5DJQ
The structure of CBB3 cytochrome oxidase.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004129 | molecular_function | cytochrome-c oxidase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005507 | molecular_function | copper ion binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006119 | biological_process | oxidative phosphorylation |
| A | 0008121 | molecular_function | ubiquinol-cytochrome-c reductase activity |
| A | 0009060 | biological_process | aerobic respiration |
| A | 0015078 | molecular_function | proton transmembrane transporter activity |
| A | 0015990 | biological_process | electron transport coupled proton transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| A | 0019411 | biological_process | aerobic respiration, using ferrous ions as electron donor |
| A | 0019646 | biological_process | aerobic electron transport chain |
| A | 0019825 | molecular_function | oxygen binding |
| A | 0020037 | molecular_function | heme binding |
| A | 0022904 | biological_process | respiratory electron transport chain |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070069 | cellular_component | cytochrome complex |
| A | 0098803 | cellular_component | respiratory chain complex |
| A | 1902600 | biological_process | proton transmembrane transport |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0016020 | cellular_component | membrane |
| B | 0020037 | molecular_function | heme binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070069 | cellular_component | cytochrome complex |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006119 | biological_process | oxidative phosphorylation |
| C | 0009055 | molecular_function | electron transfer activity |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0020037 | molecular_function | heme binding |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0070069 | cellular_component | cytochrome complex |
| C | 1902600 | biological_process | proton transmembrane transport |
| D | 0004129 | molecular_function | cytochrome-c oxidase activity |
| D | 0005506 | molecular_function | iron ion binding |
| D | 0005507 | molecular_function | copper ion binding |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006119 | biological_process | oxidative phosphorylation |
| D | 0008121 | molecular_function | ubiquinol-cytochrome-c reductase activity |
| D | 0009060 | biological_process | aerobic respiration |
| D | 0015078 | molecular_function | proton transmembrane transporter activity |
| D | 0015990 | biological_process | electron transport coupled proton transport |
| D | 0016020 | cellular_component | membrane |
| D | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| D | 0019411 | biological_process | aerobic respiration, using ferrous ions as electron donor |
| D | 0019646 | biological_process | aerobic electron transport chain |
| D | 0019825 | molecular_function | oxygen binding |
| D | 0020037 | molecular_function | heme binding |
| D | 0022904 | biological_process | respiratory electron transport chain |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0070069 | cellular_component | cytochrome complex |
| D | 0098803 | cellular_component | respiratory chain complex |
| D | 1902600 | biological_process | proton transmembrane transport |
| E | 0009055 | molecular_function | electron transfer activity |
| E | 0016020 | cellular_component | membrane |
| E | 0020037 | molecular_function | heme binding |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0070069 | cellular_component | cytochrome complex |
| F | 0005886 | cellular_component | plasma membrane |
| F | 0006119 | biological_process | oxidative phosphorylation |
