5DL1
ClpP from Staphylococcus aureus in complex with AV145
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004176 | molecular_function | ATP-dependent peptidase activity |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006508 | biological_process | proteolysis |
| A | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| A | 0009368 | cellular_component | endopeptidase Clp complex |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0051117 | molecular_function | ATPase binding |
| B | 0004176 | molecular_function | ATP-dependent peptidase activity |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006508 | biological_process | proteolysis |
| B | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| B | 0009368 | cellular_component | endopeptidase Clp complex |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0051117 | molecular_function | ATPase binding |
| C | 0004176 | molecular_function | ATP-dependent peptidase activity |
| C | 0004252 | molecular_function | serine-type endopeptidase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006508 | biological_process | proteolysis |
| C | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| C | 0009368 | cellular_component | endopeptidase Clp complex |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0051117 | molecular_function | ATPase binding |
| D | 0004176 | molecular_function | ATP-dependent peptidase activity |
| D | 0004252 | molecular_function | serine-type endopeptidase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006508 | biological_process | proteolysis |
| D | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| D | 0009368 | cellular_component | endopeptidase Clp complex |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0051117 | molecular_function | ATPase binding |
| E | 0004176 | molecular_function | ATP-dependent peptidase activity |
| E | 0004252 | molecular_function | serine-type endopeptidase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006508 | biological_process | proteolysis |
| E | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| E | 0009368 | cellular_component | endopeptidase Clp complex |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0051117 | molecular_function | ATPase binding |
| F | 0004176 | molecular_function | ATP-dependent peptidase activity |
| F | 0004252 | molecular_function | serine-type endopeptidase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006508 | biological_process | proteolysis |
| F | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| F | 0009368 | cellular_component | endopeptidase Clp complex |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0051117 | molecular_function | ATPase binding |
| G | 0004176 | molecular_function | ATP-dependent peptidase activity |
| G | 0004252 | molecular_function | serine-type endopeptidase activity |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0006508 | biological_process | proteolysis |
| G | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| G | 0009368 | cellular_component | endopeptidase Clp complex |
| G | 0042802 | molecular_function | identical protein binding |
| G | 0051117 | molecular_function | ATPase binding |
| H | 0004176 | molecular_function | ATP-dependent peptidase activity |
