5DBY

Crystal Structure of Equine Serum Albumin in Complex with Diclofenac and Naproxen Obtained in Displacement Experiment

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0005504	molecular_function	fatty acid binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0008289	molecular_function	lipid binding
A	0009267	biological_process	cellular response to starvation
A	0015643	molecular_function	toxic substance binding
A	0019825	molecular_function	oxygen binding
A	0030170	molecular_function	pyridoxal phosphate binding
A	0031667	biological_process	response to nutrient levels
A	0032991	cellular_component	protein-containing complex
A	0046872	molecular_function	metal ion binding
A	0051902	biological_process	negative regulation of mitochondrial depolarization
A	0072732	biological_process	cellular response to calcium ion starvation
A	1903981	molecular_function	enterobactin binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue DIF A 601

Chain	Residue
A	ASP401
A	ALA405
A	VAL408
A	LYS540
A	GLU541
A	LYS544
A	ACT613
A	HOH783

---

site_id	AC2
Number of Residues	11
Details	binding site for residue NPS A 602

Chain	Residue
A	ASN390
A	PHE402
A	ARG409
A	TYR410
A	LYS413
A	LEU429
A	SER448
A	LEU452
A	SER488
A	HOH717
A	LEU386

---

site_id	AC3
Number of Residues	3
Details	binding site for residue MLI A 603

Chain	Residue
A	TYR333
A	ARG336
A	HIS337

---

site_id	AC4
Number of Residues	3
Details	binding site for residue MLI A 604

Chain	Residue
A	GLY206
A	GLU207
A	ARG208

---

site_id	AC5
Number of Residues	4
Details	binding site for residue MLI A 605

Chain	Residue
A	LYS412
A	ALA538
A	THR539
A	LYS540

---

site_id	AC6
Number of Residues	5
Details	binding site for residue MLI A 606

Chain	Residue
A	ALA303
A	LEU304
A	ALA305
A	ARG336
A	GLU561

---

site_id	AC7
Number of Residues	6
Details	binding site for residue MLI A 607

Chain	Residue
A	LEU190
A	ALA193
A	THR428
A	HIS451
A	LEU454
A	ALA455

---

site_id	AC8
Number of Residues	8
Details	binding site for residue SIN A 608

Chain	Residue
A	TYR149
A	ARG256
A	SER286
A	ILE289
A	ALA290
A	ACT617
A	HOH712
A	HOH725

---

site_id	AC9
Number of Residues	2
Details	binding site for residue ACT A 610

Chain	Residue
A	LYS499
A	LYS533

---

site_id	AD1
Number of Residues	4
Details	binding site for residue ACT A 611

Chain	Residue
A	LYS350
A	SER479
A	LEU480
A	ALA481

---

site_id	AD2
Number of Residues	3
Details	binding site for residue ACT A 612

Chain	Residue
A	SER65
A	HIS67
A	PRO96

---

site_id	AD3
Number of Residues	3
Details	binding site for residue ACT A 613

Chain	Residue
A	ARG409
A	LYS540
A	DIF601

---

site_id	AD4
Number of Residues	3
Details	binding site for residue FMT A 614

Chain	Residue
A	ARG144
A	HIS145
A	LYS185

---

site_id	AD5
Number of Residues	3
Details	binding site for residue FMT A 615

Chain	Residue
A	LYS198
A	SER201
A	TRP213

---

site_id	AD6
Number of Residues	6
Details	binding site for residue LMR A 616

Chain	Residue
A	LYS194
A	ARG217
A	LYS221
A	GLU291
A	ACT617
A	HOH736

---

site_id	AD7
Number of Residues	5
Details	binding site for residue ACT A 617

Chain	Residue
A	TRP213
A	LEU237
A	SIN608
A	LMR616
A	HOH725

---

Functional Information from PROSITE/UniProt

site_id	PS00212
Number of Residues	25
Details	ALBUMIN_1 Albumin domain signature. YkadfteCCpaDdkagCLipkldaL

Chain	Residue	Details
A	TYR160-LEU184
A	TYR352-PHE376
A	PHE550-LEU574

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	192
Details	Domain: {"description":"Albumin 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00769","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	197
Details	Domain: {"description":"Albumin 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00769","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P02769","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28567254","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IIH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	5
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P02768","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P02768","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"UniProtKB","id":"P02768","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P02770","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P07724","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---