5DG3

Structure of Pseudomonas aeruginosa LpxA in complex with UDP-3-O-(R-3-hydroxydecanoyl)-GlcNAc

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0006629	biological_process	lipid metabolic process
A	0008610	biological_process	lipid biosynthetic process
A	0008780	molecular_function	acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity
A	0009245	biological_process	lipid A biosynthetic process
A	0016020	cellular_component	membrane
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0006629	biological_process	lipid metabolic process
B	0008610	biological_process	lipid biosynthetic process
B	0008780	molecular_function	acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity
B	0009245	biological_process	lipid A biosynthetic process
B	0016020	cellular_component	membrane
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0006629	biological_process	lipid metabolic process
C	0008610	biological_process	lipid biosynthetic process
C	0008780	molecular_function	acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity
C	0009245	biological_process	lipid A biosynthetic process
C	0016020	cellular_component	membrane
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0006629	biological_process	lipid metabolic process
D	0008610	biological_process	lipid biosynthetic process
D	0008780	molecular_function	acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity
D	0009245	biological_process	lipid A biosynthetic process
D	0016020	cellular_component	membrane
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
E	0005737	cellular_component	cytoplasm
E	0006629	biological_process	lipid metabolic process
E	0008610	biological_process	lipid biosynthetic process
E	0008780	molecular_function	acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity
E	0009245	biological_process	lipid A biosynthetic process
E	0016020	cellular_component	membrane
E	0016740	molecular_function	transferase activity
E	0016746	molecular_function	acyltransferase activity
F	0005737	cellular_component	cytoplasm
F	0006629	biological_process	lipid metabolic process
F	0008610	biological_process	lipid biosynthetic process
F	0008780	molecular_function	acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity
F	0009245	biological_process	lipid A biosynthetic process
F	0016020	cellular_component	membrane
F	0016740	molecular_function	transferase activity
F	0016746	molecular_function	acyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	25
Details	binding site for residue U21 B 301

Chain	Residue
A	MET114
A	HOH309
B	ASP70
B	LEU71
B	LYS72
B	HIS118
B	HIS121
B	ALA136
B	ALA138
B	HIS140
B	VAL155
A	VAL132
B	HIS156
B	GLN157
B	TYR158
B	HOH414
B	HOH415
B	HOH428
A	ASN133
A	GLY151
A	PHE166
A	ASN194
A	GLU196
A	GLY197
A	ARG200

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site_id	AC2
Number of Residues	18
Details	binding site for residue U21 C 301

Chain	Residue
B	ASN133
B	ILE148
B	PHE166
B	ASN194
B	GLU196
B	ARG200
C	PRO69
C	ASP70
C	LEU71
C	LYS72
C	HIS118
C	HIS121
C	ALA136
C	ALA138
C	HIS140
C	VAL155
C	GLN157
C	HOH401

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site_id	AC3
Number of Residues	25
Details	binding site for residue U21 D 301

Chain	Residue
D	MET114
D	VAL132
D	ASN133
D	ILE148
D	PHE166
D	ASN194
D	GLU196
D	ARG200
D	ARG201
D	HOH403
D	HOH410
D	HOH411
D	HOH419
D	HOH422
D	HOH433
F	ASP70
F	LEU71
F	LYS72
F	HIS118
F	HIS121
F	ALA136
F	ALA138
F	HIS140
F	GLN157
F	HOH310

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site_id	AC4
Number of Residues	17
Details	binding site for residue U21 E 301

Chain	Residue
E	ASP70
E	LEU71
E	LYS72
E	HIS118
E	HIS121
E	ALA136
E	ALA138
E	HIS140
E	GLN157
E	HOH405
F	MET114
F	ASN133
F	ILE148
F	PHE166
F	ASN194
F	GLU196
F	ARG200

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site_id	AC5
Number of Residues	3
Details	binding site for residue PO4 E 302

Chain	Residue
E	ASN194
E	GLU196
E	ARG200

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Functional Information from PROSITE/UniProt

site_id	PS00101
Number of Residues	29
Details	HEXAPEP_TRANSFERASES Hexapeptide-repeat containing-transferases signature. IDprAiIdpsArLAadVqVGpwSiVgaeV

Chain	Residue	Details
A	ILE4-VAL32

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