5DG8

CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE ETA INSERTING dAMPNPP ACROSS A DNA TEMPLATE CONTAINING 1,N6-ETHENODEOXYADENOSINE LESION

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003684	molecular_function	damaged DNA binding
A	0006281	biological_process	DNA repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	26
Details	binding site for residue DZ4 A 501

Chain	Residue
A	ASP13
A	ARG55
A	ARG61
A	ASP115
A	LYS231
A	MG502
A	MG503
A	HOH607
A	HOH617
A	HOH638
A	HOH644
A	MET14
A	HOH667
A	HOH731
A	HOH746
A	HOH748
A	HOH769
P	DT8
T	EDA4
A	ASP15
A	CYS16
A	PHE17
A	PHE18
A	ILE48
A	ALA49
A	TYR52

---

site_id	AC2
Number of Residues	4
Details	binding site for residue MG A 502

Chain	Residue
A	ASP13
A	MET14
A	ASP115
A	DZ4501

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site_id	AC3
Number of Residues	6
Details	binding site for residue MG A 503

Chain	Residue
A	ASP13
A	SER113
A	ASP115
A	GLU116
A	DZ4501
P	DT8

---

site_id	AC4
Number of Residues	9
Details	binding site for residue GOL A 504

Chain	Residue
A	ARG24
A	PRO244
A	PHE247
A	SER248
A	GLY276
A	GLU277
A	HOH627
A	HOH671
A	HOH673

---

site_id	AC5
Number of Residues	6
Details	binding site for residue GOL A 505

Chain	Residue
A	SER257
A	LEU262
A	LYS293
A	ASN294
A	TRP297
A	HOH752

---

site_id	AC6
Number of Residues	8
Details	binding site for residue GOL A 506

Chain	Residue
A	THR329
A	LEU331
A	GLN336
A	TRP340
P	DA1
P	DG2
T	DT12
T	HOH112

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27284197","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5KFO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27284197","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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