5D8Q

2.20A resolution structure of BfrB (L68A) from Pseudomonas aeruginosa

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004322	molecular_function	ferroxidase activity
A	0005506	molecular_function	iron ion binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006811	biological_process	monoatomic ion transport
A	0006826	biological_process	iron ion transport
A	0006879	biological_process	intracellular iron ion homeostasis
A	0008199	molecular_function	ferric iron binding
A	0016491	molecular_function	oxidoreductase activity
A	0020037	molecular_function	heme binding
A	0046872	molecular_function	metal ion binding
A	0070288	cellular_component	ferritin complex
A	0140315	molecular_function	iron ion sequestering activity
B	0004322	molecular_function	ferroxidase activity
B	0005506	molecular_function	iron ion binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006811	biological_process	monoatomic ion transport
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0008199	molecular_function	ferric iron binding
B	0016491	molecular_function	oxidoreductase activity
B	0020037	molecular_function	heme binding
B	0046872	molecular_function	metal ion binding
B	0070288	cellular_component	ferritin complex
B	0140315	molecular_function	iron ion sequestering activity
C	0004322	molecular_function	ferroxidase activity
C	0005506	molecular_function	iron ion binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006811	biological_process	monoatomic ion transport
C	0006826	biological_process	iron ion transport
C	0006879	biological_process	intracellular iron ion homeostasis
C	0008199	molecular_function	ferric iron binding
C	0016491	molecular_function	oxidoreductase activity
C	0020037	molecular_function	heme binding
C	0046872	molecular_function	metal ion binding
C	0070288	cellular_component	ferritin complex
C	0140315	molecular_function	iron ion sequestering activity
D	0004322	molecular_function	ferroxidase activity
D	0005506	molecular_function	iron ion binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006811	biological_process	monoatomic ion transport
D	0006826	biological_process	iron ion transport
D	0006879	biological_process	intracellular iron ion homeostasis
D	0008199	molecular_function	ferric iron binding
D	0016491	molecular_function	oxidoreductase activity
D	0020037	molecular_function	heme binding
D	0046872	molecular_function	metal ion binding
D	0070288	cellular_component	ferritin complex
D	0140315	molecular_function	iron ion sequestering activity
E	0004322	molecular_function	ferroxidase activity
E	0005506	molecular_function	iron ion binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006811	biological_process	monoatomic ion transport
E	0006826	biological_process	iron ion transport
E	0006879	biological_process	intracellular iron ion homeostasis
E	0008199	molecular_function	ferric iron binding
E	0016491	molecular_function	oxidoreductase activity
E	0020037	molecular_function	heme binding
E	0046872	molecular_function	metal ion binding
E	0070288	cellular_component	ferritin complex
E	0140315	molecular_function	iron ion sequestering activity
F	0004322	molecular_function	ferroxidase activity
F	0005506	molecular_function	iron ion binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006811	biological_process	monoatomic ion transport
F	0006826	biological_process	iron ion transport
F	0006879	biological_process	intracellular iron ion homeostasis
F	0008199	molecular_function	ferric iron binding
F	0016491	molecular_function	oxidoreductase activity
F	0020037	molecular_function	heme binding
F	0046872	molecular_function	metal ion binding
F	0070288	cellular_component	ferritin complex
F	0140315	molecular_function	iron ion sequestering activity
G	0004322	molecular_function	ferroxidase activity
G	0005506	molecular_function	iron ion binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006811	biological_process	monoatomic ion transport
G	0006826	biological_process	iron ion transport
G	0006879	biological_process	intracellular iron ion homeostasis
G	0008199	molecular_function	ferric iron binding
G	0016491	molecular_function	oxidoreductase activity
G	0020037	molecular_function	heme binding
G	0046872	molecular_function	metal ion binding
G	0070288	cellular_component	ferritin complex
G	0140315	molecular_function	iron ion sequestering activity
H	0004322	molecular_function	ferroxidase activity
H	0005506	molecular_function	iron ion binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006811	biological_process	monoatomic ion transport
H	0006826	biological_process	iron ion transport
H	0006879	biological_process	intracellular iron ion homeostasis
H	0008199	molecular_function	ferric iron binding
H	0016491	molecular_function	oxidoreductase activity
H	0020037	molecular_function	heme binding
H	0046872	molecular_function	metal ion binding
H	0070288	cellular_component	ferritin complex
H	0140315	molecular_function	iron ion sequestering activity
I	0004322	molecular_function	ferroxidase activity
I	0005506	molecular_function	iron ion binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006811	biological_process	monoatomic ion transport
I	0006826	biological_process	iron ion transport
I	0006879	biological_process	intracellular iron ion homeostasis
I	0008199	molecular_function	ferric iron binding
I	0016491	molecular_function	oxidoreductase activity
I	0020037	molecular_function	heme binding
I	0046872	molecular_function	metal ion binding
I	0070288	cellular_component	ferritin complex
I	0140315	molecular_function	iron ion sequestering activity
J	0004322	molecular_function	ferroxidase activity
J	0005506	molecular_function	iron ion binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006811	biological_process	monoatomic ion transport
J	0006826	biological_process	iron ion transport
J	0006879	biological_process	intracellular iron ion homeostasis
J	0008199	molecular_function	ferric iron binding
J	0016491	molecular_function	oxidoreductase activity
J	0020037	molecular_function	heme binding
J	0046872	molecular_function	metal ion binding
J	0070288	cellular_component	ferritin complex
J	0140315	molecular_function	iron ion sequestering activity
K	0004322	molecular_function	ferroxidase activity
K	0005506	molecular_function	iron ion binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006811	biological_process	monoatomic ion transport
K	0006826	biological_process	iron ion transport
K	0006879	biological_process	intracellular iron ion homeostasis
K	0008199	molecular_function	ferric iron binding
K	0016491	molecular_function	oxidoreductase activity
K	0020037	molecular_function	heme binding
K	0046872	molecular_function	metal ion binding
K	0070288	cellular_component	ferritin complex
K	0140315	molecular_function	iron ion sequestering activity
L	0004322	molecular_function	ferroxidase activity
L	0005506	molecular_function	iron ion binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006811	biological_process	monoatomic ion transport
L	0006826	biological_process	iron ion transport
L	0006879	biological_process	intracellular iron ion homeostasis
L	0008199	molecular_function	ferric iron binding
L	0016491	molecular_function	oxidoreductase activity
L	0020037	molecular_function	heme binding
L	0046872	molecular_function	metal ion binding
L	0070288	cellular_component	ferritin complex
L	0140315	molecular_function	iron ion sequestering activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue ARS A 201

