5D7N
Crystal structure of human Sirt3 at an improved resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0017136 | molecular_function | histone deacetylase activity, NAD-dependent |
| A | 0051287 | molecular_function | NAD binding |
| A | 0070403 | molecular_function | NAD+ binding |
| B | 0017136 | molecular_function | histone deacetylase activity, NAD-dependent |
| B | 0051287 | molecular_function | NAD binding |
| B | 0070403 | molecular_function | NAD+ binding |
| C | 0017136 | molecular_function | histone deacetylase activity, NAD-dependent |
| C | 0051287 | molecular_function | NAD binding |
| C | 0070403 | molecular_function | NAD+ binding |
| D | 0017136 | molecular_function | histone deacetylase activity, NAD-dependent |
| D | 0051287 | molecular_function | NAD binding |
| D | 0070403 | molecular_function | NAD+ binding |
| E | 0017136 | molecular_function | histone deacetylase activity, NAD-dependent |
| E | 0051287 | molecular_function | NAD binding |
| E | 0070403 | molecular_function | NAD+ binding |
| F | 0017136 | molecular_function | histone deacetylase activity, NAD-dependent |
| F | 0051287 | molecular_function | NAD binding |
| F | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 401 |
| Chain | Residue |
| A | CYS256 |
| A | CYS259 |
| A | CYS280 |
| A | CYS283 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue PEG A 402 |
| Chain | Residue |
| A | VAL292 |
| A | PHE293 |
| A | HOH633 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue PEG A 404 |
| Chain | Residue |
| A | CYS259 |
| A | GLN260 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 405 |
| Chain | Residue |
| A | HOH680 |
| F | GLU375 |
| F | HOH571 |
| F | HOH584 |
| F | HOH628 |
| F | HOH645 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 401 |
| Chain | Residue |
| B | CYS256 |
| B | CYS259 |
| B | CYS280 |
| B | CYS283 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue PEG B 402 |
| Chain | Residue |
| B | HIS248 |
| B | VAL292 |
| B | PHE293 |
| B | PHE294 |
| B | HOH502 |
| B | HOH561 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN C 401 |
| Chain | Residue |
| C | CYS256 |
| C | CYS259 |
| C | CYS280 |
| C | CYS283 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue PEG C 402 |
| Chain | Residue |
| C | PHE180 |
| C | HIS248 |
| C | VAL292 |
| C | HOH650 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 401 |
| Chain | Residue |
| D | CYS256 |
| D | CYS259 |
| D | CYS280 |
| D | CYS283 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue PEG D 402 |
| Chain | Residue |
| D | GLU323 |
| D | GOL404 |
| D | HOH690 |
| F | GLU181 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue 1PE D 403 |
| Chain | Residue |
| D | GLN228 |
| D | HIS248 |
| D | VAL292 |
| D | PHE294 |
| D | GLY295 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL D 404 |
| Chain | Residue |
| D | LEU322 |
| D | GLU323 |
| D | GLU325 |
| D | PEG402 |
| F | TYR175 |
| F | GLU177 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN E 401 |
| Chain | Residue |
| E | CYS256 |
| E | CYS259 |
| E | CYS280 |
| E | CYS283 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue PGE E 402 |
| Chain | Residue |
| E | ARG158 |
| E | PHE180 |
| E | HIS248 |
| E | VAL292 |
| E | PHE294 |
| E | GLY295 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN F 401 |
| Chain | Residue |
| F | CYS256 |
| F | CYS259 |
| F | CYS280 |
| F | CYS283 |
| site_id | AD7 |
| Number of Residues | 10 |
| Details | binding site for residue PG4 F 402 |
| Chain | Residue |
| F | ARG158 |
| F | GLN228 |
| F | HIS248 |
| F | VAL292 |
| F | PHE294 |
| F | HOH502 |
| F | HOH505 |
| F | HOH570 |
| F | HOH617 |
| F | HOH636 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12186850","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16788062","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18794531","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36896611","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 162 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23897466","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19535340","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23897466","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36896611","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37720100","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19535340","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23897466","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36896611","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q8R104","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
