5D7Q
Crystal structure of human Sirt2 in complex with ADPR and CHIC35
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0017136 | molecular_function | histone deacetylase activity, NAD-dependent |
| A | 0051287 | molecular_function | NAD binding |
| A | 0070403 | molecular_function | NAD+ binding |
| B | 0017136 | molecular_function | histone deacetylase activity, NAD-dependent |
| B | 0051287 | molecular_function | NAD binding |
| B | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 401 |
| Chain | Residue |
| A | CYS195 |
| A | CYS200 |
| A | CYS221 |
| A | CYS224 |
| site_id | AC2 |
| Number of Residues | 27 |
| Details | binding site for residue AR6 A 402 |
| Chain | Residue |
| A | PHE96 |
| A | ARG97 |
| A | TYR104 |
| A | GLN167 |
| A | HIS187 |
| A | PHE235 |
| A | GLY261 |
| A | THR262 |
| A | SER263 |
| A | VAL266 |
| A | ASN286 |
| A | LYS287 |
| A | GLU288 |
| A | GLY322 |
| A | GLU323 |
| A | CYS324 |
| A | 4I5403 |
| A | HOH513 |
| A | HOH522 |
| A | HOH526 |
| A | HOH542 |
| A | HOH580 |
| A | GLY84 |
| A | ALA85 |
| A | GLY86 |
| A | THR89 |
| A | ASP95 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for residue 4I5 A 403 |
| Chain | Residue |
| A | ILE93 |
| A | PRO94 |
| A | PHE96 |
| A | GLN167 |
| A | ASN168 |
| A | ILE169 |
| A | ASP170 |
| A | ILE232 |
| A | PHE234 |
| A | AR6402 |
| A | HOH557 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue 4I5 A 404 |
| Chain | Residue |
| A | ILE93 |
| A | PHE119 |
| A | ALA135 |
| A | LEU138 |
| A | TYR139 |
| A | GLY141 |
| A | ASP170 |
| A | PHE190 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 401 |
| Chain | Residue |
| B | CYS195 |
| B | CYS200 |
| B | CYS221 |
| B | CYS224 |
| site_id | AC6 |
| Number of Residues | 25 |
| Details | binding site for residue AR6 B 402 |
| Chain | Residue |
| B | GLY84 |
| B | ALA85 |
| B | GLY86 |
| B | THR89 |
| B | ASP95 |
| B | PHE96 |
| B | ARG97 |
| B | TYR104 |
| B | GLN167 |
| B | HIS187 |
| B | PHE235 |
| B | GLY261 |
| B | THR262 |
| B | SER263 |
| B | VAL266 |
| B | ASN286 |
| B | LYS287 |
| B | GLU288 |
| B | GLY322 |
| B | GLU323 |
| B | CYS324 |
| B | 4I5403 |
| B | HOH502 |
| B | HOH504 |
| B | HOH522 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | binding site for residue 4I5 B 403 |
| Chain | Residue |
| B | ILE93 |
| B | PRO94 |
| B | PHE96 |
| B | PHE119 |
| B | GLN167 |
| B | ASN168 |
| B | ILE169 |
| B | ASP170 |
| B | ILE232 |
| B | AR6402 |
| B | 4I5404 |
| B | HOH529 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue 4I5 B 404 |
| Chain | Residue |
| B | ILE93 |
| B | LEU138 |
| B | TYR139 |
| B | GLY141 |
| B | ASP170 |
| B | PHE190 |
| B | 4I5403 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 562 |
| Details | Domain: {"description":"Deacetylase sirtuin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 26 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25672491","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4RMG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11427894","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23454361","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24389023","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25672491","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25704306","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4R8M","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q5RJQ4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