| F | 0009055 | molecular_function | electron transfer activity |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0020037 | molecular_function | heme binding |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0070069 | cellular_component | cytochrome complex |
| F | 1902600 | biological_process | proton transmembrane transport |
| G | 0004129 | molecular_function | cytochrome-c oxidase activity |
| G | 0005506 | molecular_function | iron ion binding |
| G | 0005507 | molecular_function | copper ion binding |
| G | 0005886 | cellular_component | plasma membrane |
| G | 0006119 | biological_process | oxidative phosphorylation |
| G | 0008121 | molecular_function | ubiquinol-cytochrome-c reductase activity |
| G | 0009060 | biological_process | aerobic respiration |
| G | 0015078 | molecular_function | proton transmembrane transporter activity |
| G | 0015990 | biological_process | electron transport coupled proton transport |
| G | 0016020 | cellular_component | membrane |
| G | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| G | 0019411 | biological_process | aerobic respiration, using ferrous ions as electron donor |
| G | 0019646 | biological_process | aerobic electron transport chain |
| G | 0019825 | molecular_function | oxygen binding |
| G | 0020037 | molecular_function | heme binding |
| G | 0022904 | biological_process | respiratory electron transport chain |
| G | 0046872 | molecular_function | metal ion binding |
| G | 0070069 | cellular_component | cytochrome complex |
| G | 0098803 | cellular_component | respiratory chain complex |
| G | 1902600 | biological_process | proton transmembrane transport |
| H | 0009055 | molecular_function | electron transfer activity |
| H | 0016020 | cellular_component | membrane |
| H | 0020037 | molecular_function | heme binding |
| H | 0046872 | molecular_function | metal ion binding |
| H | 0070069 | cellular_component | cytochrome complex |
| I | 0005886 | cellular_component | plasma membrane |
| I | 0006119 | biological_process | oxidative phosphorylation |
| I | 0009055 | molecular_function | electron transfer activity |
| I | 0016491 | molecular_function | oxidoreductase activity |
| I | 0020037 | molecular_function | heme binding |
| I | 0046872 | molecular_function | metal ion binding |
| I | 0070069 | cellular_component | cytochrome complex |
| I | 1902600 | biological_process | proton transmembrane transport |
| K | 0004129 | molecular_function | cytochrome-c oxidase activity |
| K | 0005506 | molecular_function | iron ion binding |
| K | 0005507 | molecular_function | copper ion binding |
| K | 0005886 | cellular_component | plasma membrane |
| K | 0006119 | biological_process | oxidative phosphorylation |
| K | 0008121 | molecular_function | ubiquinol-cytochrome-c reductase activity |
| K | 0009060 | biological_process | aerobic respiration |
| K | 0015078 | molecular_function | proton transmembrane transporter activity |
| K | 0015990 | biological_process | electron transport coupled proton transport |
| K | 0016020 | cellular_component | membrane |
| K | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| K | 0019411 | biological_process | aerobic respiration, using ferrous ions as electron donor |
| K | 0019646 | biological_process | aerobic electron transport chain |
| K | 0019825 | molecular_function | oxygen binding |
| K | 0020037 | molecular_function | heme binding |
| K | 0022904 | biological_process | respiratory electron transport chain |
| K | 0046872 | molecular_function | metal ion binding |
| K | 0070069 | cellular_component | cytochrome complex |
| K | 0098803 | cellular_component | respiratory chain complex |
| K | 1902600 | biological_process | proton transmembrane transport |
| L | 0009055 | molecular_function | electron transfer activity |