| H | 0004252 | molecular_function | serine-type endopeptidase activity |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0006508 | biological_process | proteolysis |
| H | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| H | 0009368 | cellular_component | endopeptidase Clp complex |
| H | 0042802 | molecular_function | identical protein binding |
| H | 0051117 | molecular_function | ATPase binding |
| I | 0004176 | molecular_function | ATP-dependent peptidase activity |
| I | 0004252 | molecular_function | serine-type endopeptidase activity |
| I | 0005737 | cellular_component | cytoplasm |
| I | 0006508 | biological_process | proteolysis |
| I | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| I | 0009368 | cellular_component | endopeptidase Clp complex |
| I | 0042802 | molecular_function | identical protein binding |
| I | 0051117 | molecular_function | ATPase binding |
| J | 0004176 | molecular_function | ATP-dependent peptidase activity |
| J | 0004252 | molecular_function | serine-type endopeptidase activity |
| J | 0005737 | cellular_component | cytoplasm |
| J | 0006508 | biological_process | proteolysis |
| J | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| J | 0009368 | cellular_component | endopeptidase Clp complex |
| J | 0042802 | molecular_function | identical protein binding |
| J | 0051117 | molecular_function | ATPase binding |
| K | 0004176 | molecular_function | ATP-dependent peptidase activity |
| K | 0004252 | molecular_function | serine-type endopeptidase activity |
| K | 0005737 | cellular_component | cytoplasm |
| K | 0006508 | biological_process | proteolysis |
| K | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| K | 0009368 | cellular_component | endopeptidase Clp complex |
| K | 0042802 | molecular_function | identical protein binding |
| K | 0051117 | molecular_function | ATPase binding |
| L | 0004176 | molecular_function | ATP-dependent peptidase activity |
| L | 0004252 | molecular_function | serine-type endopeptidase activity |
| L | 0005737 | cellular_component | cytoplasm |
| L | 0006508 | biological_process | proteolysis |
| L | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| L | 0009368 | cellular_component | endopeptidase Clp complex |
| L | 0042802 | molecular_function | identical protein binding |
| L | 0051117 | molecular_function | ATPase binding |
| M | 0004176 | molecular_function | ATP-dependent peptidase activity |
| M | 0004252 | molecular_function | serine-type endopeptidase activity |
| M | 0005737 | cellular_component | cytoplasm |
| M | 0006508 | biological_process | proteolysis |
| M | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| M | 0009368 | cellular_component | endopeptidase Clp complex |
| M | 0042802 | molecular_function | identical protein binding |
| M | 0051117 | molecular_function | ATPase binding |
| N | 0004176 | molecular_function | ATP-dependent peptidase activity |
| N | 0004252 | molecular_function | serine-type endopeptidase activity |
| N | 0005737 | cellular_component | cytoplasm |
| N | 0006508 | biological_process | proteolysis |
| N | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| N | 0009368 | cellular_component | endopeptidase Clp complex |
| N | 0042802 | molecular_function | identical protein binding |
| N | 0051117 | molecular_function | ATPase binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue 5C2 A 201 |
