5DG6
2.35A resolution structure of Norovirus 3CL protease in complex an oxadiazole-based, cell permeable macrocyclic (21-mer) inhibitor
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 201 |
| Chain | Residue |
| A | ARG8 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 202 |
| Chain | Residue |
| A | SER7 |
| A | LYS88 |
| B | CL201 |
| B | HOH319 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for residue V66 A 203 |
| Chain | Residue |
| A | PRO136 |
| A | CYS139 |
| A | HIS157 |
| A | ALA158 |
| A | ALA159 |
| A | ALA160 |
| A | LYS162 |
| A | HIS30 |
| A | GLU54 |
| A | GLN110 |
| A | THR134 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue CL B 201 |
| Chain | Residue |
| A | CL202 |
| A | HOH320 |
| B | TRP6 |
| B | SER7 |
| B | LYS88 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Active site: {"description":"For 3CLpro activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00870","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16641296","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23365454","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