Chain	Residue
A	ASN148
A	GLN151
D	ASN148
D	GLN151
G	ASN148
G	GLN151
K	ASN148
K	GLN151

---

site_id	AC2
Number of Residues	6
Details	binding site for residue MG A 202

Chain	Residue
B	HOH301
B	HOH305
L	HOH317
L	HOH333
L	HOH354
A	HOH349

---

site_id	AC3
Number of Residues	6
Details	binding site for residue MG A 203

Chain	Residue
A	HOH308
A	HOH314
A	HOH375
F	HOH237
K	HOH311
K	HOH325

---

site_id	AC4
Number of Residues	8
Details	binding site for residue ARS B 201

Chain	Residue
B	ASN148
B	GLN151
F	ASN148
F	GLN151
H	ASN148
H	GLN151
L	ASN148
L	GLN151

---

site_id	AC5
Number of Residues	15
Details	binding site for residue HEM B 202

Chain	Residue
A	LEU19
A	ASN23
A	PHE26
A	TYR45
A	MET52
A	ALA55
A	HOH302
B	LEU19
B	ILE22
B	ASN23
B	PHE26
B	TYR45
B	MET52
B	LYS53
B	HOH310

---

site_id	AC6
Number of Residues	6
Details	binding site for residue MG B 203

Chain	Residue
A	HOH303
A	HOH306
B	HOH323
G	HOH226
G	HOH241
G	HOH281

---

site_id	AC7
Number of Residues	8
Details	binding site for residue ARS C 201

Chain	Residue
C	ASN148
C	GLN151
E	ASN148
E	GLN151
I	ASN148
I	GLN151
J	ASN148
J	GLN151

---

site_id	AC8
Number of Residues	16
Details	binding site for residue HEM C 202

Chain	Residue
C	ILE22
C	ASN23
C	PHE26
C	TYR45
C	ILE49
C	MET52
C	LYS53
C	HOH319
C	HOH331
H	LEU19
H	ILE22
H	ASN23
H	PHE26
H	TYR45
H	MET52
H	LEU71