| Chain | Residue |
| A | SER98 |
| A | ARG147 |
| A | LEU150 |
| A | ASN151 |
| A | THR169 |
| N | ILE136 |
| A | SER101 |
| A | ILE122 |
| A | HIS123 |
| A | GLN124 |
| A | PRO125 |
| A | LEU126 |
| A | GLN132 |
| A | ILE143 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | binding site for residue 5C2 B 201 |
| Chain | Residue |
| B | VAL71 |
| B | SER98 |
| B | SER101 |
| B | HIS123 |
| B | GLN124 |
| B | PRO125 |
| B | LEU126 |
| B | GLN132 |
| B | ILE143 |
| B | ARG147 |
| B | LEU150 |
| B | ASN151 |
| B | LEU154 |
| B | THR169 |
| K | ILE136 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | binding site for residue 5C2 C 201 |
| Chain | Residue |
| C | VAL71 |
| C | SER98 |
| C | SER101 |
| C | HIS123 |
| C | GLN124 |
| C | PRO125 |
| C | GLY127 |
| C | GLY128 |
| C | GLN132 |
| C | HIS142 |
| C | ILE143 |
| C | THR146 |
| C | ARG147 |
| C | LEU150 |
| C | THR169 |
| J | ILE136 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | binding site for residue 5C2 D 201 |
| Chain | Residue |
| D | VAL71 |
| D | SER98 |
| D | SER101 |
| D | GLN124 |
| D | PRO125 |
| D | LEU126 |
| D | GLN132 |
| D | HIS142 |
| D | THR146 |
| D | ARG147 |
| D | LEU150 |
| D | ASN151 |
| D | LEU154 |
| D | THR169 |
| I | ILE136 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | binding site for residue 5C2 E 201 |
| Chain | Residue |
| E | VAL71 |
| E | SER98 |
| E | SER101 |
| E | GLN124 |
| E | PRO125 |
| E | LEU126 |
| E | GLN132 |
| E | HIS142 |
| E | THR146 |
| E | ARG147 |
| E | LEU150 |
| E | ASN151 |
| E | LEU154 |
| E | THR169 |
| M | ILE136 |
| site_id | AC6 |
| Number of Residues | 15 |
| Details | binding site for residue 5C2 F 201 |
| Chain | Residue |
| F | VAL71 |
| F | SER98 |
| F | SER101 |
| F | GLN124 |
| F | PRO125 |
| F | LEU126 |
| F | GLN132 |
| F | HIS142 |
| F | THR146 |
| F | ARG147 |
| F | LEU150 |
| F | ASN151 |
| F | LEU154 |
| F | THR169 |
| L | ILE136 |
| site_id | AC7 |
| Number of Residues | 15 |
| Details | binding site for residue 5C2 G 201 |
| Chain | Residue |
| G | ARG147 |
| G | LEU150 |
| G | ASN151 |
| G | LEU154 |
| G | THR169 |
| H | ILE136 |
| G | VAL71 |
| G | SER98 |
| G | SER101 |
| G | GLN124 |
| G | PRO125 |
| G | LEU126 |
| G | GLN132 |
| G | HIS142 |
| G | THR146 |
| site_id | AC8 |
| Number of Residues | 15 |
| Details | binding site for residue 5C2 H 201 |
| Chain | Residue |
| G | ILE136 |
| H | VAL71 |
| H | SER98 |
| H | SER101 |
| H | GLN124 |
| H | PRO125 |
| H | LEU126 |
| H | GLN132 |
| H | HIS142 |
| H | THR146 |
| H | ARG147 |
| H | LEU150 |
| H | ASN151 |
| H | LEU154 |
| H | THR169 |
| site_id | AC9 |
| Number of Residues | 15 |
| Details | binding site for residue 5C2 I 201 |
| Chain | Residue |
| D | ILE136 |
| I | VAL71 |
| I | SER98 |
| I | SER101 |
| I | GLN124 |
| I | PRO125 |
| I | LEU126 |
| I | GLN132 |
| I | HIS142 |
| I | THR146 |
| I | ARG147 |
| I | LEU150 |
| I | ASN151 |
| I | LEU154 |
| I | THR169 |
| site_id | AD1 |
| Number of Residues | 15 |
| Details | binding site for residue 5C2 J 201 |
| Chain | Residue |
| C | ILE136 |
| J | VAL71 |
| J | SER98 |
| J | SER101 |
| J | GLN124 |
| J | PRO125 |
| J | LEU126 |
| J | GLN132 |
| J | HIS142 |
| J | THR146 |
| J | ARG147 |
| J | LEU150 |
| J | ASN151 |
| J | LEU154 |
| J | THR169 |
| site_id | AD2 |
| Number of Residues | 15 |
