5DOT
Crystal Structure of Human Carbamoyl phosphate synthetase I (CPS1), apo form
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000050 | biological_process | urea cycle |
A | 0001889 | biological_process | liver development |
A | 0004087 | molecular_function | carbamoyl-phosphate synthase (ammonia) activity |
A | 0004088 | molecular_function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
A | 0004175 | molecular_function | endopeptidase activity |
A | 0005509 | molecular_function | calcium ion binding |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005543 | molecular_function | phospholipid binding |
A | 0005634 | cellular_component | nucleus |
A | 0005730 | cellular_component | nucleolus |
A | 0005737 | cellular_component | cytoplasm |
A | 0005739 | cellular_component | mitochondrion |
A | 0005743 | cellular_component | mitochondrial inner membrane |
A | 0005759 | cellular_component | mitochondrial matrix |
A | 0005886 | cellular_component | plasma membrane |
A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
A | 0006541 | biological_process | glutamine metabolic process |
A | 0007494 | biological_process | midgut development |
A | 0009410 | biological_process | response to xenobiotic stimulus |
A | 0009636 | biological_process | response to toxic substance |
A | 0010043 | biological_process | response to zinc ion |
A | 0014075 | biological_process | response to amine |
A | 0016595 | molecular_function | glutamate binding |
A | 0016874 | molecular_function | ligase activity |
A | 0019240 | biological_process | citrulline biosynthetic process |
A | 0019433 | biological_process | triglyceride catabolic process |
A | 0019637 | biological_process | organophosphate metabolic process |
A | 0030955 | molecular_function | potassium ion binding |
A | 0032094 | biological_process | response to food |
A | 0032496 | biological_process | response to lipopolysaccharide |
A | 0032991 | cellular_component | protein-containing complex |
A | 0033762 | biological_process | response to glucagon |
A | 0034201 | biological_process | response to oleic acid |
A | 0036094 | molecular_function | small molecule binding |
A | 0042311 | biological_process | vasodilation |
A | 0042594 | biological_process | response to starvation |
A | 0042645 | cellular_component | mitochondrial nucleoid |
A | 0043200 | biological_process | response to amino acid |
A | 0044344 | biological_process | cellular response to fibroblast growth factor stimulus |
A | 0044877 | molecular_function | protein-containing complex binding |
A | 0046209 | biological_process | nitric oxide metabolic process |
A | 0046872 | molecular_function | metal ion binding |
A | 0048545 | biological_process | response to steroid hormone |
A | 0050667 | biological_process | homocysteine metabolic process |
A | 0051384 | biological_process | response to glucocorticoid |
A | 0051591 | biological_process | response to cAMP |
A | 0055081 | biological_process | monoatomic anion homeostasis |
A | 0060416 | biological_process | response to growth hormone |
A | 0070365 | biological_process | hepatocyte differentiation |
A | 0070409 | biological_process | carbamoyl phosphate biosynthetic process |
A | 0071242 | biological_process | cellular response to ammonium ion |
A | 0071320 | biological_process | cellular response to cAMP |
A | 0071377 | biological_process | cellular response to glucagon stimulus |
A | 0071400 | biological_process | cellular response to oleic acid |