| L | 0016020 | cellular_component | membrane |
| L | 0020037 | molecular_function | heme binding |
| L | 0046872 | molecular_function | metal ion binding |
| L | 0070069 | cellular_component | cytochrome complex |
| M | 0005886 | cellular_component | plasma membrane |
| M | 0006119 | biological_process | oxidative phosphorylation |
| M | 0009055 | molecular_function | electron transfer activity |
| M | 0016491 | molecular_function | oxidoreductase activity |
| M | 0020037 | molecular_function | heme binding |
| M | 0046872 | molecular_function | metal ion binding |
| M | 0070069 | cellular_component | cytochrome complex |
| M | 1902600 | biological_process | proton transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | binding site for residue HEM A 501 |
| Chain | Residue |
| A | GLU122 |
| A | GLY324 |
| A | PRO325 |
| A | MET327 |
| A | ALA328 |
| A | ASN333 |
| A | HIS337 |
| A | HIS345 |
| A | VAL346 |
| A | GLY349 |
| A | HEM502 |
| A | TYR123 |
| A | PEO505 |
| A | CA507 |
| B | SER102 |
| A | TRP203 |
| A | VAL210 |
| A | TYR251 |
| A | HIS257 |
| A | HIS258 |
| A | LEU279 |
| A | SER283 |
| site_id | AC2 |
| Number of Residues | 23 |
| Details | binding site for residue HEM A 502 |
| Chain | Residue |
| A | MET29 |
| A | GLY32 |
| A | VAL33 |
| A | ALA36 |
| A | ARG57 |
| A | HIS60 |
| A | VAL64 |
| A | ILE65 |
| A | GLU122 |
| A | TYR123 |
| A | ASP340 |
| A | ILE343 |
| A | VAL346 |
| A | HIS347 |
| A | ALA350 |
| A | LEU351 |
| A | TYR395 |
| A | ARG437 |
| A | GLY441 |
| A | PHE444 |
| A | HEM501 |
| A | CA507 |
| B | LYS103 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue CU A 503 |
| Chain | Residue |
| A | HIS207 |
| A | HIS257 |
| A | HIS258 |
| A | PEO505 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 504 |
| Chain | Residue |
| A | ALA124 |
| A | LEU126 |
| A | ASP131 |
| A | ASN179 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue PEO A 505 |
| Chain | Residue |
| A | HIS207 |
| A | VAL210 |
| A | HIS258 |
| A | HEM501 |
| A | CU503 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 A 506 |
| Chain | Residue |
| A | MET273 |
| A | ILE329 |
| A | LYS330 |
| A | THR331 |
| C | TYR72 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 507 |
| Chain | Residue |
| A | ARG57 |
| A | GLU122 |
| A | HEM501 |
| A | HEM502 |
| B | SER102 |
| site_id | AC8 |
| Number of Residues | 21 |
| Details | binding site for residue HEC B 301 |
| Chain | Residue |
| A | PHE53 |
| A | LEU427 |
| B | GLU63 |
| B | CYS65 |
| B | CYS68 |
| B | HIS69 |
| B | THR105 |
| B | GLY106 |
| B | PRO107 |
| B | LEU109 |
| B | TYR116 |
| B | HIS121 |
| B | HIS124 |
| B | LEU125 |
| B | VAL132 |
| B | SER135 |
| B | LYS136 |
| B | MET137 |
| B | PRO138 |
| B | TYR140 |
| B | MET188 |
| site_id | AC9 |
| Number of Residues | 22 |
| Details | binding site for residue HEC C 401 |
| Chain | Residue |
| C | LEU247 |
| C | GLY248 |
| C | PRO250 |
| C | TRP258 |
| C | ILE259 |
| C | TYR260 |
| C | LEU267 |
| C | THR270 |
| C | ILE271 |
| C | GLY277 |
| C | HEC402 |
| I | ILE183 |
| C | ARG166 |
| C | ALA184 |
| C | ALA185 |
| C | MET186 |
| C | PRO187 |
| C | TRP189 |
| C | THR232 |
| C | CYS233 |
| C | CYS236 |
| C | HIS237 |
| site_id | AD1 |
| Number of Residues | 22 |
| Details | binding site for residue HEC C 402 |
| Chain | Residue |
| B | TYR116 |
| C | TYR142 |
| C | CYS143 |
| C | CYS146 |
| C | HIS147 |
| C | GLY156 |
| C | PHE157 |
| C | PRO158 |
| C | LEU160 |
| C | TRP165 |
| C | ARG166 |
| C | TRP167 |
| C | ILE174 |
| C | SER177 |
| C | ILE178 |
| C | ALA184 |
| C | GLY277 |
| C | GLN278 |
| C | MET279 |
| C | PRO280 |
| C | GLN282 |
| C | HEC401 |
| site_id | AD2 |
| Number of Residues | 8 |
| Details | binding site for residue FC6 C 403 |
| Chain | Residue |