| Details | binding site for residue 5C2 K 201 |
| Chain | Residue |
| B | ILE136 |
| K | VAL71 |
| K | SER98 |
| K | SER101 |
| K | GLN124 |
| K | PRO125 |
| K | LEU126 |
| K | GLN132 |
| K | HIS142 |
| K | THR146 |
| K | ARG147 |
| K | LEU150 |
| K | ASN151 |
| K | LEU154 |
| K | THR169 |
| site_id | AD3 |
| Number of Residues | 14 |
| Details | binding site for residue 5C2 L 201 |
| Chain | Residue |
| F | ILE136 |
| L | VAL71 |
| L | SER98 |
| L | SER101 |
| L | HIS123 |
| L | GLN124 |
| L | PRO125 |
| L | LEU126 |
| L | GLN132 |
| L | ILE143 |
| L | THR146 |
| L | ARG147 |
| L | LEU150 |
| L | THR169 |
| site_id | AD4 |
| Number of Residues | 15 |
| Details | binding site for residue 5C2 M 201 |
| Chain | Residue |
| E | ILE136 |
| M | VAL71 |
| M | SER98 |
| M | SER101 |
| M | GLN124 |
| M | PRO125 |
| M | LEU126 |
| M | GLN132 |
| M | HIS142 |
| M | THR146 |
| M | ARG147 |
| M | LEU150 |
| M | ASN151 |
| M | LEU154 |
| M | THR169 |
| site_id | AD5 |
| Number of Residues | 15 |
| Details | binding site for residue 5C2 N 201 |
| Chain | Residue |
| A | ILE136 |
| N | VAL71 |
| N | SER98 |
| N | SER101 |
| N | GLN124 |
| N | PRO125 |
| N | LEU126 |
| N | GLN132 |
| N | HIS142 |
| N | THR146 |
| N | ARG147 |
| N | LEU150 |
| N | ASN151 |
| N | LEU154 |
| N | THR169 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for Ligand ASP E 59 bound to THR D 11 |
| Chain | Residue |
| E | ARG28 |
| E | LYS58 |
| E | ILE60 |
| E | ASP87 |
| E | LYS111 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for Ligand LYS J 85 bound to THR L 11 |
| Chain | Residue |
| J | GLN52 |
| J | SER56 |
| J | ILE84 |
| J | PRO86 |
| J | ASP87 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for Ligand LYS J 85 bound to THR L 11 |
| Chain | Residue |
| J | GLN52 |
| J | SER56 |
| J | ILE84 |
| J | PRO86 |
| J | ASP87 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for Ligand LYS J 85 bound to THR L 11 |
| Chain | Residue |
| J | GLN52 |
| J | SER56 |
| J | ILE84 |
| J | PRO86 |
| J | ASP87 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for Ligand LYS J 85 bound to THR L 11 |
| Chain | Residue |
| J | GLN52 |
| J | SER56 |
| J | ILE84 |
| J | PRO86 |
| J | ASP87 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for Ligand LYS J 85 bound to THR L 11 |
| Chain | Residue |
| J | GLN52 |
| J | SER56 |
| J | ILE84 |
| J | PRO86 |
| J | ASP87 |
| site_id | AE3 |
| Number of Residues | 5 |
| Details | binding site for Ligand LYS J 85 bound to THR L 11 |
| Chain | Residue |
| J | GLN52 |
| J | SER56 |
| J | ILE84 |
| J | PRO86 |
| J | ASP87 |
| site_id | AE4 |
| Number of Residues | 5 |
| Details | binding site for Ligand LYS J 85 bound to THR L 11 |
| Chain | Residue |
| J | GLN52 |
| J | SER56 |
| J | ILE84 |
| J | PRO86 |
| J | ASP87 |
| site_id | AE5 |
| Number of Residues | 5 |
| Details | binding site for Ligand LYS J 85 bound to THR L 11 |
| Chain | Residue |
| J | GLN52 |
| J | SER56 |
| J | ILE84 |
| J | PRO86 |
| J | ASP87 |
| site_id | AE6 |
| Number of Residues | 26 |
| Details | binding site for Di-peptide GLN B 160 and LYS M 167 |
| Chain | Residue |
| B | SER155 |
| B | THR158 |
| B | GLY159 |
| B | SER161 |
| B | GLU163 |
| B | LYS164 |
| B | ILE165 |
| B | GLN166 |
| B | ASP168 |
| B | THR169 |
| B | ASP170 |
| B | ARG171 |
| B | TYR183 |
| M | SER155 |
| M | THR158 |
