5DG6

2.35A resolution structure of Norovirus 3CL protease in complex an oxadiazole-based, cell permeable macrocyclic (21-mer) inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0006508	biological_process	proteolysis
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue CL A 201

Chain	Residue
A	ARG8

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site_id	AC2
Number of Residues	4
Details	binding site for residue CL A 202

Chain	Residue
A	SER7
A	LYS88
B	CL201
B	HOH319

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site_id	AC3
Number of Residues	11
Details	binding site for residue V66 A 203

Chain	Residue
A	PRO136
A	CYS139
A	HIS157
A	ALA158
A	ALA159
A	ALA160
A	LYS162
A	HIS30
A	GLU54
A	GLN110
A	THR134

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site_id	AC4
Number of Residues	5
Details	binding site for residue CL B 201

Chain	Residue
A	CL202
A	HOH320
B	TRP6
B	SER7
B	LYS88

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: For 3CLpro activity => ECO:0000255|PROSITE-ProRule:PRU00870, ECO:0000269|PubMed:16641296, ECO:0000269|PubMed:23365454

Chain	Residue	Details
A	HIS30
A	GLU54
A	CYS139
B	HIS30
B	GLU54
B	CYS139

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site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Cleavage; by 3CLpro => ECO:0000305|PubMed:17554035, ECO:0000305|PubMed:20976190

Chain	Residue	Details
A	GLU181
B	GLU181

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