| C | GLY265 |
| C | GLN266 |
| C | GLN269 |
| C | ARG275 |
| M | ARG206 |
| M | PRO215 |
| M | SER263 |
| M | LEU264 |
| site_id | AD3 |
| Number of Residues | 22 |
| Details | binding site for residue HEM D 501 |
| Chain | Residue |
| D | GLU122 |
| D | TYR123 |
| D | TRP203 |
| D | VAL210 |
| D | TYR251 |
| D | HIS257 |
| D | HIS258 |
| D | LEU279 |
| D | SER283 |
| D | SER320 |
| D | GLY324 |
| D | PRO325 |
| D | MET327 |
| D | ALA328 |
| D | ASN333 |
| D | HIS337 |
| D | HIS345 |
| D | VAL346 |
| D | HEM502 |
| D | PEO506 |
| D | CA507 |
| E | SER102 |
| site_id | AD4 |
| Number of Residues | 23 |
| Details | binding site for residue HEM D 502 |
| Chain | Residue |
| D | MET29 |
| D | GLY32 |
| D | VAL33 |
| D | ALA36 |
| D | ARG57 |
| D | HIS60 |
| D | VAL64 |
| D | ILE65 |
| D | GLU122 |
| D | TYR123 |
| D | ASP340 |
| D | ILE343 |
| D | VAL346 |
| D | HIS347 |
| D | ALA350 |
| D | LEU351 |
| D | TYR395 |
| D | ARG437 |
| D | GLY441 |
| D | PHE444 |
| D | HEM501 |
| D | CA507 |
| E | LYS103 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue CU D 503 |
| Chain | Residue |
| D | HIS207 |
| D | HIS257 |
| D | HIS258 |
| D | PEO506 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue CA D 504 |
| Chain | Residue |
| D | SER119 |
| D | ALA124 |
| D | LEU126 |
| D | ASP131 |
| D | ASN179 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 D 505 |
| Chain | Residue |
| D | MET273 |
| D | ILE329 |
| D | LYS330 |
| D | THR331 |
| F | TYR72 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue PEO D 506 |
| Chain | Residue |
| D | HIS207 |
| D | VAL210 |
| D | HIS258 |
| D | HEM501 |
| D | CU503 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue CA D 507 |
| Chain | Residue |
| D | ARG57 |
| D | GLU122 |
| D | HEM501 |
| D | HEM502 |
| E | SER102 |
| site_id | AE1 |
| Number of Residues | 9 |
| Details | binding site for residue FC6 F 403 |
| Chain | Residue |
| F | TYR260 |
| F | GLY265 |
| F | GLN266 |
| F | GLN269 |
| F | ARG275 |
| I | ARG206 |
| I | PRO215 |
| I | SER263 |
| I | LEU264 |
| site_id | AE2 |
| Number of Residues | 22 |
| Details | binding site for residue HEM G 501 |
| Chain | Residue |
| G | GLU122 |
| G | TYR123 |
| G | TRP203 |
| G | VAL210 |
| G | TYR251 |
| G | HIS257 |
| G | HIS258 |
| G | LEU279 |
| G | SER283 |
| G | SER320 |
| G | GLY324 |
| G | PRO325 |
| G | MET327 |
| G | ALA328 |
| G | ASN333 |
| G | HIS337 |
| G | HIS345 |
| G | VAL346 |
| G | HEM502 |
| G | PEO505 |
| G | CA507 |
| H | SER102 |
| site_id | AE3 |
| Number of Residues | 25 |
| Details | binding site for residue HEM G 502 |
| Chain | Residue |
| G | MET29 |
| G | GLY32 |
| G | VAL33 |
| G | ILE35 |
| G | ALA36 |
| G | ARG57 |
| G | HIS60 |
| G | VAL64 |
| G | ILE65 |
| G | GLU122 |
| G | TYR123 |
| G | ASP340 |
| G | THR342 |
| G | ILE343 |
| G | VAL346 |
| G | HIS347 |
| G | ALA350 |
| G | LEU351 |
| G | TYR395 |
| G | ARG437 |
| G | GLY441 |
| G | PHE444 |
| G | HEM501 |
| G | CA507 |
| H | LYS103 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue CU G 503 |
| Chain | Residue |
| G | HIS207 |
| G | HIS257 |
| G | HIS258 |
| G | PEO505 |
| site_id | AE5 |
| Number of Residues | 5 |
| Details | binding site for residue CA G 504 |
| Chain | Residue |
| G | SER119 |
| G | ALA124 |
| G | LEU126 |
| G | ASP131 |
| G | ASN179 |
| site_id | AE6 |
| Number of Residues | 5 |
| Details | binding site for residue PEO G 505 |
| Chain | Residue |
| G | HIS207 |
| G | VAL210 |
| G | HIS258 |
| G | HEM501 |
| G | CU503 |
| site_id | AE7 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 G 506 |
| Chain | Residue |
| G | MET273 |
| G | ILE329 |
| G | LYS330 |
| G | THR331 |
| I | TYR72 |
| site_id | AE8 |
| Number of Residues | 5 |
| Details | binding site for residue CA G 507 |