| M | GLY159 |
| M | SER161 |
| M | GLU163 |
| M | LYS164 |
| M | ILE165 |
| M | GLN166 |
| M | ASP168 |
| M | THR169 |
| M | ASP170 |
| M | ARG171 |
| M | TYR183 |
| site_id | AE7 |
| Number of Residues | 18 |
| Details | binding site for Di-peptide GLU L 9 and GLU J 57 |
| Chain | Residue |
| J | ILE8 |
| J | THR10 |
| J | THR11 |
| J | GLU15 |
| J | ARG16 |
| J | ASP55 |
| J | SER56 |
| J | LYS58 |
| J | ASP59 |
| L | ILE8 |
| L | THR10 |
| L | THR11 |
| L | GLU15 |
| L | ARG16 |
| L | LYS26 |
| L | ASP55 |
| L | SER56 |
| L | LYS58 |
| site_id | AE8 |
| Number of Residues | 18 |
| Details | binding site for Di-peptide GLU L 9 and GLU J 57 |
| Chain | Residue |
| J | ILE8 |
| J | THR10 |
| J | THR11 |
| J | GLU15 |
| J | ARG16 |
| J | ASP55 |
| J | SER56 |
| J | LYS58 |
| J | ASP59 |
| L | ILE8 |
| L | THR10 |
| L | THR11 |
| L | GLU15 |
| L | ARG16 |
| L | LYS26 |
| L | ASP55 |
| L | SER56 |
| L | LYS58 |
| site_id | AE9 |
| Number of Residues | 18 |
| Details | binding site for Di-peptide GLU L 9 and GLU J 57 |
| Chain | Residue |
| J | ILE8 |
| J | THR10 |
| J | THR11 |
| J | GLU15 |
| J | ARG16 |
| J | ASP55 |
| J | SER56 |
| J | LYS58 |
| J | ASP59 |
| L | ILE8 |
| L | THR10 |
| L | THR11 |
| L | GLU15 |
| L | ARG16 |
| L | LYS26 |
| L | ASP55 |
| L | SER56 |
| L | LYS58 |
| site_id | AF1 |
| Number of Residues | 18 |
| Details | binding site for Di-peptide GLU L 9 and GLU J 57 |
| Chain | Residue |
| J | ILE8 |
| J | THR10 |
| J | THR11 |
| J | GLU15 |
| J | ARG16 |
| J | ASP55 |
| J | SER56 |
| J | LYS58 |
| J | ASP59 |
| L | ILE8 |
| L | THR10 |
| L | THR11 |
| L | GLU15 |
| L | ARG16 |
| L | LYS26 |
| L | ASP55 |
| L | SER56 |
| L | LYS58 |
| site_id | AF2 |
| Number of Residues | 18 |
| Details | binding site for Di-peptide GLU L 9 and GLU J 57 |
| Chain | Residue |
| J | ILE8 |
| J | THR10 |
| J | THR11 |
| J | GLU15 |
| J | ARG16 |
| J | ASP55 |
| J | SER56 |
| J | LYS58 |
| J | ASP59 |
| L | ILE8 |
| L | THR10 |
| L | THR11 |
| L | GLU15 |
| L | ARG16 |
| L | LYS26 |
| L | ASP55 |
| L | SER56 |
| L | LYS58 |
| site_id | AF3 |
| Number of Residues | 18 |
| Details | binding site for Di-peptide GLU L 9 and GLU J 57 |
| Chain | Residue |
| J | ILE8 |
| J | THR10 |
| J | THR11 |
| J | GLU15 |
| J | ARG16 |
| J | ASP55 |
| J | SER56 |
| J | LYS58 |
| J | ASP59 |
| L | ILE8 |
| L | THR10 |
| L | THR11 |
| L | GLU15 |
| L | ARG16 |
| L | LYS26 |
| L | ASP55 |
| L | SER56 |
| L | LYS58 |
| site_id | AF4 |
| Number of Residues | 15 |
| Details | binding site for Di-peptide ILE L 162 and GLU J 163 |
| Chain | Residue |
| J | SER155 |
| J | SER161 |
| J | LYS164 |
| J | ILE165 |
| J | GLN166 |
| J | GLN166 |
| J | LYS167 |
| L | SER155 |
| L | SER155 |
| L | SER161 |
| L | SER161 |
| L | LYS164 |
| L | ILE165 |
| L | GLN166 |
| L | LYS167 |
| site_id | AF5 |
| Number of Residues | 15 |
| Details | binding site for Di-peptide ILE L 162 and GLU J 163 |
| Chain | Residue |
| J | SER155 |
| J | SER161 |
| J | LYS164 |
| J | ILE165 |
| J | GLN166 |
| J | GLN166 |
| J | LYS167 |
| L | SER155 |
| L | SER155 |
| L | SER161 |
| L | SER161 |
| L | LYS164 |
| L | ILE165 |
| L | GLN166 |
| L | LYS167 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_00444","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00444","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