A | 0071548 | biological_process | response to dexamethasone |
A | 0072341 | molecular_function | modified amino acid binding |
B | 0000050 | biological_process | urea cycle |
B | 0001889 | biological_process | liver development |
B | 0004087 | molecular_function | carbamoyl-phosphate synthase (ammonia) activity |
B | 0004088 | molecular_function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
B | 0004175 | molecular_function | endopeptidase activity |
B | 0005509 | molecular_function | calcium ion binding |
B | 0005515 | molecular_function | protein binding |
B | 0005524 | molecular_function | ATP binding |
B | 0005543 | molecular_function | phospholipid binding |
B | 0005634 | cellular_component | nucleus |
B | 0005730 | cellular_component | nucleolus |
B | 0005737 | cellular_component | cytoplasm |
B | 0005739 | cellular_component | mitochondrion |
B | 0005743 | cellular_component | mitochondrial inner membrane |
B | 0005759 | cellular_component | mitochondrial matrix |
B | 0005886 | cellular_component | plasma membrane |
B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
B | 0006541 | biological_process | glutamine metabolic process |
B | 0007494 | biological_process | midgut development |
B | 0009410 | biological_process | response to xenobiotic stimulus |
B | 0009636 | biological_process | response to toxic substance |
B | 0010043 | biological_process | response to zinc ion |
B | 0014075 | biological_process | response to amine |
B | 0016595 | molecular_function | glutamate binding |
B | 0016874 | molecular_function | ligase activity |
B | 0019240 | biological_process | citrulline biosynthetic process |
B | 0019433 | biological_process | triglyceride catabolic process |
B | 0019637 | biological_process | organophosphate metabolic process |
B | 0030955 | molecular_function | potassium ion binding |
B | 0032094 | biological_process | response to food |
B | 0032496 | biological_process | response to lipopolysaccharide |
B | 0032991 | cellular_component | protein-containing complex |
B | 0033762 | biological_process | response to glucagon |
B | 0034201 | biological_process | response to oleic acid |
B | 0036094 | molecular_function | small molecule binding |
B | 0042311 | biological_process | vasodilation |
B | 0042594 | biological_process | response to starvation |
B | 0042645 | cellular_component | mitochondrial nucleoid |
B | 0043200 | biological_process | response to amino acid |
B | 0044344 | biological_process | cellular response to fibroblast growth factor stimulus |
B | 0044877 | molecular_function | protein-containing complex binding |
B | 0046209 | biological_process | nitric oxide metabolic process |
B | 0046872 | molecular_function | metal ion binding |
B | 0048545 | biological_process | response to steroid hormone |
B | 0050667 | biological_process | homocysteine metabolic process |
B | 0051384 | biological_process | response to glucocorticoid |
B | 0051591 | biological_process | response to cAMP |
B | 0055081 | biological_process | monoatomic anion homeostasis |
B | 0060416 | biological_process | response to growth hormone |
B | 0070365 | biological_process | hepatocyte differentiation |
B | 0070409 | biological_process | carbamoyl phosphate biosynthetic process |
B | 0071242 | biological_process | cellular response to ammonium ion |
B | 0071320 | biological_process | cellular response to cAMP |
B | 0071377 | biological_process | cellular response to glucagon stimulus |