| Chain | Residue |
| G | ARG57 |
| G | GLU122 |
| G | HEM501 |
| G | HEM502 |
| H | SER102 |
| site_id | AE9 |
| Number of Residues | 8 |
| Details | binding site for residue FC6 I 401 |
| Chain | Residue |
| F | ARG206 |
| F | PRO215 |
| F | SER263 |
| F | LEU264 |
| I | GLY265 |
| I | GLN266 |
| I | GLN269 |
| I | ARG275 |
| site_id | AF1 |
| Number of Residues | 24 |
| Details | binding site for residue HEM K 501 |
| Chain | Residue |
| K | GLU122 |
| K | TYR123 |
| K | TRP203 |
| K | VAL210 |
| K | LEU214 |
| K | HIS257 |
| K | LEU279 |
| K | SER283 |
| K | SER320 |
| K | GLY324 |
| K | PRO325 |
| K | MET327 |
| K | ALA328 |
| K | ASN333 |
| K | HIS337 |
| K | THR342 |
| K | HIS345 |
| K | VAL346 |
| K | GLY349 |
| K | HEM502 |
| K | CU503 |
| K | CA504 |
| K | PEO507 |
| L | SER102 |
| site_id | AF2 |
| Number of Residues | 26 |
| Details | binding site for residue HEM K 502 |
| Chain | Residue |
| K | MET29 |
| K | GLY32 |
| K | VAL33 |
| K | ILE35 |
| K | ALA36 |
| K | LEU39 |
| K | ARG57 |
| K | HIS60 |
| K | THR61 |
| K | VAL64 |
| K | ILE65 |
| K | GLU122 |
| K | TYR123 |
| K | ASP340 |
| K | ILE343 |
| K | VAL346 |
| K | HIS347 |
| K | ALA350 |
| K | LEU351 |
| K | TYR395 |
| K | ARG437 |
| K | GLY441 |
| K | PHE444 |
| K | HEM501 |
| K | CA504 |
| L | LYS103 |
| site_id | AF3 |
| Number of Residues | 5 |
| Details | binding site for residue CU K 503 |
| Chain | Residue |
| K | HIS207 |
| K | HIS257 |
| K | HIS258 |
| K | HEM501 |
| K | PEO507 |
| site_id | AF4 |
| Number of Residues | 5 |
| Details | binding site for residue CA K 504 |
| Chain | Residue |
| K | ARG57 |
| K | GLU122 |
| K | HEM501 |
| K | HEM502 |
| L | SER102 |
| site_id | AF5 |
| Number of Residues | 4 |
| Details | binding site for residue CA K 505 |
| Chain | Residue |
| K | ALA124 |
| K | LEU126 |
| K | ASP131 |
| K | ASN179 |
| site_id | AF6 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 K 506 |
| Chain | Residue |
| K | MET273 |
| K | ILE329 |
| K | LYS330 |
| K | THR331 |
| M | TYR72 |
| site_id | AF7 |
| Number of Residues | 5 |
| Details | binding site for residue PEO K 507 |
| Chain | Residue |
| K | HIS207 |
| K | VAL210 |
| K | HIS258 |
| K | HEM501 |
| K | CU503 |
| site_id | AF8 |
| Number of Residues | 8 |
| Details | binding site for residue FC6 M 401 |
| Chain | Residue |
| C | ARG206 |
| C | PRO215 |
| C | SER263 |
| C | LEU264 |
| M | GLY265 |
| M | GLN266 |
| M | GLN269 |
| M | ARG275 |
| site_id | AF9 |
| Number of Residues | 25 |
| Details | binding site for Di-peptide HEC E 301 and CYS E 65 |
| Chain | Residue |
| D | PHE53 |
| D | LEU427 |
| E | TYR60 |
| E | GLU63 |
| E | GLY64 |
| E | VAL66 |
| E | GLY67 |
| E | CYS68 |
| E | HIS69 |
| E | THR105 |
| E | GLY106 |
| E | PRO107 |
| E | LEU109 |
| E | TYR116 |
| E | TRP120 |
| E | HIS121 |
| E | HIS124 |
| E | LEU125 |
| E | VAL132 |
| E | SER135 |
| E | MET137 |
| E | PRO138 |
| E | TYR140 |
| E | MET188 |
| F | ILE145 |
| site_id | AG1 |
| Number of Residues | 25 |
| Details | binding site for Di-peptide HEC E 301 and CYS E 68 |
| Chain | Residue |
| D | PHE53 |
| D | LEU427 |
| E | GLU63 |
| E | CYS65 |
| E | VAL66 |
| E | GLY67 |
| E | HIS69 |
| E | LYS103 |
| E | ARG104 |
| E | THR105 |
| E | GLY106 |
| E | PRO107 |
| E | LEU109 |
| E | TYR116 |
| E | TRP120 |
| E | HIS121 |
| E | HIS124 |
| E | LEU125 |
| E | VAL132 |
| E | SER135 |
| E | MET137 |
| E | PRO138 |
| E | TYR140 |
| E | MET188 |
| F | ILE145 |
| site_id | AG2 |
| Number of Residues | 24 |
| Details | binding site for Di-peptide HEC F 401 and CYS F 233 |
| Chain | Residue |
| F | ARG166 |
| F | ALA184 |
| F | ALA185 |
| F | MET186 |
| F | PRO187 |
| F | TRP189 |
| F | TYR229 |
| F | THR232 |
| F | ALA234 |
| F | VAL235 |
