5DQG

Crystal Structure of Human DNA Polymerase Eta Inserting dAMPNPP Opposite O4-Ethylthymidine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003684	molecular_function	damaged DNA binding
A	0006281	biological_process	DNA repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	binding site for residue DZ4 A 501

Chain	Residue
A	ASP13
A	ARG55
A	ARG61
A	ASP115
A	LYS231
A	MG502
A	MG503
A	HOH618
A	HOH640
A	HOH690
A	HOH698
A	MET14
A	HOH702
P	DT8
T	DT3
T	5EJ4
A	ASP15
A	CYS16
A	PHE17
A	PHE18
A	ILE48
A	ALA49
A	TYR52

---

site_id	AC2
Number of Residues	5
Details	binding site for residue MG A 502

Chain	Residue
A	ASP13
A	MET14
A	ASP115
A	DZ4501
A	MG503

---

site_id	AC3
Number of Residues	7
Details	binding site for residue MG A 503

Chain	Residue
A	ASP13
A	ASP115
A	GLU116
A	DZ4501
A	MG502
A	HOH690
P	DT8

---

site_id	AC4
Number of Residues	9
Details	binding site for residue GOL A 504

Chain	Residue
A	ARG24
A	PRO244
A	PHE247
A	SER248
A	GLY276
A	GLU277
A	HOH610
A	HOH645
A	HOH683

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27284197","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5KFO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27284197","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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