5DGI

Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP and 3,5-(PCP)2-IP4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000829	molecular_function	diphosphoinositol pentakisphosphate kinase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	binding site for residue ADP A 401

Chain	Residue
A	ARG134
A	MET240
A	ASP246
A	SER264
A	PRO265
A	ASP309
A	LEU311
A	CYS320
A	ASP321
A	MG403
A	MG404
A	PRO149
A	HOH519
A	HOH549
A	HOH694
A	HOH736
A	VAL185
A	LYS187
A	HIS194
A	LEU211
A	GLU237
A	GLU238
A	PHE239

---

site_id	AC2
Number of Residues	22
Details	binding site for residue 5A2 A 402

Chain	Residue
A	LYS53
A	LYS54
A	SER102
A	LYS103
A	ARG213
A	LYS214
A	TYR250
A	ARG262
A	ARG273
A	SER326
A	LYS329
A	HOH506
A	HOH512
A	HOH522
A	HOH557
A	HOH578
A	HOH589
A	HOH665
A	HOH703
A	HOH710
A	HOH743
A	HOH747

---

site_id	AC3
Number of Residues	5
Details	binding site for residue MG A 403

Chain	Residue
A	ASP321
A	ASN323
A	ADP401
A	HOH515
A	HOH705

---

site_id	AC4
Number of Residues	5
Details	binding site for residue MG A 404

Chain	Residue
A	ASP309
A	ASP321
A	ADP401
A	HOH549
A	HOH742

---

site_id	AC5
Number of Residues	6
Details	binding site for residue MG A 405

Chain	Residue
A	SER68
A	PHE70
A	ILE73
A	HOH598
A	HOH653
A	HOH750

---

site_id	AC6
Number of Residues	6
Details	binding site for residue ACT A 406

Chain	Residue
A	VAL121
A	ASP124
A	LEU125
A	ASN126
A	HOH612
A	HOH658

---

site_id	AC7
Number of Residues	7
Details	binding site for residue EDO A 407

Chain	Residue
A	ASN90
A	TRP91
A	PRO92
A	PRO283
A	ILE285
A	HOH554
A	HOH741

---

site_id	AC8
Number of Residues	6
Details	binding site for residue ACT A 408

Chain	Residue
A	SER217
A	ARG218
A	LYS270
A	LYS291
A	LEU292
A	HOH542

---

site_id	AC9
Number of Residues	8
Details	binding site for residue EDO A 409

Chain	Residue
A	LYS248
A	TYR250
A	GLY307
A	PHE308
A	ASP309
A	ASN323
A	SER326
A	HOH522

---

site_id	AD1
Number of Residues	7
Details	binding site for residue EDO A 410

Chain	Residue
A	ARG312
A	ALA313
A	GLY315
A	GLN316
A	SER317
A	HOH518
A	HOH527

---

site_id	AD2
Number of Residues	7
Details	binding site for residue EDO A 411

Chain	Residue
A	LYS333
A	TYR334
A	HOH737
A	GLU89
A	ASN90
A	TYR256
A	HIS258

---

site_id	AD3
Number of Residues	2
Details	binding site for residue ACT A 412

Chain	Residue
A	PHE70
A	HOH656

---

site_id	AD4
Number of Residues	6
Details	binding site for residue EDO A 413

Chain	Residue
A	PHE105
A	PRO106
A	LEU107
A	ASP108
A	HOH501
A	HOH607

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9F","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T7A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T99","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9F","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T9A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9F","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T7A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T7A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T99","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9F","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T54","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T9D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9E","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---