| F | CYS236 |
| F | HIS237 |
| F | LEU247 |
| F | GLY248 |
| F | ALA249 |
| F | PRO250 |
| F | TRP258 |
| F | ILE259 |
| F | TYR260 |
| F | LEU267 |
| F | THR270 |
| F | ILE271 |
| F | GLY277 |
| F | HEC402 |
| site_id | AG3 |
| Number of Residues | 25 |
| Details | binding site for Di-peptide HEC F 401 and CYS F 236 |
| Chain | Residue |
| F | ARG166 |
| F | ALA184 |
| F | ALA185 |
| F | MET186 |
| F | PRO187 |
| F | TRP189 |
| F | THR232 |
| F | CYS233 |
| F | ALA234 |
| F | VAL235 |
| F | HIS237 |
| F | GLY238 |
| F | MET244 |
| F | LEU247 |
| F | GLY248 |
| F | ALA249 |
| F | PRO250 |
| F | TRP258 |
| F | ILE259 |
| F | TYR260 |
| F | LEU267 |
| F | THR270 |
| F | ILE271 |
| F | GLY277 |
| F | HEC402 |
| site_id | AG4 |
| Number of Residues | 23 |
| Details | binding site for Di-peptide HEC F 402 and CYS F 143 |
| Chain | Residue |
| E | TYR116 |
| E | SER117 |
| F | PHE139 |
| F | TYR142 |
| F | SER144 |
| F | ILE145 |
| F | CYS146 |
| F | HIS147 |
| F | GLY156 |
| F | PRO158 |
| F | LEU160 |
| F | TRP165 |
| F | ARG166 |
| F | TRP167 |
| F | SER177 |
| F | ILE178 |
| F | ALA184 |
| F | GLY277 |
| F | GLN278 |
| F | MET279 |
| F | PRO280 |
| F | GLN282 |
| F | HEC401 |
| site_id | AG5 |
| Number of Residues | 23 |
| Details | binding site for Di-peptide HEC F 402 and CYS F 146 |
| Chain | Residue |
| E | TYR116 |
| E | SER117 |
| F | CYS143 |
| F | SER144 |
| F | ILE145 |
| F | HIS147 |
| F | GLY148 |
| F | GLY156 |
| F | PHE157 |
| F | PRO158 |
| F | LEU160 |
| F | TRP165 |
| F | ARG166 |
| F | TRP167 |
| F | SER177 |
| F | ILE178 |
| F | ALA184 |
| F | GLY277 |
| F | GLN278 |
| F | MET279 |
| F | PRO280 |
| F | GLN282 |
| F | HEC401 |
| site_id | AG6 |
| Number of Residues | 26 |
| Details | binding site for Di-peptide HEC H 301 and CYS H 68 |
| Chain | Residue |
| G | PHE53 |
| G | LEU427 |
| H | GLU63 |
| H | CYS65 |
| H | VAL66 |
| H | GLY67 |
| H | HIS69 |
| H | LYS103 |
| H | ARG104 |
| H | THR105 |
| H | GLY106 |
| H | PRO107 |
| H | LEU109 |
| H | TYR116 |
| H | TRP120 |
| H | HIS121 |
| H | HIS124 |
| H | LEU125 |
| H | VAL132 |
| H | SER135 |
| H | LYS136 |
| H | MET137 |
| H | PRO138 |
| H | TYR140 |
| H | MET188 |
| I | ILE145 |
| site_id | AG7 |
| Number of Residues | 26 |
| Details | binding site for Di-peptide HEC H 301 and CYS H 65 |
| Chain | Residue |
| G | PHE53 |
| G | LEU427 |
| H | TYR60 |
| H | GLU63 |
| H | GLY64 |
| H | VAL66 |
| H | GLY67 |
| H | CYS68 |
| H | HIS69 |
| H | THR105 |
| H | GLY106 |
| H | PRO107 |
| H | LEU109 |
| H | TYR116 |
| H | TRP120 |
| H | HIS121 |
| H | HIS124 |
| H | LEU125 |
| H | VAL132 |
| H | SER135 |
| H | LYS136 |
| H | MET137 |
| H | PRO138 |
| H | TYR140 |
| H | MET188 |
| I | ILE145 |
| site_id | AG8 |
| Number of Residues | 26 |
| Details | binding site for Di-peptide HEC I 402 and CYS I 233 |
| Chain | Residue |
| C | ILE183 |
| I | ARG166 |
| I | ALA184 |
| I | ALA185 |
| I | MET186 |
| I | PRO187 |
| I | TRP189 |
| I | TYR229 |
| I | THR232 |
| I | ALA234 |
| I | VAL235 |
| I | CYS236 |
| I | HIS237 |
| I | LEU247 |
| I | GLY248 |
| I | PRO250 |
| I | LEU252 |
| I | TRP258 |
| I | ILE259 |
| I | TYR260 |
| I | GLY261 |
| I | LEU267 |
| I | THR270 |
| I | ILE271 |
| I | GLY277 |
| I | HEC403 |
| site_id | AG9 |
| Number of Residues | 28 |
| Details | binding site for Di-peptide HEC I 402 and CYS I 236 |
| Chain | Residue |
| C | ILE183 |
| I | ARG166 |
| I | ALA184 |
| I | ALA185 |
| I | MET186 |
| I | PRO187 |
| I | TRP189 |
| I | THR232 |
| I | CYS233 |
| I | ALA234 |
| I | VAL235 |
| I | HIS237 |
| I | GLY238 |
| I | MET244 |
| I | LEU247 |
| I | GLY248 |
| I | ALA249 |
| I | PRO250 |
| I | LEU252 |
| I | TRP258 |
| I | ILE259 |
| I | TYR260 |
| I | GLY261 |
| I | LEU267 |
| I | THR270 |
| I | ILE271 |
