5DGJ

1.0A resolution structure of Norovirus 3CL protease in complex an oxadiazole-based, cell permeable macrocyclic (20-mer) inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue V64 A 201

Chain	Residue
A	HIS30
A	ALA159
A	ALA160
A	HOH341
A	GLU54
A	ILE109
A	GLN110
A	GLY137
A	ASP138
A	CYS139
A	HIS157
A	ALA158

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Active site: {"description":"For 3CLpro activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00870","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16641296","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23365454","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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