity
A	0016787	molecular_function	hydrolase activity
A	0017108	molecular_function	5'-flap endonuclease activity
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0043571	biological_process	maintenance of CRISPR repeat elements
A	0046872	molecular_function	metal ion binding
A	0051607	biological_process	defense response to virus
A	0099048	biological_process	CRISPR-cas system
B	0003676	molecular_function	nucleic acid binding
B	0003677	molecular_function	DNA binding
B	0004518	molecular_function	nuclease activity
B	0004519	molecular_function	endonuclease activity
B	0004520	molecular_function	DNA endonuclease activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0006281	biological_process	DNA repair
B	0006974	biological_process	DNA damage response
B	0008821	molecular_function	crossover junction DNA endonuclease activity
B	0016787	molecular_function	hydrolase activity
B	0017108	molecular_function	5'-flap endonuclease activity
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0043571	biological_process	maintenance of CRISPR repeat elements
B	0046872	molecular_function	metal ion binding
B	0051607	biological_process	defense response to virus
B	0099048	biological_process	CRISPR-cas system
C	0003676	molecular_function	nucleic acid binding
C	0003677	molecular_function	DNA binding
C	0004518	molecular_function	nuclease activity
C	0004519	molecular_function	endonuclease activity
C	0004520	molecular_function	DNA endonuclease activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0006281	biological_process	DNA repair
C	0006974	biological_process	DNA damage response
C	0008821	molecular_function	crossover junction DNA endonuclease activity
C	0016787	molecular_function	hydrolase activity
C	0017108	molecular_function	5'-flap endonuclease activity
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0043571	biological_process	maintenance of CRISPR repeat elements
C	0046872	molecular_function	metal ion binding
C	0051607	biological_process	defense response to virus
C	0099048	biological_process	CRISPR-cas system
D	0003676	molecular_function	nucleic acid binding
D	0003677	molecular_function	DNA binding
D	0004518	molecular_function	nuclease activity
D	0004519	molecular_function	endonuclease activity
D	0004520	molecular_function	DNA endonuclease activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0006281	biological_process	DNA repair
D	0006974	biological_process	DNA damage response
D	0008821	molecular_function	crossover junction DNA endonuclease activity
D	0016787	molecular_function	hydrolase activity
D	0017108	molecular_function	5'-flap endonuclease activity
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0043571	biological_process	maintenance of CRISPR repeat elements
D	0046872	molecular_function	metal ion binding
D	0051607	biological_process	defense response to virus
D	0099048	biological_process	CRISPR-cas system
E	0003677	molecular_function	DNA binding
E	0004518	molecular_function	nuclease activity
E	0004519	molecular_function	endonuclease activity
E	0005515	molecular_function	protein binding
E	0016787	molecular_function	hydrolase activity
E	0043571	biological_process	maintenance of CRISPR repeat elements
E	0051607	biological_process	defense response to virus
E	0099048	biological_process	CRISPR-cas system
F	0003677	molecular_function	DNA binding
F	0004518	molecular_function	nuclease activity
F	0004519	molecular_function	endonuclease activity
F	0005515	molecular_function	protein binding
F	0016787	molecular_function	hydrolase activity
F	0043571	biological_process	maintenance of CRISPR repeat elements
F	0051607	biological_process	defense response to virus
F	0099048	biological_process	CRISPR-cas system
I	0003676	molecular_function	nucleic acid binding
I	0003677	molecular_function	DNA binding
I	0004518	molecular_function	nuclease activity
I	0004519	molecular_function	endonuclease activity
I	0004520	molecular_function	DNA endonuclease activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0006281	biological_process	DNA repair
I	0006974	biological_process	DNA damage response
I	0008821	molecular_function	crossover junction DNA endonuclease activity
I	0016787	molecular_function	hydrolase activity
I	0017108	molecular_function	5'-flap endonuclease activity
I	0042802	molecular_function	identical protein binding
I	0042803	molecular_function	protein homodimerization activity
I	0043571	biological_process	maintenance of CRISPR repeat elements
I	0046872	molecular_function	metal ion binding
I	0051607	biological_process	defense response to virus
I	0099048	biological_process	CRISPR-cas system
J	0003676	molecular_function	nucleic acid binding
J	0003677	molecular_function	DNA binding
J	0004518	molecular_function	nuclease activity
J	0004519	molecular_function	endonuclease activity
J	0004520	molecular_function	DNA endonuclease activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0006281	biological_process	DNA repair
J	0006974	biological_process	DNA damage response
J	0008821	molecular_function	crossover junction DNA endonuclease activity
J	0016787	molecular_function	hydrolase activity
J	0017108	molecular_function	5'-flap endonuclease activity
J	0042802	molecular_function	identical protein binding
J	0042803	molecular_function	protein homodimerization activity
J	0043571	biological_process	maintenance of CRISPR repeat elements
J	0046872	molecular_function	metal ion binding
J	0051607	biological_process	defense response to virus
J	0099048	biological_process	CRISPR-cas system
K	0003676	molecular_function	nucleic acid binding
K	0003677	molecular_function	DNA binding
K	0004518	molecular_function	nuclease activity
K	0004519	molecular_function	endonuclease activity
K	0004520	molecular_function	DNA endonuclease activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0006281	biological_process	DNA repair
K	0006974	biological_process	DNA damage response
K	0008821	molecular_function	crossover junction DNA endonuclease activity
K	0016787	molecular_function	hydrolase activity
K	0017108	molecular_function	5'-flap endonuclease activity
K	0042802	molecular_function	identical protein binding
K	0042803	molecular_function	protein homodimerization activity
K	0043571	biological_process	maintenance of CRISPR repeat elements
K	0046872	molecular_function	metal ion binding
K	0051607	biological_process	defense response to virus
K	0099048	biological_process	CRISPR-cas system
L	0003676	molecular_function	nucleic acid binding
L	0003677	molecular_function	DNA binding
L	0004518	molecular_function	nuclease activity
L	0004519	molecular_function	endonuclease activity
L	0004520	molecular_function	DNA endonuclease activity
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0006281	biological_process	DNA repair
L	0006974	biological_process	DNA damage response
L	0008821	molecular_function	crossover junction DNA endonuclease activity
L	0016787	molecular_function	hydrolase activity
L	0017108	molecular_function	5'-flap endonuclease activity
L	0042802	molecular_function	identical protein binding
L	0042803	molecular_function	protein homodimerization activity
L	0043571	biological_process	maintenance of CRISPR repeat elements
L	0046872	molecular_function	metal ion binding
L	0051607	biological_process	defense response to virus
L	0099048	biological_process	CRISPR-cas system
M	0003677	molecular_function	DNA binding
M	0004518	molecular_function	nuclease activity
M	0004519	molecular_function	endonuclease activity
M	0005515	molecular_function	protein binding
M	0016787	molecular_function	hydrolase activity
M	0043571	biological_process	maintenance of CRISPR repeat elements
M	0051607	biological_process	defense response to virus
M	0099048	biological_process	CRISPR-cas system
N	0003677	molecular_function	DNA binding
N	0004518	molecular_function	nuclease activity
N	0004519	molecular_function	endonuclease activity
N	0005515	molecular_function	protein binding
N	0016787	molecular_function	hydrolase activity
N	0043571	biological_process	maintenance of CRISPR repeat elements
N	0051607	biological_process	defense response to virus
N	0099048	biological_process	CRISPR-cas system

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26503043","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5DS5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26503043","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1274
Details	Region: {"description":"Sufficient for cleavage of ssRNA, ssDNA and Holliday junction DNA"}

Chain

Residue

Details

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