| I | GLY277 |
| I | HEC403 |
| site_id | AH1 |
| Number of Residues | 24 |
| Details | binding site for Di-peptide HEC I 403 and CYS I 146 |
| Chain | Residue |
| H | TYR116 |
| H | TRP120 |
| I | TYR142 |
| I | CYS143 |
| I | SER144 |
| I | ILE145 |
| I | HIS147 |
| I | GLY148 |
| I | GLY156 |
| I | PHE157 |
| I | PRO158 |
| I | TRP165 |
| I | ARG166 |
| I | TRP167 |
| I | ILE174 |
| I | SER177 |
| I | ILE178 |
| I | ALA184 |
| I | GLY277 |
| I | GLN278 |
| I | MET279 |
| I | PRO280 |
| I | GLN282 |
| I | HEC402 |
| site_id | AH2 |
| Number of Residues | 22 |
| Details | binding site for Di-peptide HEC I 403 and CYS I 143 |
| Chain | Residue |
| H | TYR116 |
| I | PHE139 |
| I | TYR142 |
| I | SER144 |
| I | ILE145 |
| I | CYS146 |
| I | HIS147 |
| I | GLY156 |
| I | PRO158 |
| I | TRP165 |
| I | ARG166 |
| I | TRP167 |
| I | ILE174 |
| I | SER177 |
| I | ILE178 |
| I | ALA184 |
| I | GLY277 |
| I | GLN278 |
| I | MET279 |
| I | PRO280 |
| I | GLN282 |
| I | HEC402 |
| site_id | AH3 |
| Number of Residues | 22 |
| Details | binding site for Di-peptide HEC L 301 and CYS L 68 |
| Chain | Residue |
| K | PHE53 |
| K | LEU427 |
| L | GLU63 |
| L | CYS65 |
| L | VAL66 |
| L | GLY67 |
| L | HIS69 |
| L | LYS103 |
| L | ARG104 |
| L | THR105 |
| L | GLY106 |
| L | PRO107 |
| L | TYR116 |
| L | TRP120 |
| L | HIS121 |
| L | HIS124 |
| L | VAL132 |
| L | SER135 |
| L | MET137 |
| L | PRO138 |
| L | TYR140 |
| L | MET188 |
| site_id | AH4 |
| Number of Residues | 22 |
| Details | binding site for Di-peptide HEC L 301 and CYS L 65 |
| Chain | Residue |
| K | PHE53 |
| K | LEU427 |
| L | TYR60 |
| L | GLU63 |
| L | GLY64 |
| L | VAL66 |
| L | GLY67 |
| L | CYS68 |
| L | HIS69 |
| L | THR105 |
| L | GLY106 |
| L | PRO107 |
| L | TYR116 |
| L | TRP120 |
| L | HIS121 |
| L | HIS124 |
| L | VAL132 |
| L | SER135 |
| L | MET137 |
| L | PRO138 |
| L | TYR140 |
| L | MET188 |
| site_id | AH5 |
| Number of Residues | 27 |
| Details | binding site for Di-peptide HEC M 402 and CYS M 233 |
| Chain | Residue |
| M | ARG166 |
| M | ILE183 |
| M | ALA184 |
| M | ALA185 |
| M | MET186 |
| M | PRO187 |
| M | TRP189 |
| M | VAL205 |
| M | TYR229 |
| M | THR232 |
| M | ALA234 |
| M | VAL235 |
| M | CYS236 |
| M | HIS237 |
| M | LEU247 |
| M | GLY248 |
| M | PRO250 |
| M | LEU252 |
| M | TRP258 |
| M | ILE259 |
| M | TYR260 |
| M | GLY261 |
| M | LEU267 |
| M | THR270 |
| M | ILE271 |
| M | GLY277 |
| M | HEC403 |
| site_id | AH6 |
| Number of Residues | 29 |
| Details | binding site for Di-peptide HEC M 402 and CYS M 236 |
| Chain | Residue |
| M | ARG166 |
| M | ILE183 |
| M | ALA184 |
| M | ALA185 |
| M | MET186 |
| M | PRO187 |
| M | TRP189 |
| M | VAL205 |
| M | THR232 |
| M | CYS233 |
| M | ALA234 |
| M | VAL235 |
| M | HIS237 |
| M | GLY238 |
| M | MET244 |
| M | LEU247 |
| M | GLY248 |
| M | ALA249 |
| M | PRO250 |
| M | LEU252 |
| M | TRP258 |
| M | ILE259 |
| M | TYR260 |
| M | GLY261 |
| M | LEU267 |
| M | THR270 |
| M | ILE271 |
| M | GLY277 |
| M | HEC403 |
| site_id | AH7 |
| Number of Residues | 24 |
| Details | binding site for Di-peptide HEC M 403 and CYS M 146 |
| Chain | Residue |
| L | TYR116 |
| M | TYR142 |
| M | CYS143 |
| M | SER144 |
| M | ILE145 |
| M | HIS147 |
| M | GLY148 |
| M | GLY156 |
| M | PHE157 |
| M | PRO158 |
| M | LEU160 |
| M | TRP165 |
| M | ARG166 |
| M | TRP167 |
| M | ILE174 |
| M | SER177 |
| M | ILE178 |
| M | ALA184 |
| M | GLY277 |
| M | GLN278 |
| M | MET279 |
| M | PRO280 |
| M | GLN282 |
| M | HEC402 |
| site_id | AH8 |
| Number of Residues | 23 |
| Details | binding site for Di-peptide HEC M 403 and CYS M 143 |
| Chain | Residue |
| L | TYR116 |
| M | PHE139 |
| M | TYR142 |
| M | SER144 |
| M | ILE145 |
| M | CYS146 |
| M | HIS147 |
| M | GLY156 |