B | 0071400 | biological_process | cellular response to oleic acid |
B | 0071548 | biological_process | response to dexamethasone |
B | 0072341 | molecular_function | modified amino acid binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | binding site for residue NI A 1601 |
Chain | Residue |
A | ASN315 |
A | GLN335 |
A | HIS337 |
A | GLU362 |
A | HOH1847 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue EDO A 1602 |
Chain | Residue |
A | HOH2016 |
A | LYS905 |
A | TRP940 |
A | GLY964 |
A | GLN965 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue EDO A 1603 |
Chain | Residue |
A | ARG814 |
A | SER913 |
A | GLU1034 |
A | SER1036 |
A | GLU1038 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue EDO A 1604 |
Chain | Residue |
A | LEU134 |
A | ASP135 |
A | GLY163 |
A | ARG906 |
A | GLU909 |
A | ASN963 |
site_id | AC5 |
Number of Residues | 5 |
Details | binding site for residue GOL A 1605 |
Chain | Residue |
A | SER863 |
A | LEU864 |
A | ASP865 |
A | TYR879 |
A | HOH1758 |
site_id | AC6 |
Number of Residues | 4 |
Details | binding site for residue EDO A 1606 |
Chain | Residue |
A | PRO87 |
A | SER123 |
A | ASN124 |
A | ILE227 |
site_id | AC7 |
Number of Residues | 4 |
Details | binding site for residue GOL A 1607 |
Chain | Residue |
A | PRO1299 |
A | ILE1300 |
A | ILE1301 |
B | GLU1221 |
site_id | AC8 |
Number of Residues | 5 |
Details | binding site for residue NI B 1601 |
Chain | Residue |
B | ASN315 |
B | GLN335 |
B | HIS337 |
B | GLU362 |
B | HOH1819 |
site_id | AC9 |
Number of Residues | 7 |
Details | binding site for residue EDO B 1602 |
Chain | Residue |
B | ARG814 |
B | SER913 |
B | GLU1034 |
B | SER1036 |
B | GLU1038 |
B | ARG1039 |
B | HOH2049 |
site_id | AD1 |
Number of Residues | 4 |
Details | binding site for residue GOL B 1603 |
Chain | Residue |
B | LEU864 |
B | ASP865 |
B | LYS875 |
B | TYR879 |
site_id | AD2 |
Number of Residues | 7 |
Details | binding site for residue GOL B 1604 |
Chain | Residue |
A | ASP1088 |
A | SER1090 |
B | LYS892 |
B | LEU894 |
B | CYS920 |
B | LEU921 |
B | HOH1972 |
Functional Information from PROSITE/UniProt
site_id | PS00866 |
Number of Residues | 15 |
Details | CPSASE_1 Carbamoyl-phosphate synthase subdomain signature 1. YPVMIRSAyalGGlG |
Chain | Residue | Details |
A | TYR582-GLY596 | |
A | TYR1124-ALA1138 |
site_id | PS00867 |
Number of Residues | 8 |
Details | CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. IIEVNARL |
Chain | Residue | Details |
A | ILE712-LEU719 | |
A | VAL1253-ALA1260 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000305 |
Chain | Residue | Details |
A | THR1391 | |
B | ASN1437 | |
B | ASN1440 | |
B | ASN1449 | |
A | THR1394 | |
A | TRP1410 | |
A | ASN1437 | |
A | ASN1440 | |
A | ASN1449 | |
B | THR1391 | |
B | THR1394 | |
B | TRP1410 |
site_id | SWS_FT_FI2 |
Number of Residues | 78 |
Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q8C196 |
Chain | Residue | Details |
A | LYS55 | |
A | LYS412 | |
A | LYS458 | |
A | LYS522 | |
A | LYS527 | |
A | LYS553 | |
A | LYS560 | |
A | LYS575 | |
A | LYS612 | |
A | LYS751 | |
A | LYS757 | |
A | LYS57 | |
A | LYS793 | |
A | LYS831 | |
A | LYS875 | |
A | LYS889 | |
A | LYS892 | |
A | LYS915 | |
A | LYS919 | |
A | LYS1074 | |
A | LYS1100 | |
A | LYS1168 | |
A | LYS119 | |
A | LYS1183 | |
A | LYS1232 | |
A | LYS1269 | |
A | LYS1291 | |
A | LYS1356 | |
A | LYS1360 | |
A | LYS1444 | |
A | LYS1471 | |
A | LYS1479 | |
A | LYS1486 | |
A | LYS157 | |