---

site_id	AC9
Number of Residues	5
Details	binding site for residue MG C 203

Chain	Residue
C	HOH309
C	HOH315
E	HOH303
E	HOH312
G	HOH269

---

site_id	AD1
Number of Residues	7
Details	binding site for residue MG C 204

Chain	Residue
B	HOH321
B	HOH330
B	HOH362
C	HOH340
H	ASP34
H	HOH302
H	HOH305

---

site_id	AD2
Number of Residues	8
Details	binding site for residue MG D 201

Chain	Residue
D	ASP132
D	GLU135
D	HOH302
D	HOH334
E	HOH326
G	HOH203
G	HOH207
G	HOH217

---

site_id	AD3
Number of Residues	15
Details	binding site for residue HEM E 201

Chain	Residue
E	LYS53
E	HOH314
G	ILE22
G	ASN23
G	PHE26
G	TYR45
G	MET52
G	LYS53
G	ILE59
E	LEU19
E	ASN23
E	PHE26
E	TYR45
E	ILE49
E	MET52

---

site_id	AD4
Number of Residues	6
Details	binding site for residue MG H 201

Chain	Residue
C	HOH314
H	HOH303
J	HOH307
J	HOH308
J	HOH317
J	HOH335

---

site_id	AD5
Number of Residues	12
Details	binding site for residue HEM I 201

Chain	Residue
I	LEU19
I	ILE22
I	ASN23
I	PHE26
I	PHE26
I	TYR45
I	TYR45
I	ILE49
I	MET52
I	MET52
I	LYS53
I	HOH310

---

site_id	AD6
Number of Residues	6
Details	binding site for residue MG I 202

Chain	Residue
E	GLU135
E	HOH322
E	HOH338
I	HOH302
I	HOH309
I	HOH313

---

site_id	AD7
Number of Residues	5
Details	binding site for residue MG I 203

Chain	Residue
D	HOH329
I	HOH312
I	HOH314
J	HOH306
J	HOH309

---

site_id	AD8
Number of Residues	15
Details	binding site for residue HEM J 201

Chain	Residue
D	LEU19
D	ILE22
D	ASN23
D	PHE26
D	TYR45
D	ILE49
D	MET52
D	LYS53
J	ASN23
J	PHE26
J	TYR45
J	ILE49
J	MET52
J	LYS53
J	ILE59

---

site_id	AD9
Number of Residues	14
Details	binding site for residue HEM K 201

Chain	Residue
F	ASN23
F	PHE26
F	TYR45
F	ILE49
F	MET52
F	LYS53
F	ILE59
K	ILE22
K	ASN23
K	PHE26
K	TYR45
K	MET52
K	HOH303
K	HOH348

---

site_id	AE1
Number of Residues	7
Details	binding site for residue MG K 202

Chain	Residue
D	HOH304
D	HOH305
D	HOH310
J	HOH326
J	HOH339
K	ASP132
K	HOH302

---

site_id	AE2
Number of Residues	6
Details	binding site for residue MG K 203

Chain	Residue
F	HOH205
F	HOH228
F	HOH242
H	HOH316
H	HOH353
K	HOH320

---

site_id	AE3
Number of Residues	14
Details	binding site for residue HEM L 201

Chain	Residue
L	LEU19
L	ILE22
L	ASN23
L	PHE26
L	PHE26
L	TYR45
L	TYR45
L	ILE49
L	MET52
L	MET52
L	LYS53
L	LYS53
L	HOH322
L	HOH348

---

site_id	AE4
Number of Residues	6
Details	binding site for residue MG L 202

Chain	Residue
F	HOH208
F	HOH227
F	HOH254
L	HOH311
L	HOH312
L	HOH334

---

Functional Information from PROSITE/UniProt

site_id	PS00549
Number of Residues	19
Details	BACTERIOFERRITIN Bacterioferritin signature. MkGdkkVIqhLnkiLgneL

Chain	Residue	Details
A	MET1-LEU19

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1728
Details	Domain: {"description":"Ferritin-like diiron","evidences":[{"source":"PROSITE-ProRule","id":"PRU00085","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	72
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20067302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25640193","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3IS8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TOH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D8P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"20067302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22812654","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25640193","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3IS8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4E6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TOH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D8P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7K5E","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20067302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22812654","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25640193","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3IS7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4E6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TOH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D8P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7K5E","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---