| M | PRO158 |
| M | LEU160 |
| M | TRP165 |
| M | ARG166 |
| M | TRP167 |
| M | ILE174 |
| M | SER177 |
| M | ILE178 |
| M | ALA184 |
| M | GLY277 |
| M | GLN278 |
| M | MET279 |
| M | PRO280 |
| M | GLN282 |
| M | HEC402 |
Functional Information from PROSITE/UniProt
| site_id | PS00077 |
| Number of Residues | 56 |
| Details | COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WWYGHNaVgffltagflgimyyfvpkqaerpvysyrlsivhfwalitvyiwagp.HH |
| Chain | Residue | Details |
| A | TRP203-HIS258 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 160 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:20576851 |
| Chain | Residue | Details |
| C | PHE4-ILE24 | |
| D | LYS151-HIS156 | |
| D | PRO227-ARG238 | |
| D | MET292-ARG308 | |
| D | PRO367-HIS384 | |
| D | ASN454-ALA474 | |
| G | MET1-GLN16 | |
| G | GLN82-ALA96 | |
| G | LYS151-HIS156 | |
| G | PRO227-ARG238 | |
| G | MET292-ARG308 | |
| C | ARG56-TYR76 | |
| G | PRO367-HIS384 | |
| G | ASN454-ALA474 | |
| K | MET1-GLN16 | |
| K | GLN82-ALA96 | |
| K | LYS151-HIS156 | |
| K | PRO227-ARG238 | |
| K | MET292-ARG308 | |
| K | PRO367-HIS384 | |
| K | ASN454-ALA474 | |
| F | PHE4-ILE24 | |
| F | ARG56-TYR76 | |
| I | PHE4-ILE24 | |
| I | ARG56-TYR76 | |
| M | PHE4-ILE24 | |
| M | ARG56-TYR76 | |
| D | GLN82-ALA96 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | BINDING: covalent => ECO:0000269|PubMed:20576851 |
| Chain | Residue | Details |
| C | CYS143 | |
| I | CYS146 | |
| I | CYS233 | |
| I | CYS236 | |
| M | CYS143 | |
| M | CYS146 | |
| M | CYS233 | |
| M | CYS236 | |
| D | ILE157-VAL177 | |
| D | GLY206-VAL226 | |
| D | LEU239-LEU259 | |
| C | CYS146 | |
| D | LEU271-MET291 | |
| D | PHE309-ILE329 | |
| D | VAL346-VAL366 | |
| D | PHE385-ALA405 | |
| D | GLY433-TYR453 | |
| G | PHE17-ALA37 | |
| G | THR61-VAL81 | |
| G | PHE97-PHE117 | |
| G | ILE130-ALA150 | |
| G | ILE157-VAL177 | |
| C | CYS233 | |
| G | GLY206-VAL226 | |
| G | LEU239-LEU259 | |
| G | LEU271-MET291 | |
| G | PHE309-ILE329 | |
| G | VAL346-VAL366 | |
| G | PHE385-ALA405 | |
| G | GLY433-TYR453 | |
| K | PHE17-ALA37 | |
| K | THR61-VAL81 | |
| K | PHE97-PHE117 | |
| C | CYS236 | |
| K | ILE130-ALA150 | |
| K | ILE157-VAL177 | |
| K | GLY206-VAL226 | |
| K | LEU239-LEU259 | |
| K | LEU271-MET291 | |
| K | PHE309-ILE329 | |
| K | VAL346-VAL366 | |
| K | PHE385-ALA405 | |
| K | GLY433-TYR453 | |
| F | CYS143 | |
| F | CYS146 | |
| F | CYS233 | |
| F | CYS236 | |
| I | CYS143 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | BINDING: axial binding residue => ECO:0000269|PubMed:20576851 |
| Chain | Residue | Details |
| C | HIS147 | |
| I | MET186 | |
| I | HIS237 | |
| I | MET279 | |
| M | HIS147 | |
| M | MET186 | |
| M | HIS237 | |
| M | MET279 | |
| G | LYS330-HIS345 | |
| G | GLN406-PRO432 | |
| K | GLN38-HIS60 | |
| C | MET186 | |
| K | THR118-PRO129 | |
| K | ASN178-TYR205 | |
| K | HIS260-SER270 | |
| K | LYS330-HIS345 | |
| K | GLN406-PRO432 | |
| C | HIS237 | |
| C | MET279 | |
| F | HIS147 | |
| F | MET186 | |
| F | HIS237 | |
| F | MET279 | |
| I | HIS147 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | BINDING: axial binding residue => ECO:0000269|PubMed:20576851, ECO:0007744|PDB:3MK7 |
| Chain | Residue | Details |
| A | HIS60 | |
| K | HIS60 | |
| K | HIS345 | |
| K | HIS347 | |
| A | HIS345 | |
| A | HIS347 | |
| D | HIS60 | |
| D | HIS345 | |
| D | HIS347 | |
| G | HIS60 | |
| G | HIS345 | |
| G | HIS347 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20576851, ECO:0007744|PDB:3MK7 |
| Chain | Residue | Details |
| A | HIS207 | |
| K | HIS207 | |
| K | HIS257 | |
| K | HIS258 | |
| A | HIS257 | |
| A | HIS258 | |
| D | HIS207 | |
| D | HIS257 | |
| D | HIS258 | |
| G | HIS207 | |
| G | HIS257 | |
| G | HIS258 |
