5DKS
Crystal Structure of the ER-alpha Ligand-binding Domain in complex with a 2-naphthylamino-substituted, ethyl, triaryl-ethylene derivative 4,4'-{2-[3-(naphthalen-1-ylamino)phenyl]but-1-ene-1,1-diyl}diphenol
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | binding site for residue 5C6 A 601 |
| Chain | Residue |
| A | MET342 |
| A | GLY415 |
| A | VAL418 |
| A | MET421 |
| A | ILE424 |
| A | PHE425 |
| A | LEU428 |
| A | GLY521 |
| A | LEU525 |
| A | LEU536 |
| A | MET343 |
| A | LEU346 |
| A | THR347 |
| A | GLU353 |
| A | LEU387 |
| A | LEU391 |
| A | ARG394 |
| A | PHE404 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | binding site for residue 5C6 B 601 |
| Chain | Residue |
| B | MET342 |
| B | MET343 |
| B | LEU346 |
| B | THR347 |
| B | ALA350 |
| B | GLU353 |
| B | LEU387 |
| B | LEU391 |
| B | ARG394 |
| B | PHE404 |
| B | MET421 |
| B | ILE424 |
| B | PHE425 |
| B | LEU428 |
| B | GLY521 |
| B | HIS524 |
| B | LEU525 |
| B | LEU540 |
| B | HOH718 |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| C | SER699 | |
| D | SER699 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS447 | |
| B | CYS447 | |