B | LYS55 | |
B | LYS57 | |
B | LYS119 | |
B | LYS157 | |
B | LYS207 | |
B | LYS214 | |
B | LYS287 | |
B | LYS307 | |
B | LYS402 | |
B | LYS412 | |
A | LYS207 | |
B | LYS458 | |
B | LYS522 | |
B | LYS527 | |
B | LYS553 | |
B | LYS560 | |
B | LYS575 | |
B | LYS612 | |
B | LYS751 | |
B | LYS757 | |
B | LYS793 | |
A | LYS214 | |
B | LYS831 | |
B | LYS875 | |
B | LYS889 | |
B | LYS892 | |
B | LYS915 | |
B | LYS919 | |
B | LYS1074 | |
B | LYS1100 | |
B | LYS1168 | |
B | LYS1183 | |
A | LYS287 | |
B | LYS1232 | |
B | LYS1269 | |
B | LYS1291 | |
B | LYS1356 | |
B | LYS1360 | |
B | LYS1444 | |
B | LYS1471 | |
B | LYS1479 | |
B | LYS1486 | |
A | LYS307 | |
A | LYS402 |
site_id | SWS_FT_FI3 |
Number of Residues | 12 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | SER148 | |
B | SER1203 | |
B | SER1419 | |
B | SER1431 | |
A | SER569 | |
A | SER835 | |
A | SER1203 | |
A | SER1419 | |
A | SER1431 | |
B | SER148 | |
B | SER569 | |
B | SER835 |
site_id | SWS_FT_FI4 |
Number of Residues | 26 |
Details | MOD_RES: N6-glutaryllysine; alternate => ECO:0000269|PubMed:24703693 |
Chain | Residue | Details |
A | LYS171 | |
A | LYS811 | |
A | LYS841 | |
A | LYS856 | |
A | LYS908 | |
B | LYS171 | |
B | LYS210 | |
B | LYS219 | |
B | LYS228 | |
B | LYS280 | |
B | LYS310 | |
A | LYS210 | |
B | LYS453 | |
B | LYS532 | |
B | LYS772 | |
B | LYS811 | |
B | LYS841 | |
B | LYS856 | |
B | LYS908 | |
A | LYS219 | |
A | LYS228 | |
A | LYS280 | |
A | LYS310 | |
A | LYS453 | |
A | LYS532 | |
A | LYS772 |
site_id | SWS_FT_FI5 |
Number of Residues | 14 |
Details | MOD_RES: N6-glutaryllysine => ECO:0000269|PubMed:24703693 |
Chain | Residue | Details |
A | LYS176 | |
B | LYS728 | |
B | LYS869 | |
B | LYS905 | |
B | LYS1150 | |
B | LYS1224 | |
A | LYS237 | |
A | LYS728 | |
A | LYS869 | |
A | LYS905 | |
A | LYS1150 | |
A | LYS1224 | |
B | LYS176 | |
B | LYS237 |
site_id | SWS_FT_FI6 |
Number of Residues | 10 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q8C196 |
Chain | Residue | Details |
A | LYS182 | |
B | LYS1222 | |
A | LYS197 | |
A | LYS630 | |
A | LYS935 | |
A | LYS1222 | |
B | LYS182 | |
B | LYS197 | |
B | LYS630 | |
B | LYS935 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q8C196 |
Chain | Residue | Details |
A | LYS400 | |
A | LYS1149 | |
B | LYS400 | |
B | LYS1149 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine; alternate => ECO:0000250|UniProtKB:Q8C196 |
Chain | Residue | Details |
A | SER537 | |
B | SER537 |
site_id | SWS_FT_FI9 |
Number of Residues | 10 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P07756 |
Chain | Residue | Details |
A | SER540 | |
B | SER1093 | |
A | SER896 | |
A | SER898 | |
A | SER1090 | |
A | SER1093 | |
B | SER540 | |
B | SER896 | |
B | SER898 | |
B | SER1090 |
site_id | SWS_FT_FI10 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER1036 | |
B | SER1036 |
site_id | SWS_FT_FI11 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | SER1079 | |
B | SER1079 |
site_id | SWS_FT_FI12 |
Number of Residues | 2 |
Details | CARBOHYD: O-linked (GlcNAc) serine; alternate => ECO:0000250 |
Chain | Residue | Details |
A | SER537 | |
B | SER537 |
site_id | SWS_FT_FI13 |
Number of Residues | 2 |
Details | CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250 |
Chain | Residue | Details |
A | SER1331 | |
B | SER1331 |
site_id | SWS_FT_FI14 |
Number of Residues | 2 |
Details | CARBOHYD: O-linked (GlcNAc) threonine => ECO:0000250 |
Chain | Residue | Details |
A | THR1332 | |
B | THR1332 |